NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
News

Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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Biosensor advances drug discovery

Researchers developed a sensor that helped them identify a psychedelic-related drug with antidepressant-like effects that wasn’t hallucinogenic.

Boosting brain's waste removal system could improve Alzheimer's outcomes

A study in mice showed that antibody therapies targeting amyloid-beta protein were more effective after enhancing the brain's waste drainage system.

The genetic effects of Chernobyl radiation exposure

Studies of people exposed to radiation from the Chernobyl accident and their children further our understanding of the genetic effects of radiation exposure.

Uncovering the origins of brown fat

Researchers identified previously unknown origins of brown fat, which burns energy to create heat for the body.

Oral antiviral drug effective against COVID-19 in hamsters

An oral antiviral drug called MK-4482 inhibited SARS-CoV-2 replication in hamsters. It is currently being tested in people.

Lack of sleep in middle age may increase dementia risk

People who slept six hours or less per night in their 50s and 60s were more likely to develop dementia later in life.

Targeted treatments for small-cell lung cancer

A rapid screening process identified a two-drug combination that shrank small-cell lung tumors, which are often fatal within weeks of recurrence.