Newborn Screening by Whole Genome Sequencing Collaboratory

Initiative Snapshot

The Common Fund Venture Initiative, Newborn Screening by Whole Genome Sequencing (NBSxWGS) Collaboratory, has initiated the BRIDGES-NBS project. NBSxWGS (BRIDGES-NBS) will unite several groups around a shared goal: enhancing early diagnosis of treatable genetic conditions in newborns. The groups will assess the feasibility of incorporating whole genome sequencing (WGS) into United States public health newborn screening (NBS) programs through a collaboration of multiple state public health laboratories (PHLs). This could pave the way in providing easier access to advanced genetic screening for hundreds of treatable diseases.

This groundbreaking effort aims to keep pace with evolving therapeutic developments for rare childhood conditions, and to foster partnerships among diverse interest groups—academic institutions, sequencing centers, state public health laboratories, bioethicists, patient advocates, parents and caregivers of newborns, underserved communities, and the general public. The initiative will implement a transparent informed consent process for parents and caregivers, and an ethical, legal, and social implications (ELSI) study will examine public perceptions of WGS as part of NBS to ensure that the sequencing process and access to it are considered trustworthy. Lessons learned by members of NBSxWGS (BRIDGES-NBS) are intended to enable early identification of infants at risk for serious genetic disorders—where timely intervention can make all the difference.

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Note: This initiative was formerly named Building Evidence and Collaboration for GenOmics in Nationwide Newborn Screening.

Initiative Updates

Sign up for the NBSxWGS listserv to stay up to date on the latest news and announcements.

Have a question? Reach out to us at BRIDGES-NBS@od.nih.gov

BRIDGES-NBS Website

Find information about the project and team. Visit the Website

Funded Research Newborn Screening by Whole Genome Sequencing (NBSxWGS) Collaboratory Research Opportunity Announcement

OTA-25-004

Related Links & FAQs

Newborn Screening by Whole Genome Sequencing Collaboratory Frequently Asked Questions

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