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The Interventions Testing Program (ITP) is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice. Investigators at any university, institute, company, or other organization are invited to recommend interventions for testing by submitting an application before the February deadline each year. Testing is carried out in the genetically heterogeneous UM-HET3 mouse stock at three sites — the Jackson Laboratory, the University of Michigan, and the University of Texas Health Science Center at San Antonio. Those whose proposed interventions are accepted for testing by the ITP (“sponsors”) will collaborate with the ITP principal investigators to develop the test protocol and interpret the data and will be asked to serve as coauthors on resulting publications. All data will be made freely available to sponsors for use in their grant applications, research talks, etc.
For more information, see About the ITP .
Application Instructions
The submission deadline occurs once per year on the last weekday in February.
The next deadline is Friday, Feb. 27, 2026.
See Application Instructions and use the
Supported Interventions
The ITP supports the testing of up to six interventions per year.
See Supported Interventions , Publications , and the ITP Data Coordinating Center (DCC) database for information and data on all compounds tested by the ITP since 2004.
Intervention Biospecimen Repository
Plasma and fixed and frozen tissues collected from select ITP mice at 22 months of age and at the end of life are available to investigators free of charge through the ITP Intervention Biospecimen Repository (IBR) .
For a list of available tissues and instructions for requesting tissue, please visit the IBR .
Contact Information
For questions about the ITP or IBR, see the FAQs or contact Dr. Jennifer Fox .
To explore ideas about potential candidates for testing, please contact one of the ITP principal investigators:
Looking for program officials? Use the Matchmaker tool in the NIH RePORTER to easily find staff associated with specific projects or types of research. Enter abstracts, research bios, or other scientific text, and explore a list of similar projects and program officials from the RePORTER.
DAB