Addressing the Challenges to Successful Recruitment and Retention in Alzheimer's Disease Clinical Trials

Among the key challenges in Alzheimer's disease drug development is the timely completion of clinical trials. Unfortunately, clinical trials often suffer from slow or insufficient enrollment. Successful clinical trial recruitment describes a balance between expeditiously achieving full enrollment and ensuring an appropriate study sample. Investigators face a number of challenges to the successful negotiation of this balance. The failure to address these challenges means that drug development may take more time and money and that trial results may not adequately represent drug efficacy or may not be applicable beyond the study. This article reviews the challenges to recruitment and retention in Alzheimer’s disease clinical trials and presentsa framework to address them.

Grill JD, Karlawish J. Addressing the challenges to successful recruitment and retention in Alzheimer's disease clinical trials . Alzheimer's Research and Therapy 2010;2(6):34.

ab81ff4b848b284db1910b18fd95c067 Recruit & Retain Participants 2019-01-14T00:00:00Z Barriers & Facilitators Research Articles