NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
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Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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Medications reduce risk of death after opioid overdose

Drugs for opioid-use disorder reduced the risk of death by about half for people who’d previously had an opioid overdose. But less than a third of participants received these drugs.

Intensive weight loss helps knee arthritis

Intensive weight loss from diet and exercise was better than moderate weight loss for relieving symptoms of knee arthritis among obese or overweight older adults.

Immune-suppressing drugs linked to lower risk of Parkinson's disease

An analysis of prescription data showed that older adults who take certain drugs that suppress the immune system were less likely to develop Parkinson's disease.

Breast cancer patient benefits from modified immunotherapy

Researchers designed a novel approach to immunotherapy that led to the complete regression of breast cancer in one patient for whom all other treatments failed.

Targeting inflammation molecules reduces heart and liver disease in mice

In mouse studies, researchers found mechanisms connecting molecules thought to promote inflammation and the increased risk of diseases caused by a high-cholesterol diet.

Test predicts whether chemotherapy will help early-stage breast cancer patients

Among women with the most common type of breast cancer, those with certain genetic risk scores didn’t benefit from receiving chemotherapy in addition to hormone therapy.

Many with mild traumatic brain injury don't receive follow-up care

A study suggests that people with long-term symptoms from concussions may not be receiving treatments that could improve their physical and mental health.