NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
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Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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Robotic screening speeds testing of oral drugs

A robotic system to rapidly test the absorption of drugs in the small intestine could help speed the development and testing of oral medications.

Poor sleep linked with higher blood sugar levels in African Americans

African American men and women who had severe sleep apnea or other disrupted sleep patterns had higher blood sugar levels than those who slept normally.

Infant temperament predicts introversion in adulthood

A study highlighting the enduring nature of early temperament suggests ways to identify those most at risk for developing anxiety and depression later in life.

Blocking enzyme inhibits arthritis progression in mice

Blocking an enzyme called TET1 protected mice against the development of osteoarthritis and cells from people with osteoarthritis from gene changes that help drive the disease.

Lab-made eye cells restore vision in mice

Researchers reprogrammed skin cells into light-sensing eye cells that restored sight in mice. The technique may lead to new approaches for modeling and treating eye diseases.

Dopamine modification on chromatin linked to addiction

Researchers found that dopamine can modify the structure that DNA is packed into and alter gene expression following cocaine exposure.

Drop in coal power plant emissions associated with asthma improvements

Reductions in sulfur dioxide emissions from coal-fired power plants were associated with fewer local hospitalizations and emergency department visits due to asthma.