NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
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Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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Weekend catch-up can't counter chronic sleep deprivation

People with consistent sleep deprivation gained weight and experienced a loss of insulin sensitivity. Weekend "recovery" sleep only seemed to make things worse.

"Intelligent" injection device targets tissues

Researchers developed a resistance-sensitive injection device that could help reduce errors when targeting tissues that are difficult to reach using traditional syringes.

Reduced-calorie diet lowers signs of inflammatory bowel disease

Feeding mice cycles of a certain low-calorie diet improved signs of inflammatory bowel disease. Feeding people a similar diet seemed to reduce overall inflammation.

Doubling the building blocks for DNA

Scientists created novel DNA structures from four synthetic and four natural building blocks.

How disrupted sleep may lead to heart disease

Researchers found that sleep disruption activates a molecule that triggers inflammation and leads to fatty buildup in mouse arteries.

Nutrition supplement increases infant birth size

Women in lower-income countries who received nutritional supplements before or early in pregnancy were more likely to give birth to healthy-sized babies.

Understanding recurrent tonsillitis

In children with recurrent tonsillitis, the bacteria that cause the disease trick immune cells into destroying each other instead of remembering the bacteria.