Skin and Cutaneous Wound Healing Workshop

Elderly woman check the appearance of her nick wrinkles in a handheld mirror.

Audience

Researchers and clinicians at all career stages who are interested in age-associated biological changes that take place in skin and their clinical impact.

Dates

April 22, 2024 | 9:00 a.m. – 4:40 p.m. ET

Purpose and Background

The Division of Aging Biology (DAB) at NIA hosted this one-day virtual workshop on the topic of skin and cutaneous wound healing in the context of aging. Skin is a first line of defense from external insults such as UV, pollution, chemicals, and harmful microbes. However, age-associated changes in the skin weakens this defense and predisposes the older population to increased skin conditions, infections, trauma, chronic wounds, and skin cancer. The purpose of this workshop was to bring together experts on skin aging to understand known and potential relationships among age-related changes in the skin microstructure, barrier function and cellular responses to wound healing to improve overall skin health as well wound care.

Agenda

Monday, April 22

9:00 a.m. Welcome, Introduction and Goals of the Workshop, Pragati Katiyar, Ph.D., Program Officer, Aging Physiology Branch, Division of Aging Biology, National Institute on Aging and Amanda Boyce, Ph.D., Chief, Aging Physiology Branch, Division of Aging Biology, National Institute on Aging

9:15 a.m. Keynote Presentation – Understanding Aging in Wound Healing: A Significant Knowledge Gap and a Major Clinical Need, Marjana Tomic-Canic, Ph.D., University of Miami

10:00 a.m. Break

10:15 a.m. Session I | Mechanisms of Delayed Wound Healing in Aging Skin
Moderator: Geoffrey C. Gurtner, M.D., FACS, University of Arizona

  • Defective Wound Healing, Age, and Skin Stem Cells, George F. Murphy, M.D., Harvard Medical School
  • Hypoxia Signaling and Aging, Geoffrey C. Gurtner, M.D., FACS, University of Arizona
  • Using Multi-Omics to Understand Skin Homeostasis, Cristina De Guzman Strong, Ph.D., Henry Ford Health, Michigan State University
  • Panel Discussion

12:00 p.m. Lunch

12:30 p.m. Session II | Effect of Microbiome on Aging Skin
Moderator: Julie Segre, Ph.D., National Human Genome Research Institute, NIH

  • Age, Frailty, and Infection Risk Reservoirs: The Skin Microbiome of Older Adults, Julia Oh, Ph.D., The Jackson Laboratory
  • Human Skin as a Reservoir for Candida Auris and ESKAPE Pathogens: Transmissible Microbes and Antibiotic Resistance in Nursing Homes, Julie Segre, Ph.D., National Human Genome Research Institute, NIH
  • Microbiome-Based Biomarkers of Wound Healing, Lindsay R. Kalan, Ph.D., University of Wisconsin
  • Panel Discussion

2:15 p.m. Break

2:30 p.m. Session III | Role of Sensory Immunology in Skin Aging
Moderator: David Owens, Ph.D., Columbia University

  • Emerging Directions using Tissue Engineered Skin Models, David Kaplan, Ph.D., Tufts University
  • Aging-related Dysregulation of the Touch Dome Mechanosensory Niche, David Owens, Ph.D., Columbia University
  • The Role of the Dermal Extracellular Matrix in Skin Aging, Gary Fisher, Ph.D., University of Michigan
  • Panel Discussion

4:15 p.m. Workshop Prospect and Wrap-Up
Moderator: Geoffrey C. Gurtner, M.D., FACS, University of Arizona

  • Conclusion of the Workshop, Geoffrey C. Gurtner, M.D., FACS, University of Arizona
  • Final Remarks from NIA-DAB Leadership, Stacy Carrington-Lawrence, Ph.D., Acting Division Director, Division of Aging Biology, National Institute on Aging

Contact Information

Please contact Pragati Katiyar at pragati.katiyar@nih.gov for questions you have about the workshop.