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Dates
Oct. 29, 2024 | 8:30 a.m.-5:30 p.m. ET
Oct. 30, 2024 | 9:00 a.m.-1:00 p.m. ET
Location
This hybrid workshop will be available for participants to join virtually through Zoom.
Purpose and Background
This workshop aims to bring together leading researchers and experts to discuss recent advancements and challenges in understanding the molecular and cellular mechanisms responsible for the differential accumulation and propagation of tau and amyloid strains in Alzheimer's disease.
The workshop will center around the following key research areas:
- Functional annotation of cellular and biochemical pathways specifically associated with the self-assembly, propagation, and clearance of amyloid strains.
- Identification of potential co-factors and receptors involved in modulating the uptake and propagation of amyloid strains in recipient cells.
- Development of strain-specific imaging compounds and antibodies to establish correlations between strain heterogeneity and patient-to-patient variations.
- Utilizing cryo-electron microscopy (CryoEM) and cryo-electron tomography (CryoET) combined with structure-based design to identify novel approaches that redirect or inhibit the aggregation process of rapid and aggressive amyloid strains.
Registration
Please register for this workshop in advance.
Agenda
Note: This agenda is in Eastern Time.
Day 1 | Tuesday, Oct. 29, 2024
8:30 a.m. Welcome and Introductions
8:40 a.m. Neuropathological heterogeneity and copathology in neurodegenerative diseases: implications, Lea Grinberg, University of California, San Francisco
9:10 a.m. The role of heterotypic amyloid interactions in shaping amyloid polymorphism, Joost Schymkowitz, Katholieke Universiteit Leuven
9:40 a.m. How cyro-EM structures of amyloids will keep informing research into neurodegeneration, Sjors Scheres, MRC-Laboratory of Molecular Biology, Cambridge University
10:10 a.m. Break
10:20 a.m. CryoEM-based discovery of small molecules that disassemble brain-derived pathological fibrils of tau and alpha-synuclein, David Eisenberg, University of California, Los Angeles
10:50 a.m. A macrocyclic peptide platform for the discovery of functional tau epitopes, Juan Del Valle, University of Notre Dame
11:20 a.m. Native mass spectrometry as a tool for single particle cryo-EM sample preparation, Joshua Coon, University of Wisconsin-Madison
11:50 a.m. Lunch
12:50 p.m. Molecular structure within human AD brain by fluorescence-guided, in-tissue CryoET, Rene Frank, University of Leeds
1:20 p.m. Utilizing CryoEM and CryoET together with structural-based design to identify novel approaches that redirect or inhibit the aggregation process of rapid and aggressive amyloid strains, Sarah Shahmoradian, University of Texas Southwestern Medical Center
1:50 p.m. Reconstructing Alzheimer's disease tau by solid-state nuclear magnetic resonance, Mei Hong, Massachusetts Institute of Technology
2:20 p.m. Cofactors as triggers of tau aggregation, Jeffery Kuret, Ohio State University
2:50 p.m. Break
3:00 p.m. Recognition of amyloid structures by monoclonal antibodies, Charles Glabe, University of California, Irvine
3:30 p.m. Endogenously generated Dutch-type amyloid beta oligomers dysregulate presynaptic neurotransmission in the absence of detectable inflammation, Samuel Gandy, Icahn School of Medicine at Mount Sinai
4:00 p.m. Functional genetic classification of tau prion strains, Marc Diamond, University of Texas Southwestern Medical Center
4:30 p.m. Uncovering cellular pathways promoting differential tau strain accumulation and clearance by CRISPR screens, Martin Kampmann, University of California, San Francisco
5:00 p.m. Group Discussion
5:30 p.m. Adjourn Day 1
Day 2 | Wednesday, Oct.30, 2024
9:00 a.m. Differential mechanisms of toxicity of tau in AD/ADRD: insights from targeted mice, Karen Duff, University College of London
9:30 a.m. Properties of fibrillar and nonfibrillar tau, Bradley Hyman, Massachusetts General Hospital, Harvard University
10:00 a.m. Brain-derived tau polymorphs stability profile and interactome potential to differentiate disease phenotype, Rakez Kayed, University of Texas Medical Branch
10:30 a.m. Tau escape from lysosomes and its counteraction by endosomal sorting complexes required for transport (ESCRT) proteins, James Hurley, University of California, Berkeley
11:00 a.m. Constitutively compromised neuronal endo-lysosomes and degenerative brain disorder, Tomas Kirchhausen, Harvard University
11:30 a.m. Group Discussion
12:30 p.m. Closing Remarks
1:00 p.m. Adjourn Day 2
Contact Information
Please contact Austin Yang at austin.yang@nih.gov or Chelsea Haakenson at chelsea.haakenson@nih.gov for questions you may have about the workshop.
Reasonable Accommodations: If you need reasonable accommodation to participate in this event, please contact the meeting organizer listed under Contact information. Please make your request no later than 1 week before the event.