NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
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Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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Intranasal COVID-19 vaccine effective in animal studies

A nasal spray of a COVID-19 vaccine protected hamsters and monkeys against serious disease and reduced the amount of virus in the nose.

Detergent-like protein kills bacteria in human cells

Researchers identified a protein that acts like a detergent to kill bacteria that get inside human cells.

Device allows paralyzed man to communicate with words

Researchers developed a device to decode brain activity into words, allowing a person with paralysis to communicate in complete sentences.

High-dose buprenorphine for opioid withdrawal

High-dose buprenorphine treatment of opioid withdrawal in an emergency department appeared safe and provided symptom relief within a few hours.

Gene therapy restores missing enzyme in rare childhood disease

A small study found that gene therapy delivered into the brain was safe and beneficial in treating a debilitating neurological disease.

Immune boost fights antibiotic-resistant infections in mice

In studies in mice, a drug boosted the natural ability of the immune system to fight off antibiotic-resistant bacteria.

Experimental vaccine protects against multiple coronaviruses

By combining parts of spike proteins from different coronaviruses, researchers developed an mRNA vaccine that protected mice against a range of coronaviruses.