Vitamin D Deficiency in Adults: Screening

1. Determining the cut point that defines vitamin D deficiency, the sensitivity and specificity of various assays using an internationally accepted reference standard, and whether total serum 25-(OH)D is the best measure of vitamin D deficiency in all populations.
2. Effects of acute inflammation on vitamin D levels.
3. Which treatment regimens may benefit specific vitamin D–deficient populations, such as men and non-Caucasian ethnic groups, who are absent from the evidence base.
4. Studies (in addition to the VITAL trial) to evaluate the harms of screening for and treating vitamin D deficiency.

The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for vitamin D deficiency in asymptomatic adults.

Vitamin D Deficiency in Adults: Screening Read full statement 1