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Previous Directors
| Name | In Office from | To |
|---|---|---|
| Milo D. Leavitt, Jr. | June 16, 1968 | July 1978 |
| Leon Jacobs | July 1, 1978 | June 29, 1979 |
| Edwin D. Becker (Acting) | July 1979 | April 1980 |
| Vida H. Beaven (Acting) | April 1980 | January 1981 |
| Claude Lenfant | February 1981 | July 1982 |
| Mark S. Beaubien (Acting) | July 1, 1982 | January 1984 |
| Craig K. Wallace | January 1984 | December 1987 |
| Carl Kupfer (Acting) | January 1, 1988 | July 1988 |
| Philip E. Schambra | August 1988 | September 30, 1998 |
| Gerald T. Keusch | October 1, 1998 | December 31, 2003 |
| Sharon H. Hrynkow (Acting) | January 1, 2004 | May 2006 |
| Roger I. Glass, M.D., Ph.D. | June 11, 2006 | January 14, 2023 |
| Peter Kilmarx, M.D. (Acting) | January 15, 2023 | May 4, 2024 |
| Kathleen M. Neuzil, M.D. | May 5, 2024 | April 11, 2025 |
| Peter Kilmarx, M.D. (Acting) | April 11, 2025 | June 3, 2026 |