Current Progress and New Directions in Delirium Research

Day 1 | Monday, August 5

1:00 p.m. Keynote Address, E. Wesley Ely, M.D., M.P.H., Vanderbilt University Medical Center

1:00 p.m. Welcome and Introductions: Molly Wagster, Ph.D. National Institute on Aging

• Keynote Address, “Where am I going? Who am I going with?”, E. Wesley Ely, M.D., M.P.H., Vanderbilt University Medical Center

1:45 p.m. Break

2:00 p.m. Session I | Delirium Outcomes
Moderator: Miles Berger, M.D., Ph.D., Duke University Medical Center

• Patient Outcomes after Delirium Screening in skilled nursing facilities, Becky A Briesacher, Ph.D., Associate Professor, School of Pharmacy, Northeastern University
• Sleep Optimization for Brain Health and Postoperative Delirium in Older Surgical Patients, Lei Gao, M.B.B.S., Massachusetts General Hospital
• Methylomics, Transcriptomics, and Proteomics in Delirium: Unveiling Biomarkers for Diagnosis and Stratification, Oluwaseun Johnson-Akeju, M.D., Massachusetts General Hospital
• Neural Markers of Delirium Vulnerability Spanning Sleep and Wakefulness, Ben Julian Palanca, M.D., Ph.D., Washington University
• Delirium and Frailty: Vulnerability Across the Continuum of Critical Illness, Nathan A Brummel, M.D., Ohio State University
• Tech Enabled Exercise to Old School Medications: New Approaches to Preventing and Treating Delirium and Cognitive Impairment, Christopher Hughes, M.D., Vanderbilt University Medical Center
  

3:45 p.m. Break

4:00 p.m. Session 2 | Basic Brain Mechanisms Underlying Delirium

• Pathogenesis of postoperative delirium: focus on neuroimmune interactions, Niccolo Terrando, Ph.D., Duke University
• Targeting Glial Glutamate Signaling in Delirium, Atsushi Kamiya, MD, Ph.D., The Johns Hopkins University School of Medicine
• Unraveling the Role of Polyamine Metabolism in Post-Operative Delirium: Exploring Biochemical Mechanisms and Biomarker Potential, Stewart F Graham, Ph.D., Oakland University-William Beaumont School of Medicine
• The Role of Estrogen and Interleukin-6 Signaling in Delirium, Shouri Lahiri, M.D., Cedars-Sinai Medical Center

5:30 p.m. Discussion and Wrap-up

5:45 p.m. Adjourn

Day 2 | Tuesday, August 6

9:00 a.m. Session 3 | Delirium Prevention
Moderator: Oluwaseun Johnson-Akeju, M.D., Massachusetts General Hospital

• Rationale and Scientific Findings of a Perioperative Cognitive Anesthesia Network Program for ADRD and Delirium Prevention, Catherine E Price, Ph.D., University of Florida
• ‘ICU Delirium Playbook’ to Optimize Delirium Detection and Prevention in Older Critically Ill Patients, Biren Kamdar, M.D., University of California, San Diego (UCSD) Health
• Geroscience approaches to understanding delirium, John C. Newman, M.D., Ph.D., Buck Institute for Research on Aging

10:15 a.m. Break

10:30 a.m. Session 4 | Delirium Prediction
Moderator: Ben Julian Palanca, M.D., Ph.D., Washington University

• Neurocognitive disorder risk across the spectrum of common surgeries in older adults, Elizabeth Louisa Whitlock, M.D., University of California, San Francisco
• Developing EEG-based biomarkers of delirium, Shawniqua Williams Roberson, MEng, M.D., Vanderbilt University
• Identifying a Vulnerable Brain to Understand Delirium Pathophysiology, Sarinnapha Vasunilashorn, Ph.D., Beth Israel Deaconess Medical Center
• Anesthesia as a Stress Test: Using EEG to Identify Latent Brain Abnormalities that Lead to Delirium, Miles Berger, M.D., Ph.D., Duke University Medical Center
• Methylomics, Transcriptomics, and Proteomics in Delirium: Unveiling Biomarkers for Diagnosis and Stratification, Oluwaseun Johnson-Akeju, M.D., Massachusetts General Hospital
  

12:15 p.m. Break

12:30 p.m. Roundtable Discussion (Closed)

1:30 Adjourn