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The zebrafish guide to tuberculosis

6a4009913f063566606d426733b01580 University of Cambridge {"start": "2015-10-07T19:00:00", "end": "2015-10-07T20:00:00"} lr404@cam.ac.uk

Ramakrishnan, Lalita, Ph.D. Professor of Immunology and Infectious Diseases Wellcome Trust Principal Research Fellow

We have developed the zebrafish as a surrogate model to study human tuberculosis. The optical transparency combined with the genetic tractability of this model have proved to be powerful and have allowed us to make surprising discoveries about tuberculosis pathogenesis, immunity, and drug tolerance that suggest completely new approaches to treatment. These discoveries and their application to human tuberculosis treatment will be discussed.

https://videocast.nih.gov/watch=17256 http://www.med.cam.ac.uk/ramakrishnan/