NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
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Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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Toward a deeper understanding of long COVID

Researchers developed a symptom scoring system to help identify adults who may have long COVID.

Brain activity predicts chronic pain

In a small study of four people, researchers identified brain activity patterns associated with chronic pain.

Quick catnaps may spark creativity

Researchers found evidence that the brief period when drifting off to sleep may be a sweet spot for dreams that facilitate creative thinking and problem solving.

Long telomeres may heighten cancer risks

People with mutations that lead to excessively long chromosome tips, or telomeres, may be at increased risk for a range of cancers.

An mRNA vaccine to treat pancreatic cancer

A personalized mRNA vaccine against pancreatic cancer created a strong anti-tumor immune response in half the participants in a small study.

Human pangenome boosts accuracy and reflects diversity

Researchers compiled a set of reference human genome sequences—a “pangenome”—that represents human genetic diversity better than any single genome.

Earlier smoking cessation may improve lung cancer survival

Lung cancer patients who quit smoking before diagnosis had significantly better survival rates than smokers—and the longer without smoking, the better the odds of survival.