Rodent Resources
Notice: The NIA has long provided biological resources to the research community to facilitate research on the biology of aging. As of January 1, 2014, the NIA will no longer charge users for the biological resources, nor any related shipping fees due to a new interpretation of the regulations that govern contracting.
Miscellaneous Shipping Information
Overseas Shipping (NIH grant recipients only)
The maximum age for shipping F344 rats overseas is 26 months. The maximum age for shipping F344 x BN rats overseas is 36 months. There is a 2- to 3-week turnaround time from order placement to delivery.
Packing
Animals are packed one age group per crate.
| Animal Type | Maximum Number per Crate |
|---|---|
| Rats | 4 male 3mo and younger, 3 male older than 4mo & 6 female |
| Mice | 12 for regular aging colony, 3 for CR colony |
| BALB/c Mice | 5 (compartmentalized) |
Cagemates
C57BL/6 animals are always shipped as cagemates. Other strains are not shipped as cagemates, unless specifically requested by customer on the NIA order form.
Air Delivery Customers
All air deliveries are shipped on Monday for Tuesday/Wednesday delivery. Animals must originate from the same barrier; barriers cannot be split.
Water Kits vs. Gel Packs
Both the water kit and gel pack are safe and effective. However:
- Gel packs have more stability
- Gel packs can leak and adhere to the bedding and the animals' hair
- Water packs may damage the box if the water kit valve is broken
Miscellaneous Health Information
Tumors
Tumors are considered normal in rodents aged 16 months and older.
Surgeries
There is a 2- to 3-week turnaround time from order placement to delivery for orders involving surgery.
Age of Maturity
Regarding age and reproductive function, F344 males and females reach their sexual maturity at approximately 7 weeks of age.
General Information
Animal Replacement
For animal replacement, the Office of Biological Resources and Resource Development (OBRRD) must be notified within 48 hours of delivery. OBRRD will provide replacement animals under the following conditions:
- If animals are "dead on arrival"
- If animals die within 48 hours of arrival
- If the incorrect animal type is delivered
Age of Replacement Animals
Animals will be replaced at the same age as the original order, unless the customer specifically indicates the same DOB.
Vendor Location for Animal Research Papers
The vendor, NIA at Harlan Sprague Dawley, or Charles River Laboratories, or Taconic Farms.
Orders for Collaborators
NIA grant recipients may order animals to be delivered to collaborators; however, the animals must be billed to the grant recipient.
Inclement Weather Policy
NIA will not make any shipments when the atmospheric temperature and/or the temperature within the transportation carrier are harmful to the shipment.
Small Business Innovation Research (SBIR) Grant Recipients
SBIR grant recipients are permitted to order if they are funded by NIA.
Miscellaneous Animal Information
| Rat Strain | Color |
|---|---|
| F344 | White Albino |
| F344 x BN | *Brownish-Black |
| BN | Brown |
*Includes white area on chest and underbelly.
| Mouse Strain | Color |
|---|---|
| BALB/c | White Albino |
| C57BL/6 | Intense Black |
| CB6F1 | Agouti (brownish-gray) |
Weight of Animals
Customers are permitted to specify a weight range, but they are not permitted to request a specific weight.
Information Regarding DOB
NIA only can provide dates in a "month/year" format because the contractor weans several litters born in the same week at the same time and randomly assigns them to cages. Animals in the same cage do not have the same actual day of birth. NIA does not require the contractor to record the specific day of birth on the aging cage cards, only the month of birth.
Housing
If any animals die, no additional animals are added to their cage. Animals in the CR colonies are individually housed.
Tissue Bank Resources
Tumor Tissue Identification
To indicate tumor tissue, vials have a red top, and larger vials are marked with a red "dot".
Vital Statistics Sheet
The Vital Statistics Sheet lists all information, including tumors.
Sample Numbers
| Vial Size | Number of Samples | Comments |
|---|---|---|
| Small | 200 | Most mouse tissue is in small vials. |
| Large | 25 | Includes some rat tissue and larger mouse organs. |
DAB