From protein folding to cognition: a serendipitous path of discovery

4ce63d7b15fffd656532e83f7fd37bc7 University of California, San Francisco {"start": "2017-04-19T19:00:00", "end": "2017-04-19T20:00:00"}

Peter Walter, Ph.D.
Walter, Peter, Ph.D. Principal Investigator

A screen for small molecule modulators of the unfolded protein response yielded ISRIB, a drug-like compound that with high efficacy renders cells insensitive to translational inhibition by phosphorylation of eIF2. ISRIB is an activator of eIF2B, eIF2’s guanine nucleotide exchange factor, and a cognitive enhancer in rodents, significantly improving long-term memory of wild-type animals in behavioral assays.

https://videocast.nih.gov/watch=22145 http://walterlab.ucsf.edu/