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AD-Related Dementias Focus
Promote collaboration among TBI and dementia researchers through working groups, retrospective and prospective data and measurement harmonization, and interdisciplinary research.
2031 RFA-NS-19-026: Clinical and Biological Measures of TBI-related dementia including Chronic Traumatic Encephalopathy (CTE) (R01) RFA-NS-19-030: Neuropathological Assessment of TBI-related Neurodegeneration and Neurocognitive Decline - Center Without Walls (NATBI CWOW) (U54) NOT-AG-20-043: Administrative Supplements for NIA-VA Mentored Physician-Scientist Award in Alzheimer’s Disease and its Related Dementias (AD/ADRD) NOT-NS-22-002: Adding TBI Assessments to AD/ADRD Cohorts RFA-NS-23-002: Tools and resources to understand the vascular pathophysiology of in vivo neuroimaging findings in TBI-related dementia and/or VCID (U24 - Clinical Trials Not Allowed) 1.N In Progress Encourage crosstalk and interdisciplinary collaboration between TBI and dementia researchers. DN 2019 ADRD Summit: Emerging Scientific Topics, Focus Area 2: TBI and AD/ADRD Risk, Milestone 5 2022 ADRD Summit: Multiple Etiology Dementias (MED) Special Topic: Post-TBI AD/ADRD Milestone 1, Priority 1 Workshop: NINDS TBI Classification and Nomenclature Population Studies and Precision Medicine NINDS Common Data Element Program Federal Interagency TBI Research (FITBIR) database Clinical and Biological Measures of TBI-related dementia including Chronic Traumatic Encephalopathy (CTE) (R01) Neuropathological Assessment of TBI-related Neurodegeneration and Neurocognitive Decline - Center Without Walls (NATBI CWOW) (U54) The Neuropathological Diagnosis of Chronic Traumatic Encephalopathy (CTE): Next Steps Select projects funded in FY21 Select projects funded in FY22
- Convene a meeting of TBI and AD/ADRD researchers including trainees and other interdisciplinary researchers with a focus on data harmonization and data sharing.
- Add TBI assessments to at least one AD/ADRD cohort study.
- Add AD/ADRD assessments to at least one TBI cohort study.
Summary of Key Accomplishments
NIH’s AD/ADRD program is exploring opportunities to develop cross-training and career enhancement programs such as K (PAR 19-238) awards. These opportunities have the potential to bring junior researchers with a diverse scientific background (e.g., TBI) into the field of AD/ADRD. In an effort to encourage interdisciplinary collaborations, NINDS also seeks opportunities to support existing TBI and AD/ADRD cohort studies such as NOT-NS-22-002.
The key accomplishments summary is current as of July 2022.