NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
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Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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SARS-CoV-2 may infect mouth cells

Researchers found that SARS-CoV-2, the virus that causes COVID-19, can infect cells in the mouth, yielding insights into the mouth’s role in infection

Drug prescriptions in older adults with dementia

An analysis found that almost 14% of older adults with dementia had long-term prescriptions for three or more medications that affect the nervous system.

Gene therapy for chronic pain relief

Turning off a particular gene prevented or alleviated chronic pain in mice. The results could lead to an alternative to opioids for treating chronic pain.

Fungi may impair wound healing in Crohn's disease

A fungus called Debaryomyces hansenii impaired gut wound healing in mice, and was also found in damaged gut tissue in people with Crohn's disease.

Measles vaccine used as base for experimental COVID vaccine

Scientists developed a SARS-CoV-2 vaccine by adding a key coronavirus gene to the measles vaccine.

Mitochondrial DNA involved in sickle cell disease

People with sickle cell disease have high levels of mitochondrial DNA in their blood, which may help trigger damaging inflammation.

Drug delays type 1 diabetes onset

In a clinical trial, the drug teplizumab delayed type 1 diabetes onset and improved insulin production in high-risk individuals.