NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
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Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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Aging insights from reptiles and amphibians

Researchers identified patterns in the aging rates and longevity of reptiles and amphibians that suggest how these traits evolved.

Using viruses to treat antibiotic-resistant bacterial infections

In several patients, treatment of bacterial lung infections with viruses called phages eliminated the infection.

Long COVID symptoms linked to inflammation

Prolonged inflammation after SARS-CoV-2 infections caused permanent damage to lungs and kidneys, affected the brain, and correlated with behavioral changes in hamsters, suggesting a mechanism for the symptoms of Long COVID in people.

Brain cells that control sickness symptoms

Researchers identified a group of neurons in mice that trigger sickness symptoms, such as fever and loss of appetite, in response to infections.

Priming the brain to learn

After people were incidentally exposed to new objects, they learned to categorize them faster when explicitly taught to recognize them later.

Improved dietary supplement for age-related macular degeneration

Replacing a component of a dietary supplement for treating age-related macular degeneration improved its safety and efficacy over a 10-year period.

Combination antibody treatment for HIV

A combination of anti-HIV antibodies suppressed the virus for several months without the need for daily antiretroviral therapy.