Nutrition for Precision Health, powered by the All of Us Research Program | The Common Fund

Program Snapshot

The goal of the NIH Common Fund’s Nutrition for Precision Health, powered by the All of Us Research Program, is to develop algorithms that predict individual responses to food and dietary patterns. Nutrition plays an integral role in human development and in the prevention and treatment of disease. However, there's no such thing as a perfect, one-size-fits-all diet. The NPH program will build on recent advances in biomedical science including artificial intelligence (AI), microbiome research, as well as the infrastructure and large, diverse participant group of the All of Us Research Program. These advances provide unprecedented opportunities to generate new data to provide insight into personalized nutrition also referred to as precision nutrition.

In addition, the first ever Strategic Plan for NIH Nutrition Research emphasized opportunities to improve our understanding of how individual human biology and molecular pathways influence relationships among diet and environmental, social, and behavioral factors to influence health. Designed to implement aspects of the Strategic Plan, the Nutrition for Precision Health program will conduct a study nested in the All of Us Research Program to explore how individuals respond to different diets. The NPH study is the first ancillary study to leverage the All of Us infrastructure to answer scientific questions important to participants like understanding more about the role of nutrition in health. High-quality nutrition studies such as the NPH study will help individuals and their health care providers create healthy, precise, and effective diet plans.

The objectives of the study are:

  1. To examine individual differences observed in response to different diets by studying the interactions between diet, genes, proteins, microbiome, metabolism and other individual contextual factors
  2. To use artificial intelligence (AI) to develop algorithms to predict individual responses to foods and dietary patterns

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The Nutrition for Precision Health program includes several integrated components:

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Nutrition for Precision Health, powered by the All of Us Research Program is a service mark of the U.S. Department of Health and Human Services (HHS).

NPH Center and Site Locations

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Program Background

On September 11, 2020 the NIH Council of Councils approved the concept for a new NIH Common Fund program “Nutrition for Precision Health, powered by the All of Us Research Program.” This program will be refined by NIH for potential implementation in Fiscal Year 2022. The archived videocast of the Council of Councils meeting is publicly available and can be viewed here (Nutrition for Precision Health discussion begins at 1:54:00). Slides and a brief write-up are also available. 

Funded Research 

RFA-RM-21-001

PI NameInstitution NameTitle
LEE, BRUCE Y (contact)
THOMAS, DIANA MARIA		CUNY GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICYArtificial Intelligence, Modeling, and Informatics for Nutrition Guidance and Systems (AIMINGS) Center
Thomas, DianaUnited States Military Academy West PointAI Data Engineering and ML (AIDE-ML) Center

RFA-RM-21-002

PI NameInstitution NameTitle
SUMNER, SUSAN JUNIV OF NORTH CAROLINA CHAPEL HILLMetabolomics and Clinical Assays Center

RFA-RM-21-003

PI NameInstitution NameTitle
GILBERT, JACK ANTHONY (contact)
KNIGHT, ROB		UNIVERSITY OF CALIFORNIA, SAN DIEGOThe UCSD Microbiome and Metagenomics Center

RFA-RM-21-004

PI NameInstitution NameTitle
BOUSHEY, CAROL JUNIVERSITY OF HAWAII AT MANOATraditional and New Dietary Assessment Methods (TANDAM) for Personalized Nutrition

RFA-RM-21-005

PI NameInstitution NameTitle
BOROWSKY, ALEXANDER D (contact)
ADAMS, SEAN HARRISON
ANDERSON, CHERYL ANN MARIE
ANTON-CULVER, HODA A
BENNETT, BRIAN JOSEPH
GOODMAN, MARC T
HIATT, ROBERT A
KIM, KATHERINE K
LI, ZHAOPING
MEEKER, DANIELLA
STEINBERG, FRANCENE M		UNIVERSITY OF CALIFORNIA AT DAVISCalifornia Partnership for Personalized Nutrition
DAS, SAI KRUPA (contact)
KHALILI, HAMED		TUFTS UNIVERSITY BOSTONClinical Center for NIH's Nutrition for Precision Health: The All Of Us New England Research Collaborative
HILL, JAMES O (contact)
GOWER, BARBARA A		UNIVERSITY OF ALABAMA AT BIRMINGHAMUAB Precision Nutrition Clinical Center
MAYER-DAVIS, ELIZABETH JUNIV OF NORTH CAROLINA CHAPEL HILLNutrition for Precision Health: The University of North Carolina at Chapel Hill Clinical Center
RAVUSSIN, ERIC (contact)
BOGARDUS, CLIFTON
REDMAN, LEANNE MAREE		LSU PENNINGTON BIOMEDICAL RESEARCH CTRLAAZ-NPH Clinical Center
VAN HORN, LINDA VERNER (contact)
ASCHEBROOK-KILFOY, BRISEIS A
BURTON-FREEMAN, BRITT
CORNELIS, MARILYN C
HO, JOYCE		NORTHWESTERN UNIVERSITY AT CHICAGONutrition Precision Health for All of Us (Chicago Center)

RFA-RM-21-006

PI NameInstitution NameTitle
GANTZ, MARIE G (contact)
MEHTA, SAURABH		RESEARCH TRIANGLE INSTITUTENutrition for Precision Health, powered by the All of Us Research Program: Research Coordinating Center

PI NameInstitution NameTitle
HARRIS, PAULVANDERBILT UNIVERSITY MEDICAL CENTEREnhancing All of Us Data Resources for Nutrition Precision Health: the All of Us Data and Research Center
THIBODEAU, STEPHEN NORMANMAYO CLINIC ROCHESTERPrecision Medicine Initiative Cohort Program Biobank
JAIN, PRADUMANVIBRENT HEALTHParticipant Technology Systems Center

Related Links & FAQs

Nutrition for Precision Health Frequently Asked Questions