NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
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Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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Changing long-term opioid prescribing behavior

Notifying clinicians that one of their patients died of an overdose reduced the amount of opioids they prescribed for up to a year afterwards.

Lab-grown eye cells form new neural connections

Eye cells that were grown from skin-derived stem cells could be collected from 3D cultures and coaxed to form new neural connections.

Link between hydration and aging

Higher blood sodium in middle age was associated with increased mortality, chronic disease risk, and biological aging.

Gut microbes may affect motivation to exercise

Researchers found a pathway by which gut microbes affect levels of exercise in mice. The findings, if confirmed in humans, suggest strategies to help encourage people to exercise.

Paxlovid reduces serious risks from Omicron variants

The antiviral treatment Paxlovid reduced the risk of hospitalization or death from SARS-CoV-2 Omicron variants in older adults by 44%.

Blood test for early Alzheimer's detection

Researchers developed a blood test that could detect Alzheimer's disease-promoting compounds in the blood long before symptoms emerged.

2022 Research Highlights - Human Health Advances

NIH accomplishments in disease prevention, diagnosis, and treatment include insights into Covid-19 vaccines, advances for type 1 diabetes, and a robotic exoskeleton that helps people walk.