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An mRNA vaccine to treat pancreatic cancer
A personalized mRNA vaccine against pancreatic cancer created a strong anti-tumor immune response in half the participants in a small study.
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Human pangenome boosts accuracy and reflects diversity
Researchers compiled a set of reference human genome sequences—a “pangenome”—that represents human genetic diversity better than any single genome.
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Long telomeres may heighten cancer risks
People with mutations that lead to excessively long chromosome tips, or telomeres, may be at increased risk for a range of cancers.
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May 10, 2022 Edition
Intranasal proteins could protect against COVID-19 variants
Proteins designed to be resistant to new SARS-CoV-2 variants protected mice against infection when given through the nose.
Study links synthetic chemicals to liver damage
A review of more than one hundred studies found that PFAS, synthetic chemicals found in many common products, are linked to markers of liver damage.
May 3, 2022 Edition
How breathing activates lung defenses against viruses
Researchers used advanced tissue chip technology to learn how the physical forces of breathing help boost immunity in lung tissue.
Blood marker shows potential for tracking frontotemporal dementia
Blood levels of a protein called NfL could help identify people with a brain disease called frontotemporal dementia, or FTD, even in its early stages.
Treatment for macular edema has long-lasting gains
A treatment for macular edema due to retinal vein occlusion yielded vision gains for at least five years, although many patients required ongoing treatment.
April 26, 2022 Edition
Obesity alters response to anti-inflammatory treatment
A treatment for severe skin inflammation that works well in lean mice made the condition worse in obese mice because of immune-cell changes associated with obesity.
E-cigarettes may complicate teen attempts to quit nicotine
Among U.S. teens, unsuccessful attempts to quit smoking rose in 2020 after years of decline—a reversal that might relate to the recent rise in vaping.
Viruses in the gut influence inflammatory bowel disease
Viruses isolated from people with inflammatory bowel disease, or IBD, triggered inflammation in human cells and mice, while those from non-diseased guts didn’t.
April 12, 2022 Edition
Understanding how the brain tracks social status and competition
In mouse studies, researchers gained insight into how different brain areas help process information related to social status, competition, and other group dynamics.
First complete sequence of a human genome
Researchers finished sequencing the roughly 3 billion bases (or “letters”) of DNA that make up a human genome.
Nasal antiviral blocks SARS-CoV-2 infection in mice
A compound delivered into the nose blocked a protein used by SARS-CoV-2 to get into cells and prevented severe infection in mice.
April 5, 2022 Edition
System reveals 3D details of living tissues
Researchers developed a system that allows for real-time 3D imaging of living tissues without the need for any dyes.
Compound blocks excess mucus secretion in mouse lungs
In mice, a compound called SP9 blocked the excess secretion of mucus, a feature of many lung diseases that can cause difficulty breathing and other symptoms.
Antibodies recognize new SARS-CoV-2 Omicron variant after booster
After a booster vaccination, levels of antibodies in the blood that could bind to and neutralize a new Omicron subvariant increased substantially.
March 22, 2022 Edition
Mandatory masking in schools reduced COVID-19 cases
Schools with mandatory masking during the Delta surge had less in-school transmission of SARS-CoV-2 than schools with optional or partial masking policies.
Blocking hormone improves Alzheimer's symptoms in mice
Researchers found that a hormone called FSH can act on neurons in the brain and increase the production of proteins implicated in Alzheimer's disease.
Medication helps protect insulin production in type 1 diabetes
A drug approved to treat high blood pressure, called verapamil, protected insulin-producing cells in the pancreas in people with type 1 diabetes.
March 15, 2022 Edition
Imaging technique shows Alzheimer's impact on brain connections
A new imaging technique found that fewer connections between brain cells were associated with the cognitive decline seen in people with early-stage Alzheimer's disease.
How proteins connect common neurodegenerative diseases
Scientists discovered how a mislocated protein implicated in several neurodegenerative diseases affects another protein that’s needed for normal nerve cell functioning.
Vaping alters mouth microbes
People who used electronic cigarettes had unique microbial communities in their mouths that more closely resembled those of smokers than of nonsmokers.
March 8, 2022 Edition
How skin cells help fight acne
A type of skin cell called a dermal fibroblast can make an antimicrobial compound called cathelicidin in response to infection by acne-causing bacteria.
Getting sufficient sleep reduces calorie intake
In a randomized clinical trial, overweight adults who increased how much they slept took in fewer calories.
COVID-19 immune response improves for months after vaccination
Researchers showed that B cells evolve after COVID-19 vaccination to help improve protection against SARS-CoV-2 over time.
March 1, 2022 Edition
Compound produced by bacteria protects the skin
Researchers discovered how a bacterium that lives on the skin, called S. epidermidis, helps protect the skin from water loss and damage.
Calorie restriction, immune function, and health span
A study of moderate calorie restriction in people led to the identification of a gene that is involved in improved immune and metabolic functions.
Use of melatonin supplements rising among adults
The use of melatonin supplements by adults in the United States more than quintupled between 1999 and 2018.