MED-LATE: Understanding mechanisms and relationships to other diseases

AD-Related Dementias Focus

Study the intersection of hippocampal sclerosis (HS) and LATE-NC, within and across all disciplines (clinical, pathologic, diagnostic, genetic, molecular, etc.) and consider the roles of vasculopathy, senescence, and other potential contributing factors, assuring diversity, inclusion, and equity.

2029 PAR-23-211: Mechanistic Investigations into ADRD Multiple Etiology Dementias (R01 - Clinical Trial Not Allowed) PAR-23-212: Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD & other ADRDs (R01 - Clinical Trial Not Allowed) PAR-24-147: Mechanistic Investigations into ADRD Multiple Etiology Dementias (R01 - Clinical Trial Not Allowed) PAR-24-148: Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD and other ADRDs (R01 - Clinical Trial Not Allowed) 2.BB In Progress TDP-43 in AD/ADRD: Understanding mechanisms and relationships to other diseases DN 2022 ADRD Summit: Multiple Etiology Dementias (MED) Special Topic: LATE (TDP-43 in Common Late Onset Dementias) Milestone 4, Priority 4 Workshop: LATE 2022 Workshop: Gaps and Opportunities Related to Clinical Detection of Limbic-predominant Age-related TDP-43 Encephalopathy (LATE) Research on Disease Mechanisms

• At least four studies to identify molecular, genetic, clinical, and pathologic drivers of LATE-NC with hippocampal sclerosis, versus, LATE-NC without hippocampal sclerosis; studies are to be powered to understand relevant similarities and potential mechanistic differences in at least two populations that experience health disparities.