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AD-Related Dementias Focus
Enhance and standardize the techniques for neuropathologic characterization of LBD and the use of LBD pathology cohorts including more diverse cohorts.
2027 RFA-NS-17-016: Leveraging Existing Resources for Research on Lewy Body Dementia (R03) RFA-NS-18-015: Structural Biology of Alzheimer's Disease Related Dementias (ADRDs) Proteinopathies (U01) RFA-NS-19-013: Lewy Body Dementia Center Without Walls (CWOW) (U54) PAS-19-210: Progression Markers for Cognitive Impairment in Parkinson's Disease Dementia (R01) PAR-19-170: Progression Markers for Cognitive Impairment in Parkinson's Disease Dementia (R01) RFA-NS-20-014: Peripheral Pathology in the Lewy Body Dementias NOT-NS-21-001: Notice of Special Interest: Administrative Supplements for Connecting Pre-mortem Clinical Information with Post-Mortem Brain Analysis NOT-NS-21-001: Administrative Supplements for Connecting Pre-mortem Clinical Information with Post-Mortem Brain Analysis RFA-NS-22-062: Connecting Machine Readable Digital Human AD/ADRD Neuropathological Library Platforms for Advanced Analytics (U24 Clinical Trial Not Allowed) 1.K In Progress Characterize nervous system changes in LBD cohorts that have come to autopsy to identify disease-specific underlying mechanisms to guide biomarker and therapeutic approaches. 2016 ADRD Summit: Lewy Body Dementias (LBD) Focus Area 2: Discover Disease Mechanisms Through Brain Mapping and Genetics, Recommendation 3 (PDF, 901K) 2022 ADRD Summit: Lewy Body Dementias (LBD) Milestone 6, Priority 2 Workshop: Imaging the Future of In vivo Neuropathological Diagnosis through Postmortem Analyses Brain Donation: A Gift for Future Generations Brain Donation Resources for ADRCs Workshop: Dementia with Lewy Bodies: Filling the Gaps in Translational and Clinical Research Population Studies and Precision Medicine NIH NeuroBioBank Parkinson’s Disease Biomarkers Program Consortium Meeting NINDS PDBP Data Management Resource (DMR) International Lewy Body Dementia Conference Projects funded in FY22 NACC Biospecimen Locator
- Optimize, standardize, and disseminate best practices for clinical data collection, donation, sampling, preparation, storage and distribution of post-mortem LBD tissue, including specific emphasis and guidance for best practices relevant to diverse populations.
- At least one project or effort to increase donation and post-mortem clinical data on subjects who are at-risk for LBD and who are from diverse populations.
Summary of Key Accomplishments
NINDS and NIA continue to support the NIH NeuroBioBank and the Alzheimer's Disease Centers, which make brain tissue from hundreds of individuals with a pathological diagnosis of LBD available for sharing with researchers. Much of this brain tissue is associated with extensive clinical and neuroimaging information obtained when the individual was alive. NIH intramural staff initiated a collaboration with 17 European and 27 North American sites/consortia to collect brain tissue for genetic sequencing from 1789 individuals with LBD, resulting in the identification of important risk factors. An international effort to propose criteria and best practices for the evaluation of LBD pathology that included NIA/NINDS-funded researchers was published in 2021.
The key accomplishments summary is current as of July 2022.