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The NIH HEAL Initiative invests in research to accelerate scientific solutions to address the national opioid overdose crisis and improve pain management. Below, you can explore open Funding Opportunities and Forecasts that support innovative research across the HEAL portfolio.
| Opportunity or Forecast ID | Title | Activity Code | Research Area | Closing Date |
|---|---|---|---|---|
| RFA-AR-27-002 | HEAL INITIATIVE: INTERACT Data Coordination and Integration Center (U24 Clinical Trial Not Allowed) | U24 | Data Dissemination & Secondary Analysis | 10/2/2026 |
| RFA-AT-25-003 | HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional) | R15 | Preclinical | 11/23/2026 |
| RFA-NS-25-023 | HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed) | R61/R33 | Preclinical | 1/15/2027 |
| PA-24-185 | Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed) | K23 | Workforce Development | 5/7/2027 |
| PA-24-194 | NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed) | K99/R00 | Workforce Development | 5/7/2027 |
| PA-24-176 | Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed) | K01 | Workforce Development | 5/7/2027 |
| PA-24-181 | Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Required) | K08 | Workforce Development | 5/8/2027 |
| PA-24-182 | Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed) | K08 | Workforce Development | 5/8/2027 |
| PA-24-183 | Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Basic Experimental Studies with Humans Required) | K08 | Workforce Development | 5/8/2027 |
| PAR-25-100 | Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional) | R34 | Implementation & Health Services, Recovery Services | 5/8/2027 |
| PAS-25-236 | D-START: Data Science Track Award for Research Transition (D/START) (R03-Clinical Trial Optional) | R03 | Data Dissemination & Secondary Analysis | 9/7/2027 |
| RFA-DA-26-055 | Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed) | R01 | Data Dissemination & Secondary Analysis | 12/3/2027 |
| RFA-DA-26-056 | Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed) | R21 | Data Dissemination & Secondary Analysis | 12/3/2027 |
| PA-25-302 | NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed) | R03 | Preclinical, Therapeutics Development, Prevention, Recovery Services, Implementation & Health Services, Life Course & Population, Data Dissemination & Secondary Analysis | 1/7/2028 |
| PA-25-304 | NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed) | R21 | Preclinical, Therapeutics Development, Prevention, Recovery Services, Implementation & Health Services, Life Course & Population, Data Dissemination & Secondary Analysis | 1/7/2028 |
| PA-25-301 | NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) | R01 | Preclinical, Therapeutics Development, Prevention, Recovery Services, Implementation & Health Services, Life Course & Population, Data Dissemination & Secondary Analysis | 1/7/2028 |
| PAR-25-446 | Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional) | UG3/UH3 | Therapeutics Development | 8/21/2028 |
| PA-26-001 | Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) | UG3/UH3 | Preclinical, Therapeutics Development, Prevention, Recovery Services, Implementation & Health Services, Life Course & Population, Data Dissemination & Secondary Analysis | 11/30/2028 |
| RFA-DA-27-016 | HEAL Initiative: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional) | R61/R33 | Prevention, Recovery Services, Implementation & Health Services | 2/9/2029 |
| RFA-NS-27-007 | HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional) | UG3/UH3 | Therapeutics Development | 2/21/2029 |
| RFA-NS-27-007 | HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional) | UG3/UH3 | Therapeutics Development | 02/21/2029 |
| PAR-27-065 | NINDS Efficacy and Exploratory Clinical Trials (UG3/UH3 - Clinical Trial Required) | UG3/UH3 | Therapeutics Development, Prevention, Implementation & Health Services | 03/09/2029 |
| RFA-NS-25-031 | HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) | UG3/UH3 | Therapeutics Development, Implementation & Health Services | FORECASTED |
| RFA-TR-26-002 | Limited Competition: HEAL Initiative Resource Centers for the Pain Management Effectiveness Network (ERN) (Clinical Trial Not Allowed) | ERN | Therapeutics Development, Implementation & Health Services | FORECASTED |
| FOR-DA-27-001 | HEAL Initiative: Integrative Management of Chronic Pain and Opioid Use Disorder (OUD) for Whole Recovery: Health Systems | IMPOWR | Implementation & Health Services | FORECASTED |
| RFA-DA-27-006 | HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center | IMPOWR/BEACON | Implementation & Health Services | FORECASTED |
| RFA-AR-26-006 | Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0 | RE-JOIN | Preclinical | FORECASTED |
| RFA-NS-26-013 | HEAL Initiative: Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins and the Nature of (PRECISION) Human Pain Network | PRECISION | Preclinical | FORECASTED |
| PAR-26-124 | HEAL Initiative Whole Joint Health Program | Whole Joint Health | Preclinical | FORECASTED |
HEAL Highlighted Topics
Each topic represents a selected research priority area within one or more NIH Institutes, Centers, or Offices (ICOs) that may or may not have dedicated funding. See Highlighted Topics for more information.
| Topic | Participating ICOs | Expiration Date |
|---|---|---|
| Novel Targets, Methods, and Pharmacological Approaches to Treat Substance Use Disorder | NIDA, NIAAA, ORWH | 1/28/2027 |
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