Laboratory of Genetics & Genomics

Myriam Gorospe , Ph.D., Chief
David Schlessinger, Ph.D., NIH Distinguished Investigator

The mission of the Laboratory of Genetics and Genomics (LGG) is to understand the genetic and genomic changes across the life span that influence aging traits. The Laboratory investigates the genes and gene expression programs that govern the physiologic decline of aging, including reduced muscle strength, decreased ability to regenerate tissues and organs, and impaired responses to stress conditions. The Laboratory also studies the genetic and genomic basis of chronic pathologies that increase with age, such as diabetes, arthritis, obesity, neurodegeneration, cardiovascular disease, and cancer. Additionally, it explores intervention strategies, including natural compounds, to combat age-associated chronic pathologies.