Tobacco Regulatory Science Program | ODP

Funding Opportunities

• RFA-OD-25-008 : Tobacco Regulatory Science Small Grant Program for New Investigators (R03 Clinical Trial Optional). FAQs about the opportunity are now available.

Notices

• NOT-OD-24-172 : Notice of Early Expiration of the Tobacco Regulatory Science K Notice of Funding Opportunity Announcements
• NOT-OD-25-001 : Notice of Early Expiration of RFA-OD-23-017 "Tobacco Regulatory Science (R01 Clinical Trial Optional)"

FDA Proposes Reducing Nicotine to Minimally or Nonaddictive Level in Cigarettes and Certain Other Tobacco Products

On January 15, 2025, FDA issued a proposed rule that, if finalized, would make cigarettes and certain other combusted tobacco products minimally or nonaddictive by limiting the level of nicotine in those products. The FDA is proposing to cap the nicotine level at 0.7 milligrams per gram of tobacco in cigarettes and certain other combusted tobacco products, which is significantly lower than the average concentration in these products on the market today. Based on the scientific evidence outlined in the proposed rule, the proposed nicotine level would be low enough to no longer create or sustain addiction. Importantly, a large body of research also shows reduced nicotine content cigarettes do not lead smokers to compensate for lower nicotine by smoking more. The agency intends to seek input on the proposal, including through a public comment period that will be open January 16 through September 15, 2025.