2021 NIH Alzheimer's Research Summit: Agenda

10:00 a.m. - 10:45 a.m. Introductory Remarks

• Francis Collins, Director, NIH
• Richard Hodes, Director, NIA/NIH
• Eliezer Masliah, Director, Division of Neuroscience, NIA/NIH

10:45 a.m. - 11:45 a.m. Plenary Talks

Understanding the Impact of Health Disparities to Enable Precision Medicine for Dementia
Lisa Barnes, Rush University

New Mechanistic Insights and Technologies for Precision Medicine Research on Aging and Alzheimer’s
Nathan Price, Onegevity, a division of Thorne HealthTech

11:45 a.m. - 3:30 p.m. SESSION ONE | Deconstructing Disease Complexity: from Populations to Single Cells, from Genes to Multiscale Models

Chairs: Catherine Kaczorowski (Jackson Laboratory) and David Bennett (Rush University)

Speakers:

• Resolving the Complex Genetics of Alzheimer’s
  Alison Goate, Icahn School of Medicine at Mount Sinai

• Developing Multiscale Models of Alzheimer's Risk and Resilience
  Philip De Jager, Columbia University

• Single-cell Dissection of Human Disease Circuitry in Neurodegeneration
  Manolis Kellis, Massachusetts Institute of Technology

• Molecular Basis of the Clinical Heterogeneity in Early-Onset AD
  Jennifer Yokoyama, University of California, San Francisco

• Mapping the Molecular Trajectories of Aging to Understand Mechanisms of Neurodegeneration
  Tony Wyss-Coray, Stanford University

• A Tale of Two Systems: Lessons from Mid-Life Aging with Implications for Alzheimer’s Prevention and Treatment
  Roberta Diaz Brinton, University of Arizona

2:45 p.m. - 3:30 p.m. Moderated Discussion and Open Forum

10:00 a.m. - 12:30 p.m. SESSION TWO | Enabling Infrastructure and Incentives to Improve Research Rigor, Reproducibility and Translatability

Chairs: Lara Mangravite (Sage Bionetworks) and Stacey Rizzo (University of Pittsburgh)

Speakers:

• Enhancing Reproducibility and Rigor in Animal Research
  Lawrence Tabak, NIH

• AD Knowledge Portal and Agora: an Integrated FAIR Data Infrastructure for Aging and Dementia Research
  Anna Greenwood, Sage Bionetworks

• NIAGADS Data Resources and Harmonization of AD Genetic, Epidemiologic and Clinical Data
  Li-San Wang, University of Pennsylvania and Timothy Hohman, Vanderbilt University

• NCRAD: Biobanking to Enable Reproducible Precision Medicine Research in AD and Related Dementias
  Tatiana Foroud, Indiana University

• Improving Preclinical to Clinical Translation: AlzPED and MODEL-AD Preclinical Efficacy Testing Pipeline
  Stacey Rizzo, University of Pittsburgh

11:15 a.m. - 11:45 a.m. Open Forum

11:45 a.m. - 12:30 p.m. FUNDERS FORUM | Aligning Funding Incentives to Promote Transparent, Reproducible and Collaborative Research

Moderator: Suzana Petanceska, NIA

• Katja Brose, Chan Zuckerberg Initiativen

• Todd Sherer, Michael J. Fox Foundation

• Howard Fillit, Alzheimer's Drug Discovery Foundation

• Penny Dacks, Association for Frontotemporal Degeneration

• Angela Taylor, Lewy Body Dementia Association

• Tetsuyuki Maruyama, Alzheimer's Disease Data Initiative

• Heather Snyder, Alzheimer's Association

12:30 p.m. - 12:45 p.m. Break

12:45 p.m. - 3:30 p.m. SESSION THREE | Accelerating Therapy Development: Open Science from Targets to Trials

Chairs: Rebecca Edelmayer (Alzheimer's Association) and Maria Quinton (Takeda)

Speakers:

• AMP AD Target Discovery Program
  Nilufer Ertekin-Taner, Mayo Clinic

• Accelerating Therapy Development for AD/ADRD Through the MODEL-AD Open Science Consortium
  Bruce Lamb, Indiana University

• TREAT-AD Centers: Accelerating Drug Discovery for Novel Targets through Open Science
  Alan Palkowitz, Indiana University

• Raising the Bar on Data Sharing in Clinical Trials
  Reisa Sperling, Brigham and Women's Hospital, Harvard University Paul Aisen, University of Southern California

• Open Drug Discovery - A Path to Generate New, Affordable Medicines for Alzheimer's Disease
  Aled Edwards, Structural Genomics Consortium, University of Toronto

2:45 p.m. - 3:30 p.m. Open Forum

10:00 a.m. - 12:45 p.m. SESSION FOUR | Diversifying the Therapeutic Pipeline to Develop Precision Medicines

Chairs: Frank Longo (Stanford University) and Kelly Bales (Voyager Therapeutics)

Speakers:

• Delivering Probes and Clinical Candidates to Test Precision Medicine Therapeutic Hypotheses in AD
  Martin Watterson, Northwestern University

• Targeting the Epichaperome in AD
  Gabriela Chiosis, Memorial Sloan Kettering Cancer Center

• Developing MAS Receptor Agonists for the Treatment of Cognitive Impairment in AD and VCID
  Meredith Hay, University of Arizona

• Stem-Cells Based Therapy for AD
  Lisa McGinley, University of Michigan

• Biologic and Small Molecule Strategies Targeting Pyroglutamate Amyloid Beta for the Treatment of AD
  Cynthia Lemere, Harvard University

Lightning Round Presentations

• Susan Catalano, Cognition Therapeutics

• Michael Agadjanyan, Institute for Molecular Medicine

• Eugenia Trushina, Mayo Clinic

• Pam Maher, Salk Institute

• May Khanna, University of Arizona

• Dani Brunner, PsychoGenics

• Jinhe Li, Green Valley

11:30 a.m. - 12:00 p.m. Open Forum

12:00 p.m. - 12:45 p.m. PANEL DISCUSSION | Diversifying the Translational Workforce and Clinical Trials Recruitment

Moderators: Laurie Ryan, NIA and Michelle Jones-London, NINDS

• Rema Raman, University of Southern California

• May Khanna, University of Arizona

• Stephanie Monroe, UsAgainstAlzheimer's

• Jonathan Jackson, Harvard University

• Gerren Wilson, Genentech

• Carl Hill, Alzheimer's Association

12:45 p.m. - 1:00 p.m. Break

1:00 p.m. - 3:30 p.m. SESSION FIVE | Emerging Biomarkers Landscape

Chairs: Andrew Saykin (Indiana University) and Susan Catalano (Cognition Therapeutics)

Speakers:

• Session Opening Remarks: Developing Biomarkers to Enable Precision Medicine for Dementia
  Janet Woodcock, FDA

• Innovating Methods for Developing New PET Ligands for Neurological Disorders
  Neil Vasdev, Centre for Addiction and Mental Health, University of Toronto

• Evaluating AT(N) in Diverse Cohorts and in Down Syndrome
  Sid O'Bryant, University of North Texas Health Science Center

• New Plasma Tau Biomarkers
  Oskar Hansson, Lund University

• Round Robin Trials to Validate Plasma ATN Assays
  Henrik Zetterberg, University of Gothenburg

• Discovery of Omics Biomarkers for Patient Stratification
  Nicholas Seyfried, Emory University
  Rima Kaddurah-Daouk, Duke University

• Digital Biomarkers
  Graham Jones, Novartis
  Rhoda Au, Boston University

2:45 p.m. - 3:30 p.m. Moderated Discussion and Open Forum

10:00 a.m. - 12:30 p.m. SESSION SIX | Advancing Drug Repurposing and Combination Therapy Development

Chairs: Marina Sirota (University of California, San Francisco) and Roberta Diaz Brinton (University of Arizona)

Speakers:

• Low Dose Levetiracatem Formulation to Slow the Progression of MCI in AD
  Richard Mohs, AgeneBio

• ApoE Genotype-Directed Drug Repositioning and Combination Therapy for Alzheimer's Disease
  Marina Sirota, University of California, San Francisco

• Harnessing Network Medicine for Alzheimer's Drug Repurposing
  Feixiong Cheng, Cleveland Clinic Lerner Research Institute

• Leveraging the Human Non-Coding Transcriptome and Deep Learning to Advance Drug Repurposing for AD
  Claes Wahlestedt, University of Miami

• A Precision Medicine Model for Targeted NSAID Therapy in Alzheimer's Disease
  Robert Rissman, University of California, San Diego

• Using Virtual Reality to Advance Combination Therapy for MCI
  Judy Pa, University of Southern California

• Personalized Multidomain Approach to Risk Reduction for AD Prevention
  Kristine Yaffe, University of California, San Francisco

• Non-Pharmacological Interventions for AD Treatment and Prevention in the Era of Precision Medicine
  Laura Baker, Wake Forest University

11:45 a.m. - 12:30 p.m. Moderated Discussion and Open Forum

12:30 p.m. - 12:45 p.m. Break

12:45 p.m. - 3:30 p.m. SESSION SEVEN | Understanding the Impact of the Exposome on Brain Health to Advance Disease Prevention

Chairs: Amy JH Kind (University of Wisconsin) and Rachel Whitmer (University of California, Davis)

Speakers:

• The Exposome and Health: From Populations to Molecules
  Gary Miller, Columbia University

• Embedding Mobile Health and Deep Learning into Prospective Cohort Studies
  Peter James, Harvard Medical School and Harvard Pilgrim Health Care Institute and Harvard TH Chan School of Public Health

• Quantifying the Socioeconomic Impact on Brain Health - The Neighborhood Atlas
  Amy JH Kind, University of Wisconsin

• The Impact of Experiential and Lifestyle Factors on Cognitive Decline and Dementia
  David Bennett, Rush University

• The Role of the Microbiome in Aging and AD: The Alzheimer's Gut Microbiome Project
  Rob Knight, University of California, San Diego

2:30 p.m. - 3:30 p.m. Moderated Discussion and Open Forum

3:30 p.m. - 3:45 p.m. Societal Impact of Increased Funding for Women's Health Research in AD/ADRD: The Women's Health Access Matters (WHAM!) Report

• Meryl Comer, UsAgainstAlzheimer's
• Lori Frank, RAND Corporation

3:45 p.m. - 4:00 p.m. Closing Remarks

Allan Levey, Co-Chair, National Alzheimer's Project Act Advisory Council on Alzheimer's Research Care and Services

DN