NIH Research Matters

Middle-aged woman holds the back of her left hand to her forehead.
News

Antiviral drug did not improve Long COVID symptoms

A clinical trial for Long COVID found that treating patients with a common antiviral drug for up to 25 days did not improve symptoms.
X-ray of the human lung.
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tRNA treatment may help restore cystic fibrosis proteins

Lipid nanoparticles delivering engineered transfer RNA restored functional proteins in cell and animal models of cystic fibrosis.
Medical illustration of Clostridioides difficile bacteria
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Bacterial infection may alter developing gut

C. difficile bacteria caused lasting changes to cells in the intestines of newborn mice.

 

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3D human liver reconstruction reveals changes in cirrhosis

A new 3D reconstruction of human liver tissue revealed changes to the liver’s internal structure in liver disease.

Engineered immune cells target Alzheimer’s disease protein

Scientists designed a T cell that reduced signs of disease in the brains of a mouse model for Alzheimer’s disease.

How the environment can shape future allergies

A study in mice sheds light into how early exposure to microbes and allergens might help protect against overactive immune responses.

Bacteria play key role in kidney stones

Scientists discovered that bacteria are a key component of kidney stones, including types of stones previously thought to harbor no bacteria.

How age alters sepsis outcomes

Researchers found a biological pathway that helps young mice survive severe infections but has the opposite effect in older mice.

Progress toward a blood test for early pancreatic cancer

Scientists identified markers in blood that could help identify pancreatic cancer at earlier stages, when it is more treatable.

Manipulating gene activity to reverse aging

By altering levels of molecules called transcription factors in mice, researchers were able to reverse some of the effects of aging.