Non-Pharmacological Interventions: Combined pharmacological and lifestyle interventions

Support studies that employ data-driven approaches to robustly test the efficacy of multi-modal interventions that combine pharmacological and lifestyle interventions.

2035 8.C To Be Initiated Support studies that employ data-driven approaches to robustly test the efficacy of multi-modal interventions... DN 2012 AD Summit: 5B, 5C, 5D, and 5F 2017 Dementia Care Summit: 4.2 2018 AD Summit: 5H and 5I Workshop: Precision Medicine Approaches for Developing Combination Therapies for the Treatment and Prevention of Alzheimer's Disease (AD) and AD-Related Dementias Workshop: NASEM Research Priorities for Preventing and Treating Alzheimer’s Disease and Related Dementias Non-Pharmacological Interventions 2023

Initiate clinical trials for at least 3 interventions combining pharmacological and non-pharmacological interventions for AD and ADRD treatment or prevention. These trials should incorporate digital health devices and deep, longitudinal molecular phenotyping to:

• track person-specific trajectories of treatment response.
• understand the therapeutic mechanism of action.
• enable comprehensive success/failure analysis.

Ensure inclusion of diverse populations in studies.