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Position Type: Postdoctoral Position at the NIH Position Title: Postdoctoral Position in Stem Cells, Epigenetics, Aging Interventions
Position Overview: The Epigenetics and Stem Cell Aging Unit (ESCU) within the Translational Gerontology Branch (TGB) at the NIA is at the forefront of groundbreaking research to restore function to aging tissues. By studying stem cell aging, we are working to develop therapies that can extend healthy lifespan and improve quality of life by defining and resetting alterations in the stem cells to restore function to the systems they regulate during aging.
Research Focus: We are seeking an enthusiastic postdoctoral fellow to join our collaborative lab environment to pursue the understanding of mechanisms that drive stem cell functional loss, especially those associated with aging. Our team uses intervention studies to mitigate these aging changes and is working to understand how aging interventions such as caloric restriction, NAD+ supplementation, and reprogramming affect epigenetics, transcription, translation, and functional properties of adult stem cells.
Responsibilities:
Conducting experimental research to manipulate adult stem cells to mitigate stem cell aging phenotypes.
Utilizing high-throughput genomic techniques (e.g., RNA sequencing, single-cell sequencing, CUT&RUN or CUT&Tag, 3D, chromosome conformation capture) to establish if manipulation resets age-associated changes in epigenetic and transcriptional profiles and restores functional potential.
Employing animal models and clinical samples as experimental paradigms
Collaborating with team members to interpret data, generate hypotheses, and design follow-up experiments.
Contributing to the publication of research findings in peer-reviewed journals and presenting results at conferences and seminars.
Qualifications: Candidates should have a Ph.D. degree or equivalent in biomedicine, biochemistry, genetics, or immunology with less than five years postdoctoral training, and one or more first-author peer-reviewed academic paper(s) in molecular biology, stem cell biology, or epigenetics. Candidates may be U.S. citizens, permanent residents, or foreign nationals. Salary will be commensurate with research experience according to the NIH intramural pay scale. Successful applicants will have: Strong background in genomics, epigenetics, and / or molecular biology Experience with high-throughput genomic techniques and data analysis. Openness to working with animal models, primary cells, and patient samples Flow cytometry experience is desirable but not essential. Ability to work both independently and collaboratively in a multidisciplinary research environment. Excellent communication skills and a track record of scientific productivity (publications, conference presentations).
Application Process: Interested candidates should submit a cover letter describing their research interests and career goals, a current CV with a list of publications, and three letters of reference Dr. Isabel Beerman (isabel.beerman@nih.gov). Review of applications will begin immediately and continue until the position is filled.
Employer Name: National Institutes of Health, National Institute on Aging, Translational Gerontology Branch Location: Baltimore, MD, Biomedical Research Center (BRC)
Disclaimer: The NIH is dedicated to building a diverse community in its training and employment programs.