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Create new research programs that use data-driven, network biology approaches aimed at understanding the (epi)genetics and complex biology of cognitive resilience in individuals with high genetic risk for dementia and in individuals with exceptional longevity.
2020 PAR-17-047: Selective Cell and Network Vulnerability in Aging and Alzheimer’s Disease (R01) PAR-18-706: Selective Cell and Network Vulnerability in Aging and Alzheimer’s Disease (R01) PAR-17-054: Leveraging Existing Cohort Studies to Clarify Risk and Protective Factors for Alzheimer’s Disease and Related Dementias (R01) RFA-AG-17-061: Interdisciplinary Research to Understand the Complex Biology of Resilience to Alzheimer’s Disease Risk (R01) RFA-AG-18-029: Interdisciplinary Research to Understand the Complex Biology of Resilience to Alzheimer’s Disease Risk (R01) RFA-AG-18-024: Collaboratory on Research Definitions for Cognitive Reserve and Resilience to Alzheimer's Disease (R24) RFA-AG-19-025: Development of Personalized In Vitro Assays to Quantitatively Assess Age-related Changes in Cellular Resiliencies to Physiologic Stressors (R43/R44) RFA-AG-19-026: Development of Personalized In Vitro Assays to Quantitatively Assess Age-related Changes in Cellular Resiliencies to Physiologic Stressors (R41/42) PAR-19-269: Cognitive Systems Analysis of Alzheimer's Disease Genetic and Phenotypic Data (U01 Clinical Trial Not Allowed) NOT-AG-19-017: Inviting comments and suggestions for the development of the NIA Longitudinal Rat Resource to study neural and behavioral trajectories of successful cognitive aging RFA-AG-19-011: Integrative Omics to Enhance Therapeutics Development for Healthy Aging (UH2/UH3 Clinical Trial Not Allowed) RFA-AG-23-001: Understanding the Role of Bilingualism in Cognitive Reserve/Resilience in Aging and AD/ADRD (R01 Clinical Trial Optional) 2.K Achieved Create new research programs that use data-driven, network biology approaches aimed at understanding the (epi)genetics and complex biology of cognitive resilience... DN 2015 AD Summit: 2B and 3G Workshop: Reserve & Resilience R24 Blog: Cognitive reserve research reaches for the STARRRS News: New study points to targetable protective factor in Alzheimer's disease Workshop (#2): Research Definitions for Reserve and Resilience in Cognitive Aging and Dementia News: Cognitive super agers defy typical age-related decline in brainpower News: Higher levels of education may help preserve memory in the face of accumulating age-related brain pathology News: Genetic clues found for cognitive resilience to Alzheimer’s disease Workshop on Research Definitions for Reserve and Resilience in Cognitive Aging & Dementia Workshop: Understanding Cerebellar Contributions to Cognitive and Affective Functions in Aging and AD/ADRD Highlight: Taking a deep dive into the Alzheimer’s brain in search of understanding and new targets Workshop: Cognitive Aging Summit IV Research on Disease Mechanisms Collaboratory on Research Definitions for Cognitive Reserve and Resilience to Alzheimer's Disease Resilience AD Program ELP: Exceptional Longevity Portal The Integrative Longevity Omics Projects UC Irvine ADRC 90+ Cohort – Neuropathology Core Genetic Resilience to the Clinical Manifestation of Dementia Genetic Drivers of Resilience to Alzheimer's Disease The Stanford Extreme Phenotypes in Alzheimer's Disease (StEP AD) Cohort Cognitive Aging Summit III Special Issue of Neurobiology of Aging Highlighting the Cognitive Aging Summit III Resilience/Resistance to Alzheimer's Disease in Centenarians and Offspring (RADCO) Cognitive Superager Networks: Study to Uncover Pathways to Exceptional Cognitive Resilience in Aging (SUPERAging) Cognitive Superager Networks: Resilience/Resistance to Alzheimer's Disease in Centenarians and Offspring (RADCO) Precision Aging Network 2016
- Launch at least 6 research projects aimed at identifying molecular networks causally linked to cognitive resilience as potential therapeutic targets for disease prevention. These efforts should support the preclinical validation of the identified targets.
Summary of Key Accomplishments
The development of effective treatment and prevention for complex diseases such as AD can benefit from a deeper understanding of which genetic, environmental, social, and behavioral factors promote wellness and resilience against disease. Established through a targeted research initiative, the Resilience-AD Program supports 10 cross-disciplinary projects using a big data approach to understand why some individuals who are at high risk of AD due to genetic factors (two copies of ApoE4), very old age (90+, centenarians) or the presence of AD biomarkers (accumulation of amyloid and tau in the brain) remain dementia-free compared to their peers. Research supported through this program has identified several new biological pathways that may protect the brain from the effects of amyloid accumulation, such as genes involved in bile acid metabolism.
The key accomplishments summary is current as of March 2022.