NIH Director's Early Independence Award | The Common Fund

Program Snapshot

Part of the High-Risk, High-Reward Research program, the award supports promising, newly graduated scientists with the intellect, scientific creativity, drive, and maturity to bypass the traditional postdoctoral training period to launch independent research careers.

Single PI only
Recipient of terminal research degree or completed postgraduate clinical training within previous 16 months or expectation to do so within following 12 months of application submission date
Must be in non-independent research position at time of application submission
Limit of 2 applications per institution
Preliminary data not required
Requires 9.6 months of research effort each year for first 2 years
Requires 3-5 Letters of Reference
$350,000 direct costs per year for up to 5 years

View Current Funding Opportunities

Join our Listserv or contact us at EarlyIndependence@od.nih.gov .

Award Overview

The NIH Director’s Early Independence Award (DP5 mechanism), established in 2011, accelerates the entry of exceptional junior investigators (within 16 months after or 12 months before receiving their terminal research degree or completing postgraduate clinical training) into positions of independent research by omitting the traditional postdoctoral training period. The review places a strong emphasis on the qualities of the investigator and the environment provided by the host institution.

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Funded Research

RFA-RM-24-005

PI Name	Institution Name	Title
BOND, JULIA CRAIG	BOSTON UNIVERSITY MEDICAL CAMPUS	Female Sexual Dysfunction and Distress in the Preconception and Perinatal Period
DELROSSO, NICOLE	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Novel high-throughput approaches to discover and dissect human transcriptional protein interactions
GUO, LUCIE YUEQI	STANFORD UNIVERSITY	Building precision disease-responsive gene therapy
JIA, BILL Z	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Decoding the beat: physiological control mechanisms for robust heart development
JONES, GRANT	MASSACHUSETTS GENERAL HOSPITAL	Examining the effects of naturalistic hallucinogen use on internalizing symptoms in a longitudinal sample of young adults
KHAN, YOUSUF A	STANFORD UNIVERSITY	Deciphering the principles and mechanism of RNA structure
KOLAR, MATTHEW JOHN	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Chemoproteomics and Lipidomics for Identifying Dysregulated Enzymes and Lipids in Cutaneous Disorders
PRESSELLER, EMILY KELLEY	DREXEL UNIVERSITY	Rapid innovation of precision psychiatry interventions using dynamic systems modeling and ecological quasi-experiments
SHI, DIANA	MASSACHUSETTS GENERAL HOSPITAL	Molecular Mechanisms of Mutant IDH inhibition and DNA Damage in IDH-mutant Glioma
SORRELLS, JANET	WASHINGTON UNIVERSITY	Illuminating the spatial and temporal diversity of the gastrointestinal microbial ecosystem with label-free nonlinear optical microscopy
TRAXLER, ELIZABETH	UNIVERSITY OF PENNSYLVANIA	Decoding lineage-specific gene regulation across hematopoiesis
WANG, LEO LE	UNIVERSITY OF PENNSYLVANIA	Multicomponent hydrogels activating wound-induced hair neogenesis for scarless wound healing
YOUNG, ANDREW LEE	WASHINGTON UNIVERSITY	Understanding the Impact of Clonal Hematopoiesis on Aging Human Bone Marrow

RFA-RM-23-007

PI Name	Institution Name	Title
BERRY, KAITLYN M	UNIVERSITY OF MINNESOTA	Place-Based Influences on Mortality among People Experiencing Homelessness
CAMACHO, MARIA CATALINA	WASHINGTON UNIVERSITY	A computational model for how risk for anxiety and depression influences affective neurodevelopment
CRAFT, ALEXANDREA L	WOMEN AND INFANTS HOSPITAL-RHODE ISLAND	Juggling Roles: A Study of Diverse Neonatal Intensive Care Unit Parents and Their Work-Family Transition
KEN, MEGAN L	SCRIPPS RESEARCH INSTITUTE, THE	Predictive modeling of viral RNA cellular behavior
MINOR, KELTON	COLUMBIA UNIVERSITY HEALTH SCIENCES	The Behavioral Cost of Carbon
MURPHY, SEDONA	YALE UNIVERSITY	Spatial Regulation of Epigenetic Memory
RAGURAM, ADITYA	WHITEHEAD INSTITUTE FOR BIOMEDICAL RES	Leveraging cell-derived bioparticles for macromolecular delivery
RECH, ANDREW JOHN	UNIVERSITY OF PENNSYLVANIA	Response and resistance to chimeric antigen receptor T cell therapy in human solid tumors using spatial multi-omics
RHOADS, SHAWN A	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	A hierarchical examination of the neural and computational mechanisms underlying loneliness
RODRIGUEZ, VIOLETA DE JESUS	UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN	Optimizing the Assessment of Parenting: A Multi-Method and Multi-Informant Approach
SKINNIDER, MICHAEL ALEXANDER	PRINCETON UNIVERSITY	A machine-learning platform to illuminate the chemical dark matter in mass spectrometry-based metabolomics
ZAVATONE-VETH, JACOB ANDREAS	HARVARD UNIVERSITY	Understanding data-driven models for neural dynamics

RFA-RM-22-021

PI Name	Institution Name	Title
BENNETT, MARIKO L	CHILDREN'S HOSP OF PHILADELPHIA	Unlocking microglia targeting for neurotherapeutics
BERSHAD, ANYA K	UNIVERSITY OF CALIFORNIA LOS ANGELES	MDMA as a Treatment for Social Deficits in Schizophrenia
DHINDSA, RYAN	BAYLOR COLLEGE OF MEDICINE	Identifying transcriptomic and epigenomic convergence in intellectual and developmental disorders
FERENCZI, EMILY ANNE	MASSACHUSETTS GENERAL HOSPITAL	Deciphering Neuronal Control of Behavioral Initiation and Suppression
GBADAMOSI, MOHAMMED OLUSOJI	UNIVERSITY OF FLORIDA	Decoding the Heterogeneity in Chemo-Immunomodulation to Unlock the Potential of Chemoimmunotherapy in Metastatic Triple-Negative Breast Cancer
GUEBLE, SUSAN E	YALE UNIVERSITY	Therapeutic Potential of a Novel MGMT-Dependent DNA Interstrand Crosslinking Agent in the Treatment of DNA Repair Deficient Cancer
KINNEBREW, MAIA	STANFORD UNIVERSITY	Deciphering the lipid composition of primary cilia in human metabolic disease
PINGLAY, SUDARSHAN	UNIVERSITY OF WASHINGTON	Dissecting the logic of mammalian gene regulation using synthetic biology and single-cell sequencing
SEESE, RONALD ROBERT	NORTHEAST OHIO MEDICAL UNIVERSITY	Defining the Autonomic Cerebellum in Autism
SHANMUGAN, SHEILA	UNIVERSITY OF PENNSYLVANIA	Using person-specific networks to uncover sex differences in vulnerability to internalizing disorders
SUSA, KATHERINE JULIA	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Identifying, Characterizing, and Targeting Regulators of B Cell Activation
THEODORIS, CHRISTINA VICKY	J. DAVID GLADSTONE INSTITUTES	Transfer learning leveraging large-scale transcriptomics to map disrupted gene networks in cardiovascular disease
TSAI, JONATHAN MICHAEL	BRIGHAM AND WOMEN'S HOSPITAL	Characterizing a Common Degradation Pathway for Nuclear Hormone Receptors

RFA-RM-21-018

PI Name	Institution Name	Title
AMOR VEGAS, CORINA	COLD SPRING HARBOR LABORATORY	Deconstructing Aging with Senolytic CAR T Cells
BEEL, ANDREW J	STANFORD UNIVERSITY	Structure and Pharmacologic Modulation of the Mitotic Chromosomes Central Axis
GITLIN, ALEXANDER	SLOAN-KETTERING INST CAN RESEARCH	Regulation of Proinflammatory Cytokine Responses by a Caspase-8-N4BP1 Axis
GRAJALES-REYES, GARY E	WASHINGTON UNIVERSITY SAINT LOUIS	CAR-Based Approaches for the Treatment of Alzheimers Disease
HIURA, LISA	UNIVERSITY OF COLORADO	Functional Ontogeny of Pair Bonding Neural Circuits
HOFFMANN, MAGNUS ADRIAN GERO	CALIFORNIA INSTITUTE OF TECHNOLOGY	Self-Assembling Spike-EBR Nanoparticles as a Vaccine Platform Technology Against SARS-CoV-2 and Future Pandemic Coronaviruses.
LI, YUN ROSE	BECKMAN RESEARCH INSTITUTE/CITY OF HOPE	Biomarkers, Mechanisms and Modulation of Oxidative Stress Associated Risk Factors in Carcinogenesis
MILLER, DANNY ERWIN	UNIVERSITY OF WASHINGTON	Long-Read DNA and RNA Sequencing to Identify Disease-Causing Genetic Variation and Streamline Testing
OCANAS, SARAH RENEE	OKLAHOMA MEDICAL RESEARCH FOUNDATION	Sex Chromosomal Regulation of Hippocampal Microglial Activation with Alzheimers Disease and Aging
PINNEY, MARGAUX	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Leveraging Adaptive Evolution and High-Throughput Techniques to Dissect the Link Between Biochemical Function and Fitness
TERKER, ANDREW S	VANDERBILT UNIVERSITY MEDICAL CENTER	Innovative Therapeutic Approaches to Treat Chronic Kidney Disease
WILLIS, MARY D	BOSTON UNIVERSITY MEDICAL CAMPUS	A Preconception Cohort Study on Oil and Gas Development, Fertility, and Pregnancy
XIA, BO	BROAD INSTITUTE, INC.	Transposable Element Interaction and Its Impact on Human Development and Health
YANG, ANDREW CHRIS	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Molecular Tools to Decipher Communication Across the Blood-Brain Barrier

RFA-RM-20-014

PI Name	Institution Name	Title
ABOUD, KATHERINE	VANDERBILT UNIVERSITY	Bridging the Gap Between Brain Network Science and High-Definition Non-Invasive Brain Stimulation to Develop a Scalable Adult Literacy Intervention
AHMED, JALAL	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	Advancing CAR T Cell Therapy for Solid Tumors
BINTU, BOGDAN	UNIVERSITY OF CALIFORNIA, SAN DIEGO	High-Throughput Imaging of 3D Chromatin Regulation Events in the Nervous System
CAPIN, JACOB J	MARQUETTE UNIVERSITY	Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health
KOSS, BRIAN	UNIV OF ARKANSAS FOR MED SCIS	Discovering T Cell Proteome Turnover Dynamics to Overcome the Solid Tumor Microenvironment
LEE, HONG HSI	MASSACHUSETTS GENERAL HOSPITAL	Revealing Tissue Microstructure in the Brain Gray Matter in Alzheimers Disease Using In Vivo High-Gradient Diffusion MRI
MARSHALL, DEBORAH CATHERINE	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	Novel Functional Anatomic and Biomarker Indices of Radiation-Induced Female Sexual Toxicities in a Multi-Center Cohort
NIGRA, ANNE E	COLUMBIA UNIVERSITY HEALTH SCIENCES	Public Drinking Water Contaminants and Infant Health: Advancing Environmental Justice
PITTER, KENNETH L	OHIO STATE UNIVERSITY	Cellular Phenotypic Heterogeneity and Resistance to Radiotherapy in Pancreatic Adenocarcinoma
SHEYBANI, NATASHA DIBA	UNIVERSITY OF VIRGINIA	Immunoengineering Next-Generation Cancer Therapies with Focused Ultrasound
SHMUYLOVICH, LEONID	WASHINGTON UNIVERSITY	Infrared Skin Imaging to Transform Noninvasive Diagnosis and Management of Skin Disease
SIMONETTI, FRANCESCO ROBERTO	JOHNS HOPKINS UNIVERSITY	Investigating Antigen-Driven Clonal Proliferation to Target HIV-1 Persistence
WINETRAUB, YONATAN	STANFORD UNIVERSITY	OCT as a Platform for Non-Invasive Virtual H&E Biopsy

RFA-RM-19-008

PI Name	Institution Name	Title
BAILEY, ADAM LEE	UNIVERSITY OF UTAH	Determinants of Yellow Fever Pathogenesis in Humans
BAXTER, SALLY LIU	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Multi-Modal Health Information Technology Innovations for Precision Management of Glaucoma
BICK, ALEXANDER	VANDERBILT UNIVERSITY MEDICAL CENTER	Targeting Clonal Hematopoiesis of Indeterminate Potential Using Human Genetics
CHO, HYUNGHOON	BROAD INSTITUTE, INC.	Computational Methods for Enhancing Privacy in Biomedical Data Sharing
EXPOSITO-ALONSO, MOISES	CARNEGIE INSTITUTION OF WASHINGTON, D.C.	Predicting and Controlling Polygenic Health Traits Using Probabilistic Models and Evolution-Inspired Gene Editing
GEORGE, JACOB ANTHONY	UNIVERSITY OF UTAH	Patient-Centered Rehabilitation and Dexterous Assistive Devices for Stroke Patients Using Bionic Exoskeletons Controlled by Non-Invasive Eectromyography
HILL, SARAH JAMES	DANA-FARBER CANCER INST	Dissecting the Interaction Between DNA Damage Repair Defects and the Tumor Microenvironment
HO, CHI-MIN	COLUMBIA UNIVERSITY HEALTH SCIENCES	Molecular Basis of Effector Protein Export in the Malaria Parasite Plasmodium falciparum
NAM, SEUNG	WEILL MEDICAL COLL OF CORNELL UNIV	Defining Malignant Hematopoiesis Via Single-Cell Multi-Omics
OPARA, IJEOMA	STATE UNIVERSITY NEW YORK STONY BROOK	Understanding the Role of Neighborhoods on Urban Youths Substance Use and Mental Health: A Community-Based Substance Abuse Prevention Project
STERGACHIS, ANDREW	UNIVERSITY OF WASHINGTON	Investigating the Contribution of Non-Coding Genetic Variation to Rare Disorders
SUEZ, JOTHAM	JOHNS HOPKINS UNIVERSITY	The Role of Non-Nutritive Sweeteners-Microbiome Interactions in the Pathogenesis of Metabolic Syndrome
TRIBLE, WARING	HARVARD UNIVERSITY	The Molecular Basis of Caste Development and Evolution in Ants

RFA-RM-18-010

*Advisory Committee to the NIH Director Working Group Findings

PI Name	Institution Name	Title
BRESTOFF, JONATHAN R	WASHINGTON UNIVERSITY	Regulation of Innate Immune Cell Responses Through Cell-to-Cell Transfer of Mitochondria
DEVRIES, ZACHARY	NORTH CAROLINA STATE UNIVERSITY RALEIGH	Histamine in Homes: Exposure Risks and Health Effects
EVRONY, GILAD DAVID	NEW YORK UNIVERSITY SCHOOL OF MEDICINE	Single-Cell Genomic Approaches to Study the Cellular Origins of Brain Tumors
JONAS, STEVEN JOHN	UNIVERSITY OF CALIFORNIA LOS ANGELES	Nanoscience-Inspired Acoustofluidic Assembly Lines for Gene and Cellular Therapies
KOSTOVA, KAMENA	CARNEGIE INSTITUTION OF WASHINGTON, D.C.	How Cells Monitor the Integrity of Their Translation Apparatus
MINA, MICHAEL J	HARVARD SCHOOL OF PUBLIC HEALTH	Deconvolution and Reconstruction of Immune Histories to Enhance Infectious Disease Prevention and Vaccination Strategies and Optimize Surveillance Efforts
RAMACHANDRAN, KAPIL	HARVARD UNIVERSITY	Molecular Determinants of Neuronal Protein Homeostasis Through Plasma Membrane-Localized Proteasome Complexes
SAMSTEIN, ROBERT M	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	Dissecting the Influence of DNA Damage Response and Homologous Recombination Deficiencies on Tumor Immunogenicity
SCHLEIDER, JESSICA LEE	STATE UNIVERSITY NEW YORK STONY BROOK	Harnessing Network Science to Personalize Scalable Interventions for Adolescent Depression
SCHULMAN, SOL	BETH ISRAEL DEACONESS MEDICAL CENTER	Functional Genetics of Tissue Factor in Bleeding and Thrombotic Risk
SHAFFER, SYDNEY	UNIVERSITY OF PENNSYLVANIA	Decoding Mechanisms of Phenotypic Memory in Single Cells
ZHANG, HAICHONG	WORCESTER POLYTECHNIC INSTITUTE	Multiparametric Photoacoustic Imaging-Based Identification of Aggressive Prostate Cancer

RFA-RM-17-008

PI Name	Institution Name	Title
BAKHOUM, SAMUEL F	SLOAN-KETTERING INST CAN RESEARCH	The Role of Chromosomal Instability in Tumor Evolution
BILAL, USAMA	DREXEL UNIVERSITY	The Health Consequences of Urban Scaling
CHAO, HSIAO-TUAN	BAYLOR COLLEGE OF MEDICINE	Illuminating GABAergic Signaling in Neurodevelopmental Disorders
DESELM, CARL	WASHINGTON UNIVERSITY	Immune Activating CAR-Modified Antigen Presenting Cells
ERB, MICHAEL A	SCRIPPS RESEARCH INSTITUTE	Targeting Crotonyl-Lysine Chromatin Readers to Disrupt Pathogenic Gene Expression in Leukemia
GOULD, ALISON	CALIFORNIA ACADEMY OF SCIENCES	Investigating Mechanisms of Specificity in a Bioluminescent Vertebrate-Bacteria Symbiosis
HEINSBROEK, JASPER	MEDICAL UNIVERSITY OF SOUTH CAROLINA	Dissecting Ventral Pallidal Subcircuit Contributions to Drug Seeking in Addiction
JAIN, ISHA HIMANI	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Redesigning a Neurons Breath: A Modern Twist to Classical Oxygen Biology
KNOUSE, KRISTIN A	WHITEHEAD INSTITUTE FOR BIOMEDICAL RES	Dissecting and Engineering Reversible Cell Cycle States
OVCHINNIKOV, SERGEY L	HARVARD UNIVERSITY	Exploring the Unknown Protein Universe Using Evolutionary Information
SELLMYER, MARK ANTHONY	UNIVERSITY OF PENNSYLVANIA	Next Generation Tools for Imaging Bacterial Infection and Its Relationship to the Immune System
WEXLER, ANNA	UNIVERSITY OF PENNSYLVANIA	Do-It-Yourself and Direct-to-Consumer Medicine and Science: Assessing the Public Health Issues and Regulatory Gaps

RFA-RM-16-006

PI Name	Institution Name	Title
ARBOLEDA, VALERIE ANNE	UNIVERSITY OF CALIFORNIA LOS ANGELES	Unraveling CorrelationsBetween Mendelian and Common Disease Using Functional Genomics
BADRAN, AHMED HUSSEIN	HARVARD UNIVERSITY	Functional Interrogation of Ribosomal Biology Using Continuous Evolution
CHEN, FEI	BROAD INSTITUTE, INC.	Characterizing Glioma Heterogeneity with Novel Multiplexed Nanoscale Imaging Technologies
EAGEN, KYLE PATRICK	NORTHWESTERN UNIVERSITY AT CHICAGO	Biochemical Basis of Chromatin Folding and Chromosome Condensation
FINUCANE, HILARY	BROAD INSTITUTE, INC.	Identifying Disease-Relevant Cell Types by Integrating Genetic and Functional Genomics Data
GYMREK, MELISSA	UNIVERSITY OF CALIFORNIA SAN DIEGO	Systematic Identification and Interpretation of Repetitive Variants Underlying Schizophrenia
LOH, KYLE M	STANFORD UNIVERSITY	Developing Approaches for Universal Organ Transplantation
MEHR, SAMUEL A	HARVARD UNIVERSITY	Psychological Functions of Music in Infancy
MORRIS, ZACHARY SCOTT	UNIVERSITY OF WISCONSIN-MADISON	Combining Radiation and Tumor-Specific Antibody Therapies to Elicit In Situ Tumor Vaccination
SONG, ZIRUI	HARVARD MEDICAL SCHOOL	Inequities in Health Outcomes in the Twenty-First Century: Understanding New Causes and the Impact of Delivery System Reforms on Health Care Disparities
ZHOU, CHUANKAI	BUCK INSTITUTE FOR RESEARCH ON AGING	Mechanism of Organelle Dysfunction During Aging and the Related Rejuvenation Process

RFA-RM-15-006

PI Name	Institution Name	Title
ABRAHAM, JONATHAN	BRIGHAM AND WOMEN'S HOSPITAL	Antibody Therapeutics for Human Viral Hemorrhagic Fevers and Prevention of Late Neurological Syndromes
BIND, MARIE-ABELE CATHERINE	HARVARD UNIVERSITY	Transporting Established Insights from Classical Experimental Design to Address Causal Questions in Environmental Epidemiology, Including the Understanding of Biological Mediating Mechanisms
BRUNKARD, JACOB O	UNIVERSITY OF CALIFORNIA BERKELEY	An Aminoacyl tRNA Synthetase is a Nitrogen Sensor that Activates TOR in Plants
DEKOSKY, BRANDON JAMES	UNIVERSITY OF KANSAS LAWRENCE	Comprehensive Analysis of Human Adaptive Immune Receptors to Elucidate Correlates of Epstein-Barr Virus Disease Suppression
DIVITO, SHERRIE JILL	BRIGHAM AND WOMEN'S HOSPITAL	Investigating a Novel Cell Population in Delayed-Onset Drug Hypersensitivity Reactions
DIXON, JESSE	SALK INSTITUTE FOR BIOLOGICAL STUDIES	Mechanisms of Formation of 3D Genome Structures
GANTZ, VALENTINO MATTEO	UNIVERSITY OF CALIFORNIA SAN DIEGO	Development, Characterization and Application of CRISPR/Cas9 Gene Drive Technologies and Related Active Genetic Elements to Benefit Research and Society at Large
GIOVENCO, DANIEL PHILIP	RBHS-SCHOOL OF PUBLIC HEALTH	Geographic Variation in the Diverse Tobacco Retail Environment and Its Impact on Tobacco Use Disparities
KOENIG, KRISTEN MARIE	HARVARD UNIVERSITY	Investigating Organ Formation and the Emergence of Complexity in the Visual System Using Comparative Developmental Approaches
MANGLIK, AASHISH	STANFORD UNIVERSITY	Molecular Mechanisms of Iron Homeostasis
MARTINEZ-BAKKER, MICAELA ELVIRA	PRINCETON UNIVERSITY	Hacking Epidemics: Unlocking the Drivers of Transmission Seasonality to Battle Vaccome-Preventable Diseases
MUGNIER, MONICA	JOHNS HOPKINS UNIVERSITY	Variant Surface Glycoprotein Diversification in Trypanosoma brucei
RAMIREZ, STEVE	HARVARD UNIVERSITY	Artificially Modulating Memories to Alleviate Psychiatric Disease-Like States
RING, AARON MICHAEL	YALE UNIVERSITY	Uncoupling Pleiotropy in the LIGHT/HVEM/LTBetaR Signaling Network
SPITZER, MATTHEW	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Quantitatively Modeling Immune Responses to Cancer
YACKLE, KEVIN	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Cellular and Molecular Identification of the Breathing Pacemaker Neurons

RFA-RM-14-004

PI Name	Institution Name	Title
BONDY-DENOMY, JOSEPH	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Discovering New Roles for CRISPR-Cas in Bacterial Pathogenesis
BRAGG, MARIE	NEW YORK UNIVERSITY SCHOOL OF MEDICINE	Impact of Racially Targeted Food and Beverage Ads on Adolescent Behavior
DEMEHRI, SHADMEHR	WASHINGTON UNIVERSITY	The Mechanism of TSLP Anti-Tumor Effects in the Skin
GADE, TERENCE P	UNIVERSITY OF PENNSYLVANIA	Image-Based Phenotyping of Hepatocellular Carcinoma Cell Survival under Ischemic Stress: Toward Metabolic Imaging of Cancer Dormancy Using Hyperpolarized Carbon-13 Technology
GEE, DYLAN	YALE UNIVERSITY	Novel Mechanisms of Fear Reduction Targeting the Biological State of the Developing Brain
GREENBLATT, MATTHEW BLAKE	WEILL MEDICAL COLL OF CORNELL UNIV	Modulation of Bone Formation by SHN3
HILL, ELAINE	UNIVERSITY OF ROCHESTER	The Health Consequences of Shale Gas Development
HSU, PATRICK DAVID	SALK INSTITUTE FOR BIOLOGICAL STUDIES	Eukaryotic Transcriptome Engineering via Sequence-Specific Regulation of Endogenous RNA
ISRAELSEN, WILLIAM JAMES	UT SOUTHWESTERN MEDICAL CENTER	Development and Use of a Novel, Tractable Rodent Model for Studies of Hibernation Metabolism
KRUSE, ANDREW	HARVARD COLLEGE	Molecular Mechanisms of Adiponectin Signaling and PAQR Function
LYUMKIS, DMITRY	SALK INSTITUTE FOR BIOLOGICAL STUDIES	Breaking Barriers in Structural Biology: Novel CryoEM Methods and Applications
MEDAGLIA, JOHN	UNIVERSITY OF PENNSYLVANIA	Dynamic Network Neuroscience and Control Theory: Toward Interventions for Cognitive Control Dysfunction
SHELTZER, JASON	COLD SPRING HARBOR LABORATORY	Identification and Characterization of Genomic Features Affecting Survival Duration in Cancer
SOLOMON, DAVID A	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Cohesin Gene Mutations in Tumorigenesis
SONABEND, ADAM M	COLUMBIA UNIVERSITY HEALTH SCIENCES	TOP2A Effects on Transcription in Gliomas: Implications for Personalized Therapy
ZHANG, ZHAO	CARNEGIE INSTITUTION OF WASHINGTON	Somatic Transposition-Mediated Genome Variegation during Development, Disease and Aging Conditions

RFA-RM-13-009

PI Name	Institution Name	Titles
ALLISON, KYLE ROUSE	COLUMBIA UNIVERSITY HEALTH SCIENCES	Isolation and Systems-Level Characterization of Persistent Bacteria
ANGELO, ROBERT MICHAEL	STANFORD UNIVERSITY	Predictive Signatures in Breast Cancer Using Multiplexed Ion Beam Imaging
BERGELSON, ELIKA	DUKE UNIVERSITY	Mechanisms of Word Learning in Infancy
CHAN, DAVID CHIMIN	PALO ALTO INSTITUTE	The Benefit and Burden of Electronic Reminders for Optimizing Patient Care
ESCOLA, GARY SEAN	COLUMBIA UNIVERSITY HEALTH SCIENCES	The Internal States of Neural Circuits: Data Analysis, Modeling, and Disease
HANNA, JOHN W	BRIGHAM AND WOMEN'S HOSPITAL	New Ubiquitin-Proteasome System Components that Protect against Proteotoxicity
HILL, ALISON LYNN	HARVARD UNIVERSITY	Quantification and Prediction of Treatment Efficacy for HIV Cure Strategies
HYSTAD, PERRY W	OREGON STATE UNIVERSITY	PURE-AIR: A Global Assessment of Air Pollution and Cardiopulmonary Disease
JUDSON, ROBERT LAIRD	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	MicroRNA-Based Detection of Barriers to Melanoma Progression
MARU, DUNCAN	BRIGHAM AND WOMEN'S HOSPITAL	Integrating Pediatric Care Delivery in Rural Healthcare Systems
MEYER, AARON SAMUEL	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Adapter-Layer RTK Signaling: Basic Understanding & Targeted DrugResistance
NELSON, ERIC JORGE	STANFORD UNIVERSITY	A Novel Approach to Improve Patient Care and Diarrheal Disease Research Using Mobile Technology
QUIROZ, YAKEEL TATIANA	MASSACHUSETTS GENERAL HOSPITAL	Memory Network Dysfunction as an Early Marker of Preclinical Alzheimers Disease
RANDLES, AMANDA E	UNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB	Toward Coupled Multiphysics Models of Hemodynamics on Leadership Systems
SANTOS, GLENN-MILO	PUBLIC HEALTH FOUNDATION ENTERPRISES	The Better THAN Study: Targeting Heavy Alcohol with Naltrexone among MSM
SIMON, NOAH	UNIVERSITY OF WASHINGTON	Data-Driven Statistical Learning with Applications to Genomics
STOWELL, SEAN	EMORY UNIVERSITY	Examination of Innate Immunity Against Molecular Mimicry

RFA-RM-12-018

PI Name	Institution Name	Titles
ALUSHIN, GREGORY M	ROCKEFELLER UNIVERSITY	Mechanosensing via Cytoskeletal Strain
BACONGUIS, ISABELLE RHYSSA JOE EDURIA	OREGON HEALTH AND SCI UNIVERSITY	Structure and Function of Epithelial Sodium Channels
BJORNSSON, HANS TOMAS	JOHNS HOPKINS UNIVERSITY	Exploring Kabuki Syndrome as a Treatable Cause of Intellectual Disability
BRUENING, MEREDITH M	ARIZONA STATE UNIVERSITY-TEMPE CAMPUS	The Role of Friendship Networks on BMI and Behaviors among College Freshmen
CARTER, HANNAH KATHRYN	UNIVERSITY OF CALIFORNIA	Network Approaches to Identify Cancer Drivers from High-Dimensional Tumor Data
DENNY, CHRISTINE ANN	COLUMBIA UNIVERSITY HEALTH SCIENCES	Optogenetic Dissection of Hippocampal Circuitry Underlying Alzheimers Disease
HSIAO, ELAINE	CALIFORNIA INSTITUTE OF TECHNOLOGY	Uncovering Microbial Modulators of Neuroactive Molecules as Novel Therapeutics
JENA, ANUPAM BAPU	HARVARD UNIVERSITY (MEDICAL SCHOOL)	Physician Determinants of Health Care Spending, Quality, and Patient Outcomes
LOURIDO, SEBASTIAN	WHITEHEAD INSTITUTE FOR BIOMEDICAL RES	Dissecting Essential Signaling Pathways in Apicomplexan Parasites
LOVELL, JONATHAN F	STATE UNIVERSITY OF NEW YORK AT BUFFALO	Targeting Tumors with Resealable Nanovesicles Permeabilized by NIR Light
LUDINGTON, WILLIAM	UNIVERSITY OF CALIFORNIA BERKELEY	Developing a Reduced Complexity Model Gut Microbiome in the Behavior Model, Drosophila, and Bacteriophage Therapies to Modulate Behavior through the Microbiome
PINCUS, DAVID	WHITEHEAD INSTITUTE FOR BIOMEDICAL RES	Quantitative Approaches to Reveal the Homeostatic Control Mechanisms of Stress Responses
QI, LEI STANLEY	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	A Novel RNA-Guided Platform for Sequence-Specific Cell Reprogramming
WANG, ERIC T	UNIVERSITY OF FLORIDA	Post-Transcriptional Regulation of Gene Expression in Neuromuscular Disease
WEINBERG, DAVID ERIC	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Formation and Regulation of the Translating mRNP

RFA-RM-11-007

PI Name	Institution Name	Titles
ANTICEVIC, ALAN	YALE UNIVERSITY	Characterizing Cognitive Impairment in Schizophrenia via Computational Modeling and Pharmacological Neuroimaging
BATISH, MONA	UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL	Detection of Chromosomal Translocations by Single Molecule RNA Imaging
CHEN, YVONNE	UNIVERSITY OF CALIFORNIA LOS ANGELES	Engineering of Computational Receptors and Gene Circuits for T-cell Immunotherapy
DE LA ZERDA, ADAM	STANFORD UNIVERSITY	Molecular Imaging of Protein Glycosylation in Living Subjects
FORNWALT, BRANDON K	UNIVERSITY OF KENTUCKY	Exploring the Role of Dyssynchrony in Pediatric Heart Disease with MRI
GUTTMAN, MITCHELL	BROAD INSTITUTE, INC.	Deciphering the Mechanism of Large ncRNA Mediated Regulation of Cell State
KAISER, WILLIAM JOSEPH	EMORY UNIVERSITY	RIP1 and RIP3 rRegulation of Apoptosis, Necrosis, and Inflammation
OBERMEYER, ZIAD	BRIGHAM AND WOMEN'S HOSPITAL	Unexpected Death after Medical Encounters: Measurement, Reporting, and Analysis
ROSENBERG, BRAD	ROCKEFELLER UNIVERSITY	Immune Profiling by High Throughput Sequencing of Complete Antigen Receptors
SONNENBERG, GREGORY F	UNIVERSITY OF PENNSYLVANIA	Regulation of Host-Commensal Relationships in Human Health and Disease
THOMSON, MATTHEW	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Quantitative Models for Controlling Collective Cell Fate Selection in Stem Cells
VICTORA, GABRIEL D	WHITEHEAD INSTITUTE FOR BIOMEDICAL RES	In Vivo Approaches to Dissecting B Cell-T Cell Cooperation in Germinal Centers
VILLEDA, SAUL A	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Regulation of Neurogenesis and Cognition by Systemic Age-Related Immune Factors
YEH, ELLEN	STANFORD UNIVERSITY	Defining the Novel Eukaryotic Biology of the Apicomplexan Plastid

RFA-RM-10-019

PI Name	Institution Name	Titles
BASTA, NICOLE ELAINE	UNIVERSITY OF WASHINGTON	Antibody Persistence after Conjugate Meningococcal Group A Vaccination in Mali
CALARCO, JOHN ANTHONY	HARVARD UNIVERSITY	Investigating the Role of Alternative Splicing Regulatory Networks in Nervous System Development and Function
FRASER, JAMES SOLOMON	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	The Impact of Mutation on the Conformations and Recognition of Ubiquitin
HALFMANN, RANDAL ARTHUR	UNIVERSITY OF TEXAS SW MED CTR/DALLAS	Contributions of Protein Aggregation to Gene Regulation and Phenotypic Diversity
KIDD, JEFFREY M	STANFORD UNIVERSITY	Characterizing the Global Architecture of Genomic Diversity
LEPPER, CHRISTOPH	CARNEGIE INSTITUTION OF WASHINGTON, D.C.	Molecular Mechanisms of Muscle Stem Cells Transitioning Intoquiescence
OLSEN, CARISSA	FRED HUTCHINSON CANCER RESEARCH CENTER	Defining the Impact of Lipid Synthesis and Turnover on Aging in C. elegans
SAMACO, RODNEY C	BAYLOR COLLEGE OF MEDICINE	The Genetic and Neuroanatomical Origin of Social Behavior
WANG, HARRIS H	HARVARD UNIVERSITY (MEDICAL SCHOOL)	Functional Metagenomic Reprogramming of the Human Microbiome through Mobilome Engineering
WITTEN, DANIELA	UNIVERSITY OF WASHINGTON	High-Dimensional Unsupervised Learning, with Applications to Genomics

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2025 NIH Director's Early Independence Award (DP5)

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