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Dates
Sept. 26, 2024 | 9:00 a.m. – 5:30 p.m. ET
Sept. 27, 2024 | 8:30 a.m. – 4:30 p.m. ET
Location
This is a hybrid workshop. Participants can attend virtually via Zoom, or in-person:
Rockledge Building, Room 160,
6701 Rockledge Drive,
Bethesda, MD
Purpose and Background
On Sept. 26-27, 2024, the Division of Geriatrics and Clinical Gerontology (DGCG) at the National Institute on Aging (NIA) will host a hybrid workshop along with the Division of Aging Biology (DAB) on "Relationships Between Specific Aging Mechanisms and Specific Common Human Aging Conditions.”
The identification and study of various aging-related mechanisms has opened opportunities to define the relationships between specific aging mechanisms and the etiology and progression of human aging conditions. Different technological advances have led to the development of assays for these mechanisms which can be applied to human samples to identify the role these mechanisms play in the development of various aging conditions. This workshop aims to examine how such mechanisms as mitochondrial dysfunction, autophagy and impaired proteostasis, for example, contribute to different conditions including sarcopenia, lung fibrosis and chronic kidney disease among others. The challenge rests in the elucidation of these interactions at critical stages of disease progression and in defining the questions that can be addressed using resources that are available.
The goals of the workshop are to assess the status of the field, to define critical research goals, and to prioritize future opportunities that will allow for the identification of the role of particular aging-related mechanisms in the initiation and progression of human aging-related conditions. Clarifying the specific relationship between various mechanisms of aging and the development of aging conditions will better support the development of novel therapeutics to treat these conditions. Invited speakers from disease-focused fields and aging research will present studies related to the role of specific aging-related mechanisms and pathways contributing to progression of disease for specific human age-related conditions. Discussion sessions will focus on study designs using a range of available assays that can be utilized to assess various mechanisms of aging as well as research resources such as longitudinal cohorts and disease-based cohorts/biorepositories that could be leveraged in future projects.
Registration
Please register in advance for this webinar.
Agenda
All times are in Eastern Daylight Time.
Day 1 | Thursday, September 26
9:00 a.m. Welcome and Goals of Workshop, NIA Staff
Evan Hadley, NIA
NIA staff to present background on aging related mechanisms that have been identified in etiology of specific aging-related conditions.
Session 1 | Role of Aging-Related Mechanisms in Cardiovascular Diseases
Moderator: Luigi Ferrucci, NIA
9:30 a.m. Role of Mitophagy in Peripheral Artery Disease in Humans, Luigi Ferrucci, NIA
10:00 a.m. Clonal Hematopoiesis and Cardiovascular Disease, Alexander Bick, Vanderbilt University
10:30 a.m. Mitochondrial Dysfunction, Inflammaging and Blood Pressure Variability, Laure Rouch, Tolouse, France
11:00 a.m. Break
11:15 a.m. Developing Novel Senolytics for Clinical Trials; Benefits of Repurposing Drugs, Anthony Donato, University of Utah
11:45 a.m. Mitochondrial Genetic Variation and Aging-related Diseases, Dan Arking, Johns Hopkins University
12:15 p.m. Lunch Break and Discussion Session I
Session II | Role of Aging-Related Mechanisms in Chronic Kidney Disease
Moderator: Eric Brunskill, NIDDK
1:00 p.m. Somatic Mosaicism in Kidney Disease Progression, Parker Wilson, University of Pennsylvania
1:30 p.m. The Intersection of Aging and Kidney Disease, Stuart Shankland, University of Washington
2:00 p.m. Multiomic Analysis of Human Kidney Aging, Katalin Susztak, University of Pennsylvania
2:30 p.m. Break
2:45 p.m. An Atlas of Healthy and Injured Cell States and Niches in the Human Kidney, Sanjay Jain, Washington University
3:15 p.m. Session II Discussion and General Discussion
Session III | Interactions of Mechanisms in Age-Related Conditions
4:00 p.m. Integrating subcellular and phenotypic aging through Brain Energy Conservation (BEC), Martin Piccard, Columbia University
4:30 p.m. Session III Discussion and General Discussion
5:30 p.m. Adjourn
Day 2 | Friday, September 27
Session IV | Role of Aging-Related Mechanisms in Lung Disease
Moderator: Hongwei Gao, NIA
8:30 a.m. Update on Mapping and Repository Resources and Technologies for Study of Human Lung Aging, Gloria Pryhuber, University of Rochester
9:00 a.m. Age-related failure of lung repair after pneumonia drives persistent inflammation, Scott Budinger, Northwestern
9:30 a.m. Harnessing single cell technologies to understand lung aging and aging related lung disease, Naftali Kaminski, Yale
10:00 a.m. Metabolic Reprogramming and Drug Repurposing for Fibrotic Lung Disease, Victor Thannickal, Tulane
10:30 a.m. Session IV Discussion
Session V | Role of Aging-Related Mechanisms in Musculoskeletal Disease
Moderator: Chhanda Dutta, NIA
11:30 a.m. Emerging concepts of mitochondrial involvement in aging skeletal muscle, Russ Hepple, University of Florida
12:00 p.m. Role of Skeletal Muscle Dysfunction in Patients with Heart Failure with Preserved Ejection Fraction, Payman Zamani, University of Pennsylvania
12:30 p.m. Mitochondrial Bioenergetics and Healthy Longevity, Anthony Molina, UCSD
1:00 p.m. Dysfunction in Mitochondria and Autophagy in Joint Aging and Osteoarthritis, Martin Lotz, Scripps Institute
1:30 p.m. Session V Discussion and Lunch Break
Session VI | Development and Validation of Assays for Aging Mechanisms for Conditions of Aging Conducted in Clinical Samples
Moderators: Rebecca Fuldner and Chhanda Dutta, NIA
2:30 p.m. Panel Discussions
- Resources Available for Future Studies, Rebecca Fuldner, NIA
- Development of Assays to Assess Aging Related Mechanisms, Tamar Tchkonia, Ph.D., Cedars Sinai
- Proteostasis and aging, ideas for biomarkers, Claudio Hetz, Buck Institute
- Development of Assays to Measure Mitochondial Function, Russ Hepple, University of Florida
- Development of Assays to Measure Senescent Cell Burden, Birgit Schilling, Ph.D., Buck Institute
4:30 p.m. Adjourn
Contact Information
Please contact Rebecca A. Fuldner at rebecca.fuldner@nih.gov questions you may have about the workshop.
Reasonable Accommodations: If you need reasonable accommodation to participate in this event, please contact the meeting organizer listed under Contact information. Please make your request no later than 1 week before the event.