NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
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Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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Understanding "exceptional responders" to cancer treatment

Molecular changes in the tumors of patients who are exceptional responders to cancer treatments may suggest personalized treatment approaches for cancer patients.

Hormone suppresses hunger in primates and people

A hormone called LCN2 suppressed hunger after eating, researchers found, and levels were depressed in people with obesity.

Molecule guides stem cells to damaged brain tissue

Scientists altered a molecule that is naturally produced by the body to safely guide stem cells to damaged brain tissue in mice.

Hydroxychloroquine doesn't benefit hospitalized COVID-19 patients

In a final analysis of study data, researchers concluded that the medication hydroxychloroquine provides no benefit to adults hospitalized with COVID-19.

Life support machine helps cardiac arrest patients survive

Using a life support machine called ECMO shortly after cardiac arrest outside of a hospital improved patients’ chances of survival.

Immune cells trained in the gut protect the brain

Researchers found that the brain’s protective membranes are guarded against microbes by immune cells that are trained in the gut.

Postpartum depression may last for years

About 5% of women reported persistently high levels of postpartum depression symptoms for three years after giving birth.