NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
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Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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Identifying barriers to life-saving diarrhea care

A study in India found that children with diarrhea often aren’t given oral rehydration salts because providers assume that parents prefer other treatments.

SARS-CoV-2 fragments may cause problems after infection

Researchers found that fragments of SARS-CoV-2 left behind after the immune system fights off infection may continue to trigger immune responses.

Gaps allow substances to move in and out of the brain

Gaps around blood vessels that cross the layers of tissues protecting the brain allow certain cells and molecules to move between the brain and the body.

Blood test may predict psychosis risks

Scientists identified molecules in blood that may reflect a person’s risk for severe psychotic symptoms and future hospitalizations, and may point to personalized treatment options.

Understanding sex differences in autoimmune disease

The activity of a type of RNA called Xist may help explain why autoimmune diseases are more common in women than men.

Obesity disrupts mitochondria, reduces fat-burning

Scientists identified a protein that triggers changes in mitochondria that lead to reduced fat-burning to promote weight gain in mice fed a high-fat diet.

How the brain produces speech

Researchers identified how neurons in the human brain encode various elements of speech. The findings might be used to help develop treatments for speech and language disorders.