Cellular Quiescence, Senescence, and Death in Aging and Longevity

Human cell being destroyed

Audience

Researchers and clinicians at all career stages who are interested in cell fate determination and how the process changes with age.

Dates

April 23, 2024 | 10:00 a.m. – 5:00 p.m. ET

Purpose and Background

The Division of Aging Biology (DAB) at NIA hosted a virtual one-day workshop to explore cellular decisions around fate determinations in aging. Workshop speakers discussed the mechanisms by which stressed cells choose between senescence, quiescence, or cell death. The influence of aging on this process and potential vulnerabilities of senescent cells to cell death pathways or reversal to quiescence as potential senolytic strategies were also explored. This workshop evaluated the status of the field, defined future directions, evaluated critical needs, and outlined opportunities and priorities to better understand the general mechanisms of aging biology.

Agenda

All times are in Eastern Daylight Time.

Tuesday, April 23

10:00 a.m. Welcome, Darren J. Baker, Ph.D., Mayo Clinic, Andras Orosz, Ph.D., Division of Aging Biology, National Institute on Aging and Max Guo, Ph.D., Division of Aging Biology, National Institute on Aging

10:05 a.m. Opening Remarks, Stacy Carrington-Lawrence, Ph.D., Acting Director, Division of Aging Biology, National Institute on Aging

10:10 a.m. Charge for the Workshop, Darren J. Baker, Ph.D., Mayo Clinic

10:30 a.m. Session I | Cellular Quiescence

  • Quiescence and senescence as graded states of cell-cycle withdrawal, Sabrina L. Spencer, Ph.D., University of Colorado
  • The UPR-ER and autophagy are gatekeepers of successful quiescence, Andrew Dillin, Ph.D., University of California, Berkeley
  • DNA damage and mutagenesis in quiescent yeast, Mary Ann Osley, Ph.D., University of New Mexico Comprehensive Cancer Center
  • Quiescence to senescence transition in primary oocytes and its role in the onset of ovarian aging, Lei Lei, Ph.D., University of Missouri School of Medicine

11:50 a.m. Session I Discussion

12:20 p.m. Lunch Break

1:00 p.m. Session II | Cellular Senescence

  • Senescent cells promote pathology and death, Darren J. Baker, Ph.D., Mayo Clinic
  • Mitochondria and cell senescence: a matter of life and death, Joao Passos, Ph.D., Mayo Clinic
  • Senescence in tissue repair and homeostasis, Jennifer H. Elisseeff, Ph.D., Johns Hopkins University
  • A paradoxical role for Cyclin D1 oncogene in senescence and aging, Peter D. Adams, Ph.D., Sanford Burnham Prebys

2:20 p.m. Panel Discussion

2:50 p.m. Break

3:00 p.m. Session III | Cell Death

  • Mitochondrial-driven inflammation in cancer and aging, Stephen Tait, D.Phil., University of Glasgow
  • Interactions between senescence and cell death in lung vasculature,Patty J. Lee, M.D., Mount Sinai
  • How do cells ‘decide’ to die?, Doug R. Green, Ph.D., St. Jude Children’s Research Hospital
  • Molecular determinants of senescence versus cell death in a cell under stress, Richard N. Kitsis, M.D., Albert Einstein College of Medicine

4:20 p.m. Panel Discussion

Contact Information

Please contact Andras Orosz at orosza@mail.nih.gov for questions you have about the workshop.