NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
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Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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Racial segregation makes consequences of lead exposure worse

Racial segregation and lead exposure amplified each other’s detrimental effects on reading scores in children.

Measuring placental health noninvasively

An experimental system used laser light and ultrasound to measure changes in oxygen levels in the placenta.

Children's sleep linked to brain development

Pre-teens who slept less than nine hours daily had differences in brain structure and more problems with mood and thinking compared to those who got sufficient sleep.

Customized drug to kill brain cancer cells

Researchers designed a new type of drug that causes lethal DNA damage in a type of brain cancer called glioblastoma, but not in normal cells.

Antibody treatment protects adults against malaria

A single low dose of an experimental monoclonal antibody safely and effectively prevented malaria infection in a small clinical trial.

Learning to control microglia using CRISPR

Researchers used CRISPR tools to identify genes controlling cells in the brain called microglia, which are involved in Alzheimer’s disease and other brain disorders.

Restoring cell and organ function after the heart stops

Researchers restored cellular function in a pig’s organs more than an hour after its heart stopped.