NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
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Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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Experimental male contraceptive blocks sperm movement

Researchers developed a compound that temporarily interferes with sperm motility in rhesus macaques. The study might point the way toward a reversible male contraceptive.

Gene therapy reduces need for transfusions in severe blood disorder

Gene therapy reduced or eliminated the need for blood transfusions in patients with a severe blood disorder called beta-thalassemia.

Sleep deprivation increases Alzheimer's protein

In a small study, losing just one night of sleep led to an increase in beta-amyloid, a protein in the brain associated with Alzheimer's disease.

Epstein-Barr virus and autoimmune diseases

Researchers found a mechanism that may explain why the Epstein-Barr virus is associated with certain autoimmune illnesses such as lupus.

Study reveals subtypes of lymphoma

Researchers identified genetic subtypes of diffuse large B-cell lymphoma, the most common type of lymphoma, and showed that these subtypes can be used to predict treatment response.

Lingering feelings over daily stresses may impact long-term health

Researchers found that people who continued to have negative feelings about a stressful event the day after were more likely to have health issues ten years later.

Disrupting normal hormone cycle spurs fat cells

In mice, interfering with the natural cycle of a certain hormone spurs development of fat cells. The finding may help explain how stress and conditions that affect hormone levels can cause obesity.