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Celiac Disease: Screening

Studies that randomly assign participants at increased risk for celiac disease to screening vs. non screening and evaluate clinical outcomes.
Accuracy of serologic testing in asymptomatic persons, especially those with disease risk factors.
Natural history of positive serology in patients without histologic changes or with histologic confirmation but no symptoms.
Treatment studies in screen-detected, asymptomatic persons to understand the effects of adherence to a gluten-free diet, as well as the effects of immediate vs. delayed dietary changes.
Treatment studies should report results stratified according to baseline histologic findings, given current uncertainty about the natural history of celiac disease in persons with mild histologic abnormalities.

The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for celiac disease in asymptomatic persons.

Celiac Disease: Screening Read full statement 1