NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
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Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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Blood tests show promise for early Alzheimer's diagnosis

Blood levels of a protein called ptau217 were associated with damage to the brain caused by Alzheimer's disease, and may one day help diagnose disease before symptoms appear.

Screening drug additives for biological activity

A computational screen of more than 600 compounds listed as FDA-approved inactive ingredients found some that may warrant follow-up studies for previously unknown effects.

Potent neutralizing antibodies target new regions of coronavirus spike

Researchers identified some of the most potent and diverse antibodies discovered to date that neutralize SARS-CoV-2, targeting multiple regions on the viral spike.

High blood sugar may blunt benefits of aerobic exercise

Mice with high blood sugar levels had lower gains from aerobic exercise than normal mice. The results suggest that diet changes may be needed to get the most from aerobic exercise.

What goosebumps are for

Researchers discovered a new role for goosebumps that could have implications for reversing hair loss and understanding wound healing in the skin.

Approach to prevent fall injuries no better than usual care

In a large study, individualized plans designed to prevent serious injuries from falls among older adults who are at high risk didn’t improve upon usual care.

Sex differences in brain anatomy

An analysis of more than 2,000 brain scans showed sex differences in the volume of certain regions in the human brain that may contribute to differences in brain disease and behavior.