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The Laboratory of Muscle Stem Cells & Gene Regulation investigates the epigenetics and metabolic changes in muscle stem cells, muscle-resident cells, and myofibers in adulthood and aging.
Our ultimate goal is to develop dietary and pharmacological interventions that target chromatin, transcriptional, and metabolic pathways in skeletal muscle cells. These interventions are designed to enhance muscle regeneration in muscular dystrophies and support the maintenance of muscle homeostasis and repair throughout adulthood and aging.
Areas of Interest
Specific areas of interest include:
- Transcriptional control of the regulatory circuits involved in various aspects of adult and aging muscle stem cell biology.
- The functional relationship between metabolites and epigenetic modifications impacting adult and aging muscle stem cell biology.
- The role of non-coding RNAs in skeletal muscle biology.
Related NIAMS Labs
Scientific Advances
- Morgan McKenzie, MD/PhD student, University of Colorado Anschutz
- Anthony Ascoli, MD,Resident Physician, PennMedicine, Philadephia, PA
- Giuseppina Caretti, PhD,Associate Professor, Department of Genetics, University of Milan, Italy
- Daphney Clermont, MD MPH,Pediatrician,The Johns Hopkins Hospital, MD
- Antonio Costanzo, MD, Head and Professor, Dermatology Clinical Unit, Humanitas University, Milan, Italy
- Veronica Ciuffoli, PhD,Research Scientist, Stanford University
- Stefania Dell’Orso, PhD,Staff Scientist, Director Office of Science and Technology, NIAMS
- Assia Derfoul, PhD,Biologist, Muscle Disease Unit, LMSCGR, NIAMS-IRP
- Monica Di Padova, PhD,Assistant Professor, Department of Experimental Medicine, University of L’Aquila, Italy
- Gabriella Fiore, PhD,Research Associate, Comparative Genomic Center, James Cook University, Townsville, Australia
- Marcella Fulco, MD, PhD,career transitionto biomedical patenting
- Shanil Haugen, PhD,Assistant Director,US Food and Drug Administration
- Simona Iezzi, PhD,Staff Scientist, Regina Elena Cancer Center, Rome, Italy
- Aster Juan, PhD,Scientific Review Officer, CSR, NIH
- Mamduh Khateb, PhD,Research Fellow, NCI
- Raj Letchuman,Undergraduate Student, Yale University
- Christopher Lopez, MD/PhD Student, Stanford University
- Frederic Lluis Vinas, PhD, Professor, Stamcelinstituut Leuven (SCIL), KU Leuven, Leuven, Belgium
- Aissa Kaba, MTM, MedTech Scholar, UC Berkeley&UCSF
- Miroslav Koulnis, PhD,Scientist, Sony Biotechnology, Boston, MA
- Joseph G. Marx, PhD,F.B.I. Employee
- Kambiz Mousavi, PhD,Senior Scientist, Moderna Therapeutics, Cambridge, MA
- Alessandra Pasut, PhD,Postdoctoral Fellow, Center for Cancer Biology, Leuven, Belgium
- Jelena Perovanovic, PhD,Computational Biologist, Recursion, Salt Lake City, UT
- Valentina Proserpio, PhD, Department of Life Sciences and Systems Biology, University of Turin
- Madison Quig, BS, Graduate Student,University of Oxford, UK.
- Giulia Riparini, PhD,Senior Scientist, AstraZeneca
- James G. Ryall, PhD,Chief Scientific Officer, Vow Food, Sydney, Australia
- Kayoko Saso, PhD,Pharmacist
- R. Louis Schiltz, PhD,Biologist, Laboratory of Receptor Biology and Gene Expression, NCI
- Pei-Fang Tsai, Ph.D.Principal Scientist, Fate Therapeutics, San Diego, CA
- Karinna Vivanco,Graduate Student,UC Berkeley/UCSF Bioengineering PhD Program
- Stan Wang, MD PhD,CEO & Founder, Thymmune Therapeutics, Non-Resident Senior Fellow Council of Strategic Risks
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Transcriptomics, regulatory syntax, and enhancer identification in mesoderm-induced ESCs at single-cell resolution.
Khateb M, Perovanovic J, Ko KD, Jiang K, Feng X, Acevedo-Luna N, Chal J, Ciuffoli V, Genzor P, Simone J, Haase AD, Pourquié O, Dell'Orso S, Sartorelli V
Cell Rep.
2022 Aug 16;
40(7).
doi: 10.1016/j.celrep.2022.111219
PMID: 35977485
Single cell analysis of adult mouse skeletal muscle stem cells in homeostatic and regenerative conditions.
Dell'Orso S, Juan AH, Ko KD, Naz F, Perovanovic J, Gutierrez-Cruz G, Feng X, Sartorelli V
Development.
2019 Apr 11;
146(12).
pii: dev174177. doi: 10.1242/dev.174177
PMID: 30890574
A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription In trans.
Tsai PF, Dell'Orso S, Rodriguez J, Vivanco KO, Ko KD, Jiang K, Juan AH, Sarshad AA, Vian L, Tran M, Wangsa D, Wang AH, Perovanovic J, Anastasakis D, Ralston E, Ried T, Sun HW, Hafner M, Larson DR, Sartorelli V
Mol Cell.
2018 Jul 5;
71(1).
doi: 10.1016/j.molcel.2018.06.008
PMID: 29979962
Shaping Gene Expression by Landscaping Chromatin Architecture: Lessons from a Master.
Sartorelli V, Puri PL
Mol Cell.
2018 Aug 2;
71(3).
doi: 10.1016/j.molcel.2018.04.025
PMID: 29887393
Metabolic Reprogramming of Stem Cell Epigenetics.
Ryall JG, Cliff T, Dalton S, Sartorelli V
Cell Stem Cell.
2015 Dec 3;
17(6).
doi: 10.1016/j.stem.2015.11.012
PMID: 26637942
The NAD(+)-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells.
Ryall JG, Dell'Orso S, Derfoul A, Juan A, Zare H, Feng X, Clermont D, Koulnis M, Gutierrez-Cruz G, Fulco M, Sartorelli V
Cell Stem Cell.
2015 Feb 5;
16(2).
doi: 10.1016/j.stem.2014.12.004
PMID: 25600643
eRNAs promote transcription by establishing chromatin accessibility at defined genomic loci.
Mousavi K, Zare H, Dell'orso S, Grontved L, Gutierrez-Cruz G, Derfoul A, Hager GL, Sartorelli V
Mol Cell.
2013 Sep 12;
51(5).
doi: 10.1016/j.molcel.2013.07.022
PMID: 23993744
Job Vacancy: Postdoctoral positions are immediately available in the Laboratory of Muscle Stem Cells and Gene Regulation (LMSCGR) at NIAMS at the National Institutes of Health, Bethesda, MD, USA. Ambitious and strongly motivated individuals with a solid background in molecular biology (bioinformatics is desirable but not required) are invited to apply .
