An official website of the United States government
The NIH BRAIN Initiative U24 funding opportunity provides up to 5 years of support to projects aiming to broadly disseminate developed and validated tools and resources, that are highly relevant to specific goals of the BRAIN Initiative. Below are useful resources for those interested in applying to the U24 program, as well as those interested in using the tools and technologies that are being disseminated by funded U24 projects.
Key Resources
- Milestone Template
- Frequently Asked Questions for U24 Applicants
- U24 Informational Webinar Slides and recording
Current U24 Projects
| Name | Description | Category | Contact/PI |
|---|---|---|---|
| Addgene Antibody Open Resource | Recombinant antibodies for neuroscience research in plasmid/protein format and data about their usage | Neural Histology | Melina Fan |
| Allen Brain Cell (ABC) Atlas | A platform for visualizing and analyzing multimodal single cell and spatial transcriptomics data across the whole mammalian brain in multiple datasets simultaneously | Neuroinformatics | Jeremy Miller |
| BCI2000 | A general-purpose software platform for research and development of adaptive neurotechnologies. | Neurophysiology - Human | Peter Brunner |
| Brain Modeling Tools: BMTK | Comprehensive user support and a dissemination platform for the software tools that facilitate many aspects of modeling in neuroscience, including the Brain Modeling ToolKit (BMTK) software suite for model building/simulation. | Neuroinformatics | Anton Arkhipov |
| Brain Modeling Tools: SONATA | Comprehensive user support and a dissemination platform for the software tools that facilitate many aspects of modeling in neuroscience, including the SONATA file format for efficient storage of model and simulation data. | Neuroinformatics | Anton Arkhipov |
| Brain Modeling Tools: VND | Comprehensive user support and a dissemination platform for the software tools that facilitate many aspects of modeling in neuroscience, including the Visual Neuronal Dynamics (VND), which offers powerful 3D visualization capabilities for neuronal network models. | Neuroinformatics | Anton Arkhipov |
| Cell Type Knowledge Explorer | A web tool for exploration of cell types in primary motor cortex that span data modalities, species, and levels of resolution | Neuroinformatics | Jeremy Miller |
| Center for Advanced Motor Bio-Engineering and Research (CAMBER) | Creation and dissemination of high density electrode arrays ("Myomatrix arrays") for recording muscle activity | Neurophysiology- Nonhuman | CAMBER team |
| Cloud-based resources for optical brain mapping | Cloud-based resources for optical brain mapping that facilitate efficient, accurate, and standardized processing to harmonize measurement and analysis strategies throughout the greater brain mapping community | Neuroimaging | Adam Eggebrecht |
| Connectome 2.0 | A next-generation 3T MRI scanner designed for performing connectomics and imaging of human brain circuits at the mesoscopic and microscopic scales using the latest high-performance gradients and radiofrequency coil technology | Neuroimaging | Connectome 2.0 U24 |
| DataJoint Elements | Standardized workflows for neurophysiology experiments, managing data and automated analyses. | Neuroinformatics | Dimitri Yatsenko |
| FlyWire | Whole-Brain Connectome of an adult female Drosophila featuring AI-segmented, expert-proofread neurons with millions of connections, crowdsourced labels, and neurotransmitters | Connectomics | Mala Murthy |
| fMRI Echo Planar Time-resolved Imaging (EPTI) | A new functional MRI acquisition technology with improved functional sensitivity and specificity | Neuroimaging | Fuyixue Wang |
| Human Neocortical Neurosolver (HNN) | The Human Neocortical Neurosolver (HNN) is an open source software platform for cellular and circuit level investigation of human magneto- and electro-encephalography (MEG/EEG) signals. | Neuroinformatics | Stephanie Jones |
| MapMyCells | A web tool that allows scientists worldwide to assign cell types to their own transcriptomics and spatial data by comparing their data to mouse and human brain atlases derived by the Allen Institute for Brain Science and BICAN | Neuroinformatics | Jeremy Miller |
| MAPseq/BARseq Core Facility | Providing services and consultations on mapping long-range projections of neurons at single-cell resolution by cellular barcoding and sequencing | Circuit Analysis Reagents | Huiqing/Ching Zhan |
| MoSeq | An interactive pipeline and toolkit for unsupervised discovery of repeated motifs in 3D video of freely behaving mice. | Behavioral Neuroscience | Sandeep Robert Datta |
| National Center for Microscopy and Imaging Research (NCMIR) | Provides access and support in the integrative use of advanced, high throughput multiscale imaging technologies, tools and analysis strategies for brain research | Connectomics | Mark Ellisman |
| Neurodata Without Borders (NWB) | Neurodata Without Borders: Neurophysiology (NWB:N) is a data standard for neurophysiology, providing neuroscientists with a common standard to share, archive, use, and build analysis tools for neurophysiology data. | Neuroinformatics | Oliver Ruebel |
| NeuroImaging Chart (NiChart) | NiChart is a framework that integrates modular software tools designed for robust image processing, data analysis, and the development and application of machine learning-based neuroimaging models | Neuroimaging | Guray Erus |
| NeuroJSON | JSON-based open standards and tools to make neuroimaging data human-readable, universally parsable, reusable and discoverable | Neuroinformatics | Qianqian Fang |
| Neuroscience Monoclonal Antibody Sequencing Initiative (NeuroMabSeq) | Renewable recombinant antibodies and affinity reagents for neuroscience research. | Neural Histology | Karl Murray |
| NexGen 7T | A next-generation 7T MRI scanner designed for ultra-high-resolution human brain imaging incorporating the latest advances in gradient coil, RF array coil, parallel transmit and pulse sequence design | Neuroimaging | Alex Beckett |
| Open Ephys GUI | Software for processing, recording, and visualizing multichannel electrophysiology data. | Neurophysiology - Nonhuman | Josh Siegle |
| OpenMind Consortium | Tools and resources to support and strengthen the community of researchers and innovators leading the way in the field of advanced neuromodulation | Neurophysiology - Human | Heather Dawes |
| OpenScope | A community-driven brain observatory for large-scale systems neuroscience. | Neurophysiology - Nonhuman | Jerome Lecoq |
| Polymer Implantable Electrode (PIE) Foundry | A service to expand access to polymer-based microelectrode arrays, by providing user training, quality control testing, and custom-made devices and tools. | Neurophysiology - Nonhuman | Ellis Meng |
| Stanford Program for Integrated Neuroscience Technologies (SPrINT) | Platform for the integration of innovative technologies in animal behavior, disease models, neuroimaging, gene and viral vector technologies and human brain organogenesis to external investigators | Behavioral Neuroscience, Circuit Analysis Reagents | Erwin Defensor |
| Two-photon spectrometer | Resource for multiphoton characterization of genetically-encoded fluorescent probes. | Circuit Analysis Reagents | Mikhail Drobizhev |
| UNC Neuroscience NeuroTools | Custom adeno-associated virus (AAV), rabies (RBV), lenti (LV), and herpes simplex virus (HSV) vectors for the neuroscience community using specialized purification strategies | Circuit Analysis Reagents | Kim Ritola |
| Vendor-agnostic functional and structural MRI sequences for multi-site studies | Provides open-source code for creating and reconstructing MRI sequences using the Pulseq sequence description | Neuroimaging | Jon-Fredrik Nielsen |
| Virtual Observatory of the Cortex (VORTEX) | Shares the MICrONS connectome dataset, an electron microscopy reconstruction of a cubic millimeter of cortex, with the scientific community, and supports further research and refinement within the dataset | Connectomics | Bethanny Danskin |