NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
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Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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2019 Research Highlights - Basic Research Insights

Noteworthy NIH advances in basic research include evidence linking enterovirus infections with acute flaccid myelitis, insights into how disrupted sleep may lead to heart disease, and nanoparticle robots that sweep away biofilms.

Drugs equally effective for severe seizure disorder

Three commonly prescribed anti-seizure drugs worked equally well for seizures in patients with a severe form of epilepsy called refractory status epilepticus who didn’t respond to benzodiazepines.

Newly identified oral stem cell key to wound healing

Researchers found a unique population of stem cells in the roof of the mouth that quickly respond to stress from chewing and injury.

Two drugs reduce risk of death from Ebola

Two experimental drugs each reduced the risk of death from Ebola when tested in an outbreak in the Democratic Republic of Congo.

Some Down syndrome problems reversed in mice

In a mouse model of Down syndrome, blocking a cellular pathway in brain cells improved learning and memory.

Targeting gut bacteria to treat alcoholic hepatitis

A therapy targeting bacteria that make a specific toxin lessened alcohol-associated liver disease in a mouse study.

Some melanomas may start in hair follicles

A rare form of skin cancer may sometimes start with cancer-causing mutations in hair follicle stem cells.