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Convene an advisory meeting to evaluate how assays and best practices developed in the context of the NIH Common Fund Science of Behavior Change and other related NIH activities could be incorporated into the design of primary prevention trials or for clinical trials targeting risk factors associated with increased risk of AD and AD-related dementias.
2020 RFA-AG-20-024: Science of Behavior Change (SOBC) Resource and Coordinating Center 10.F Achieved Convene an advisory meeting to evaluate how assays and best practices developed in the context of the NIH Common Fund Science of Behavior Change... DN 2012 AD Summit: 5E 2017 Dementia Care Summit Workshop: NASEM Expert Meeting (June 2017): Understanding Pathways to Successful Aging - Behavioral and Social Factors Related to Alzheimer's Disease: Proceedings of a Workshop–in Brief Trial Design SOBC Resource and Coordinating Center SOBC Measures Repository Research Centers Collaborative Network of the NIA Webinar Series: Mechanisms of Behavior Change for Healthy Aging, May 8, 2019 Projects funded under RFA-AG-22-016 in FY22 RFA-AG-23-034 Mechanism-Focused Research to Promote Adherence to Healthful Behaviors to Prevent Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD) and AD-Related Dementias (ADRD) (R61/R33 Clinical Trial Required) (Reissue of RFA-AG-22-016)
Generate recommendations that would guide the inclusion of behavioral target engagement assays and best practices in NIH-supported prevention and treatment trials for AD and AD-related dementias.
Use results to inform the design of mid-life prevention trials in populations with high levels of behavioral/health profile AD risk.
Summary of Key Accomplishments
NIA supported an expert panel meeting in 2019 to explore the idea of approaching the development of primary prevention trials for AD/ADRD with deliberate attention to discovering the specific reasons behind successful behavior change. The goal of the workshop was to inform research efforts to increase adherence to AD prevention interventions. The recommendations generated by the panel informed two research funding opportunities (RFA-AG-22-016 and PAR-21-207) focused on approaches to promote initiation and long-term maintenance of lifestyle changes linked to AD risk prevention.
The key accomplishments summary is current as of March 2022.