NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
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Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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Repurposed drug combats obesity in mice

Obese mice lost weight and showed improved metabolic function when treated with a drug that’s normally prescribed for alcohol use disorder.

Llama antibody engineered to block coronavirus

Based on antibodies isolated from llamas, researchers engineered an antibody that prevented SARS-CoV-2, the virus that causes COVID-19, from entering cells in laboratory experiments.

Sex differences in autoimmune disorders and schizophrenia

A new study suggests that an immune-related protein found in higher levels in men helps protect against certain autoimmune diseases but increases the risk of schizophrenia.

How the nose decodes complex odors

Researchers showed how receptors in the nose help decode the smell of complex odor mixtures.

New insight into regenerating prostate tissue

Progress in understanding how the prostate regenerates after hormone therapy may one day lead to improved therapies for prostate cancer.

Alzheimer's gene contributes to blood-brain barrier breakdown

Damage to the blood-brain barrier may contribute to the development of Alzheimer's dementia in people carrying a high-risk gene variation.

New genetic regions linked to risk of melanoma

Researchers linked new regions of the genome to melanoma, the deadliest form of skin cancer, suggesting new avenues to explore for a better understanding of the disease.