MED-LATE: Differential diagnosis

AD-Related Dementias Focus

Define LATE (pathologic, clinical, genetic, molecular) classification and diagnostic boundaries across FTLD-TDP, AD and other dementia related pathologies and their syndromes to enhance diagnosis, research, and awareness assuring diversity, inclusion, and equity.

2029 PAR-23-211: Mechanistic Investigations into ADRD Multiple Etiology Dementias (R01 - Clinical Trial Not Allowed) PAR-23-212: Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD & other ADRDs (R01 - Clinical Trial Not Allowed) PAR-24-148: Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD and other ADRDs (R01 - Clinical Trial Not Allowed) 11.M In Progress TDP-43 in AD/ADRD: Differential diagnosis DN 2022 ADRD Summit: Multiple Etiology Dementias (MED) Special Topic: LATE (TDP-43 in Common Late Onset Dementias) Milestone 1, Priority 1 Workshop: LATE 2022 Workshop: Gaps and Opportunities Related to Clinical Detection of Limbic-predominant Age-related TDP-43 Encephalopathy (LATE) Enabling Technologies and Disease Monitoring

• Develop and publish a report that defines limbic-predominant age-related TDP-43 encephalopathy (LATE) classification and diagnostic boundaries (pathologic, clinical, genetic, molecular) across FTD, AD and other dementia diagnoses, other nervous system disorders with TDP-43 proteinopathies, and in diverse populations.