Population Studies: Exposome studies and health disparities

Expand current efforts to address health disparities research questions relevant to AD/ADRD by leveraging new and existing exposome AD/ADRD studies, including the impact of institutional and policy-level drivers of health inequities in AD/ADRD risk (i.e., factors categorized as forms of structural racism).

2026 NOT-AG-21-033: Health Disparities and Alzheimer's Disease NOT-AG-22-022: Administrative Supplements to Support Research Infrastructure on Exposome Studies in Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) RFA-AG-23-020: Building Infrastructure for Precision Medicine Research on Minority Health and Disparities in Alzheimer’s Disease (AD) and AD-Related Dementias (ADRD) (UH2/UH3 Clinical Trial Not Allowed) PAR-23-112: Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities (R01 - Clinical Trial Optional) RFA-AG-24-010: Limited Competition: The Health and Retirement Study and Harmonized Cognitive Assessment Protocol (U01 Clinical Trial Not Allowed) (Reissue of RFA-AG-18-005) RFA-AG-24-011: Research Coordinating Center on the Exposome and AD/ADRD: Elucidating the Role of Social and Behavioral Determinants of Health in AD/ADRD Etiology and Disparities RFA-AG-24-032: Enhancing Use of Harmonized Cognitive Assessment Protocol Data (R01 Clinical Trial Not Allowed) RFA-AG-23-020: Building Infrastructure for Precision Medicine Research on Minority Health and Disparities in Alzheimer’s Disease (AD) and AD-Related Dementias RFA-AG-24-022: Quantifying the Impact of Environmental Toxicants on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) Risk in Cohort Studies (U01 Clinical Trial Not Allowed) RFA-AG-24-027: Building Neuroscience Research Infrastructure for Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) in Africa (UG3/UH3 Clinical Trial Not Allowed) RFA-AG-25-025: Short Courses promoting cross-national analyses using data from the International Health and Retirement Study (HRS) and Harmonized Cognitive Assessment Protocol (HCAP) (R25 Clinical Trial Not allowed) RFA-AG-25-007: Centers on the Demography and Economics of Aging and Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (P30 Clinical Trial Optional) RFA-AG-25-008: Centers on the Demography and Economics of Aging and Alzheimer’s Disease and Alzheimer’s Disease Related Dementias Coordinating Center (U24 Clinical Trial Optional) 1.P Achieved DN 2021 AD Summit: 7.B Workshop: Toward Health Equity in Brain Aging: Nontraditional Data Sources and Innovative Tools Highlight: Education and gender inequality may explain why India’s women have worse late-life cognition Workshop: Investigation of "well-established" risk factors for cognitive decline and Alzheimer’s disease in Black Americans, plus a call for health equity research Workshop: Public Health Research and Surveillance Priorities from the East Palestine, Ohio Train Derailment: A Workshop, supported by NIEHS and NIA Workshop: Promoting Inclusion of Sexual and Gender Minority Populations in Alzheimer’s Disease and Aging Research Highlight: Air pollution from different emission sources is associated with incident dementia Webinar: Illuminating Alzheimer’s Disease Genetic Architecture via Diversity: Alzheimer’s Disease Sequencing Project (ADSP) Diversity Initiative and Asian Cohort for Alzheimer’s Disease (ACAD) Workshop: The Future of Population-Based Studies in Alzheimer’s Disease and Related Dementia Research: Setting Future Scientific Priorities Webinar: Addressing the Disparities in Dementia Risk, Early Detection and Care in U.S. Latino Populations Webinar: Examination of vascular and Alzheimer’s dementias in community-based American Indians: Lessons learned from the Strong Heart Study Workshop: NASEM/CPOP Early Life Exposures Midlife Structural Solutions Population Studies and Precision Medicine The Influence of Structural Racism on Incidence of Alzheimer's Disease and Related Dementias (ADRD) in Black women Supplements funded under NOT-AG-22-022 in FY22 Gateway Environmental Exposome Dashboard Gateway Exposome Coordinating Center

• Develop and promote practical and effective ways to improve population-representativeness of AD/ADRD research resources, ensuring wide-spread inclusivity across all groups, including NIH-designated priority populations (including, but not limited to, race, ethnicity, nativity, gender, immigration status, sexual orientation, gender identity, socioeconomic status).
• Ensure that AD/ADRD research resources include the collection of data relevant to addressing health disparities research questions relevant to AD/ADRD.