Program Snapshot
Part of the High-Risk, High-Reward Research program , the award supports scientists with outstanding records of creativity pursuing new research directions to develop pioneering approaches to major challenges in biomedical, social science, and behavioral research.
Open to all career stages Single PI only No preliminary data required Must be new scientific research direction Minimum of 51% research effort in first 3 years 3 Letters of Reference required $700,000 in direct costs per year for up to 5 years View Current Funding Opportunities
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Award Overview
The NIH Director’s Pioneer Award (DP1 mechanism), established in 2004, supports highly innovative researchers at any career stage who propose bold research projects with unusually broad scientific impact. To be considered “pioneering,” the proposed research must reflect ideas that are substantially different from those being pursued in the investigator’s research program or elsewhere. No detailed experimental plan or detailed budget is expected, and the major component of the application is a five-page essay describing the project and its innovation and significance, the investigator’s history of being highly innovative, and why the proposed project is suitable for the award. Three letters of reference must also be provided and discuss the applicant’s scientific innovativeness and creativity.
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Webinar Funded Research 2025 NIH Director's Pioneer Award (DP1)
RFA-RM-24-002
2022 NIH Director's Pioneer Award (DP1) RFA-RM-21-015
2021 NIH Director's Pioneer Award (DP1)
RFA-RM-20-011
PI Name Institution Name Title ANIKEEVA, POLINA O MASSACHUSETTS INSTITUTE OF TECHNOLOGY Fusion of Nanomagnetic and Viral Tools to Interrogate Brain-Body Circuits CLARK, PATRICIA LOUISE UNIVERSITY OF NOTRE DAME Decoding the Regulation of Protein Folding by Synonymous Codon Usage COSTA, RUI M COLUMBIA UNIVERSITY HEALTH SCIENCES Brain Control of Internal Organ Function GACK, MICHAELA ULRIKE CLEVELAND CLINIC LERNER COM-CWRU Defining the Viral PTMome: Towards the Development of Novel Antiviral Approaches HIGLEY, MICHAEL JAMES YALE UNIVERSITY Bridging Cellular and Systems Neuroscience: Synaptic Dynamics Underlying Behavior HUANG, Z JOSH DUKE UNIVERSITY RNA-Programmable Cell-Type Targeting, Editing, and Therapy MURPHY, COLEEN TARA PRINCETON UNIVERSITY Cracking the Code of Transgenerational Inheritance of Behavior PHILLIPS-CREMINS, JENNIFER ELIZABETH UNIVERSITY OF PENNSYLVANIA From 3D Genomes to Neural Connectomes: Higher-Order Chromatin Mechanisms Encoding Long-Term Memory RICHARDS, LINDA J WASHINGTON UNIVERSITY Emergence of Activity Patterns in the Cerebral Cortex and Their Influence on Brain Circuit Development and Function SHAPIRO, MIKHAIL CALIFORNIA INSTITUTE OF TECHNOLOGY Sonogenetic Remote Control of Cellular Function
2021 NIH Director's Pioneer Award (DP1) RFA-RM-20-011
PI Name Institution Name Title ANIKEEVA, POLINA O MASSACHUSETTS INSTITUTE OF TECHNOLOGY Fusion of Nanomagnetic and Viral Tools to Interrogate Brain-Body Circuits CLARK, PATRICIA LOUISE UNIVERSITY OF NOTRE DAME Decoding the Regulation of Protein Folding by Synonymous Codon Usage COSTA, RUI M COLUMBIA UNIVERSITY HEALTH SCIENCES Brain Control of Internal Organ Function GACK, MICHAELA ULRIKE CLEVELAND CLINIC LERNER COM-CWRU Defining the Viral PTMome: Towards the Development of Novel Antiviral Approaches HIGLEY, MICHAEL JAMES YALE UNIVERSITY Bridging Cellular and Systems Neuroscience: Synaptic Dynamics Underlying Behavior HUANG, Z JOSH DUKE UNIVERSITY RNA-Programmable Cell-Type Targeting, Editing, and Therapy MURPHY, COLEEN TARA PRINCETON UNIVERSITY Cracking the Code of Transgenerational Inheritance of Behavior PHILLIPS-CREMINS, JENNIFER ELIZABETH UNIVERSITY OF PENNSYLVANIA From 3D Genomes to Neural Connectomes: Higher-Order Chromatin Mechanisms Encoding Long-Term Memory RICHARDS, LINDA J WASHINGTON UNIVERSITY Emergence of Activity Patterns in the Cerebral Cortex and Their Influence on Brain Circuit Development and Function SHAPIRO, MIKHAIL CALIFORNIA INSTITUTE OF TECHNOLOGY Sonogenetic Remote Control of Cellular Function
2020 NIH Director's Pioneer Award (DP1)
RFA-RM-19-005
PI Name Institution Name Title BARRON, ANNELISE EMILY STANFORD UNIVERSITY Role of Innate Immune Dysregulation in the Etiology of Dementia COLLINS, KATHLEEN UNIVERSITY OF CALIFORNIA BERKELEY Human Genetic Supplementation Without Donor DNA or a DNA Break HARVEY, CHRISTOPHER D HARVARD MEDICAL SCHOOL Toward Mechanistic Cognitive Neuroscience: Cell Types, Connectivity, and Patterned Perturbations KIM, PETER S STANFORD UNIVERSITY Creating High-Resolution, Epitope-Focused Vaccines LITT, BRIAN UNIVERSITY OF PENNSYLVANIA Ghost in the Machine: Melding Brain, Computer and Behavior QIAN, SHU-BING CORNELL UNIVERSITY A Genetic Circuit Formed by Ribosomes ROSENBERG, SUSAN M BAYLOR COLLEGE OF MEDICINE Harnessing Proteins as Drugs: the Protectome of Cancer- and Aging-Prevention Proteins SCHOGGINS, JOHN W UT SOUTHWESTERN MEDICAL CENTER A Functional Evolutionary Genetic Approach to Combat Viral Infection VEESLER, DAVID UNIVERSITY OF WASHINGTON Unraveling the Bat Humoral Immune Response Against Zoonotic Viruses to Guide the Design of Next-Generation Therapeutics ZERNICKA-GOETZ, MAGDALENA CALIFORNIA INSTITUTE OF TECHNOLOGY Placental Models to Support Embryogenesis In Vitro
2020 NIH Director's Pioneer Award (DP1) RFA-RM-19-005
PI Name Institution Name Title BARRON, ANNELISE EMILY STANFORD UNIVERSITY Role of Innate Immune Dysregulation in the Etiology of Dementia COLLINS, KATHLEEN UNIVERSITY OF CALIFORNIA BERKELEY Human Genetic Supplementation Without Donor DNA or a DNA Break HARVEY, CHRISTOPHER D HARVARD MEDICAL SCHOOL Toward Mechanistic Cognitive Neuroscience: Cell Types, Connectivity, and Patterned Perturbations KIM, PETER S STANFORD UNIVERSITY Creating High-Resolution, Epitope-Focused Vaccines LITT, BRIAN UNIVERSITY OF PENNSYLVANIA Ghost in the Machine: Melding Brain, Computer and Behavior QIAN, SHU-BING CORNELL UNIVERSITY A Genetic Circuit Formed by Ribosomes ROSENBERG, SUSAN M BAYLOR COLLEGE OF MEDICINE Harnessing Proteins as Drugs: the Protectome of Cancer- and Aging-Prevention Proteins SCHOGGINS, JOHN W UT SOUTHWESTERN MEDICAL CENTER A Functional Evolutionary Genetic Approach to Combat Viral Infection VEESLER, DAVID UNIVERSITY OF WASHINGTON Unraveling the Bat Humoral Immune Response Against Zoonotic Viruses to Guide the Design of Next-Generation Therapeutics ZERNICKA-GOETZ, MAGDALENA CALIFORNIA INSTITUTE OF TECHNOLOGY Placental Models to Support Embryogenesis In Vitro
2019 NIH Director's Pioneer Award (DP1)
RFA-RM-18-007
PI Name Institution Name Title ANDERMANN, MARK L BETH ISRAEL DEACONESS MEDICAL CENTER Look Inward: Brainstem and Cortical Circuits for Boosting Interoceptive Attention EBERWINE, JAMES H UNIVERSITY OF PENNSYLVANIA The Secret Lives of RNA: The In Vivo 3D-Structural Logic of Single Neuron RNA Metabolism ELISSEEFF, JENNIFER H JOHNS HOPKINS UNIVERSITY Biomaterials-Directed Regenerative Immunotherapies GRECO, VALENTINA YALE UNIVERSITY Defining the Role of Mutational Burden in Sustaining Normal Homeostasis During Aging HERMAN, CHRISTOPHE BAYLOR COLLEGE OF MEDICINE A Synthetic Platform for Non-Antibiotic Eradication of Bacterial Infections HUR, SUN BOSTON CHILDREN'S HOSPITAL Resolving Functional Aggregates: A New Perspective on Innate Immune Control KNIGHT, ROB UNIVERSITY OF CALIFORNIA, SAN DIEGO Mapping Host-Microbe-Metabolite Interactions in 3D to Find Diet-Derived Enhancers of Immunity LEE, JIN HYUNG STANFORD UNIVERSITY From Optogenetic Functional MRI to Mechanogenetic Functional Ultrasound PICCIOTTO, MARINA R YALE UNIVERSITY Acetylcholine Signaling Allows Cognitive Processes in the Brain to Regulate Physiological Responses to the Environment: The Example of Central Control of Opiate Tolerance PLOEGH, HIDDE L BOSTON CHILDREN'S HOSPITAL Imposing Order on the Family of Ubiquitin-Conjugating (E2) Enzymes Through Intracellular Perturbation with Nanobodies SCHEURING, SIMON WEILL MEDICAL COLL OF CORNELL UNIV Enabling Physical Stimuli in the Study of Structural Dynamics: The Sensory Ion Channels
2019 NIH Director's Pioneer Award (DP1) RFA-RM-18-007
PI Name Institution Name Title ANDERMANN, MARK L BETH ISRAEL DEACONESS MEDICAL CENTER Look Inward: Brainstem and Cortical Circuits for Boosting Interoceptive Attention EBERWINE, JAMES H UNIVERSITY OF PENNSYLVANIA The Secret Lives of RNA: The In Vivo 3D-Structural Logic of Single Neuron RNA Metabolism ELISSEEFF, JENNIFER H JOHNS HOPKINS UNIVERSITY Biomaterials-Directed Regenerative Immunotherapies GRECO, VALENTINA YALE UNIVERSITY Defining the Role of Mutational Burden in Sustaining Normal Homeostasis During Aging HERMAN, CHRISTOPHE BAYLOR COLLEGE OF MEDICINE A Synthetic Platform for Non-Antibiotic Eradication of Bacterial Infections HUR, SUN BOSTON CHILDREN'S HOSPITAL Resolving Functional Aggregates: A New Perspective on Innate Immune Control KNIGHT, ROB UNIVERSITY OF CALIFORNIA, SAN DIEGO Mapping Host-Microbe-Metabolite Interactions in 3D to Find Diet-Derived Enhancers of Immunity LEE, JIN HYUNG STANFORD UNIVERSITY From Optogenetic Functional MRI to Mechanogenetic Functional Ultrasound PICCIOTTO, MARINA R YALE UNIVERSITY Acetylcholine Signaling Allows Cognitive Processes in the Brain to Regulate Physiological Responses to the Environment: The Example of Central Control of Opiate Tolerance PLOEGH, HIDDE L BOSTON CHILDREN'S HOSPITAL Imposing Order on the Family of Ubiquitin-Conjugating (E2) Enzymes Through Intracellular Perturbation with Nanobodies SCHEURING, SIMON WEILL MEDICAL COLL OF CORNELL UNIV Enabling Physical Stimuli in the Study of Structural Dynamics: The Sensory Ion Channels
2018 NIH Director's Pioneer Award (DP1)
RFA-RM-17-005
PI Name Institution Name Title AYRES, JANELLE S SALK INSTITUTE FOR BIOLOGICAL STUDIES Host-Microbe Interactions: Harnessing Co-Evolution to Treat Disease COLON-RAMOS, DANIEL A YALE UNIVERSITY Powering the Brain: The Cell Biology of Neuroenergetics CURTIS, CHRISTINA N STANFORD UNIVERSITY Forecasting Tumor Evolution: Can the Past Reveal the Future? GRADINARU, VIVIANA CALIFORNIA INSTITUTE OF TECHNOLOGY Circuit-Specific Delivery of Large Cargo Across the Nervous Systems of Adult Mammals and Embryos Via Novel Engineered Systemic Vectors KIPNIS, JONATHAN UNIVERSITY OF VIRGINIA Neural Code of the Immune Responses KWON, HYUNGBAE MAX PLANCK FLORIDA CORPORATION Cracking the Neuromodulation Code at Single Cell Resolution MONJE-DEISSEROTH, MICHELLE STANFORD UNIVERSITY Glioma Circuitry: Bridging Systems Neuroscience and Cancer VICTORA, GABRIEL D ROCKEFELLER UNIVERSITY Quantifying Cell-Cell Interactions in the Immune System by Trans-Synaptic Labeling WAGERS, AMY JO HARVARD UNIVERSITY Uncovering Molecular Effectors of Mammalian Aging YIN, PENG HARVARD UNIVERSITY High-Throughput Single-Molecule Protein Identification Via Super-Resolution Imaging
2018 NIH Director's Pioneer Award (DP1) RFA-RM-17-005
PI Name Institution Name Title AYRES, JANELLE S SALK INSTITUTE FOR BIOLOGICAL STUDIES Host-Microbe Interactions: Harnessing Co-Evolution to Treat Disease COLON-RAMOS, DANIEL A YALE UNIVERSITY Powering the Brain: The Cell Biology of Neuroenergetics CURTIS, CHRISTINA N STANFORD UNIVERSITY Forecasting Tumor Evolution: Can the Past Reveal the Future? GRADINARU, VIVIANA CALIFORNIA INSTITUTE OF TECHNOLOGY Circuit-Specific Delivery of Large Cargo Across the Nervous Systems of Adult Mammals and Embryos Via Novel Engineered Systemic Vectors KIPNIS, JONATHAN UNIVERSITY OF VIRGINIA Neural Code of the Immune Responses KWON, HYUNGBAE MAX PLANCK FLORIDA CORPORATION Cracking the Neuromodulation Code at Single Cell Resolution MONJE-DEISSEROTH, MICHELLE STANFORD UNIVERSITY Glioma Circuitry: Bridging Systems Neuroscience and Cancer VICTORA, GABRIEL D ROCKEFELLER UNIVERSITY Quantifying Cell-Cell Interactions in the Immune System by Trans-Synaptic Labeling WAGERS, AMY JO HARVARD UNIVERSITY Uncovering Molecular Effectors of Mammalian Aging YIN, PENG HARVARD UNIVERSITY High-Throughput Single-Molecule Protein Identification Via Super-Resolution Imaging
2017 NIH Director's Pioneer Award (DP1)
RFA-RM-16-005
PI Name Institution Name Title DAI, HONGJIE STANFORD UNIVERSITY Human Infrared Vision at Molecular and Cellular Scale ETKIN, AMIT STANFORD UNIVERSITY A “Circuits-First” Platform for Personalized Neurostimulation Treatment FINE, HOWARD A WEILL MEDICAL COLL OF CORNELL UNIV Human Brain Cancer, Rather than Brain Cancer Cells, on a Plate LIEBER, CHARLES M HARVARD UNIVERSITY Syringe-Injectable Mesh Electronics for Seamless Integration with the Central Nervous System MACKLIS, JEFFREY D HARVARD UNIVERSITY Subcellular RNA-Proteome Mapping in Subtype- and Circuit-Specific Growth Cones: Development, Cell Biology, Disease, and Regeneration MARRAFFINI, LUCIANO A ROCKEFELLER UNIVERSITY Generation of Immunological Memory by CRISPR-Cas Systems SCHIER, ALEXANDER F HARVARD UNIVERSITY DNA-Mediated Recording of Cellular History SHIEKHATTAR, RAMIN UNIVERSITY OF MIAMI SCHOOL OF MEDICINE Enhancer RNA Therapy SINCLAIR, DAVID A HARVARD MEDICAL SCHOOL Uncovering the Human Secretome SONNENBURG, JUSTIN STANFORD UNIVERSITY Defining and Reconstructing the Human Ancestral Microbiome TYE, KAY MAXINE MASSACHUSETTS INSTITUTE OF TECHNOLOGY Neural Circuit Mechanisms of Social Homeostasis in Individuals and Supraorganismal Social Groups ZHANG, FENG BROAD INSTITUTE, INC. Exploration of Diverse Mobile Genetic Elements for Precision Genome Manipulation
2017 NIH Director's Pioneer Award (DP1) RFA-RM-16-005
PI Name Institution Name Title DAI, HONGJIE STANFORD UNIVERSITY Human Infrared Vision at Molecular and Cellular Scale ETKIN, AMIT STANFORD UNIVERSITY A “Circuits-First” Platform for Personalized Neurostimulation Treatment FINE, HOWARD A WEILL MEDICAL COLL OF CORNELL UNIV Human Brain Cancer, Rather than Brain Cancer Cells, on a Plate LIEBER, CHARLES M HARVARD UNIVERSITY Syringe-Injectable Mesh Electronics for Seamless Integration with the Central Nervous System MACKLIS, JEFFREY D HARVARD UNIVERSITY Subcellular RNA-Proteome Mapping in Subtype- and Circuit-Specific Growth Cones: Development, Cell Biology, Disease, and Regeneration MARRAFFINI, LUCIANO A ROCKEFELLER UNIVERSITY Generation of Immunological Memory by CRISPR-Cas Systems SCHIER, ALEXANDER F HARVARD UNIVERSITY DNA-Mediated Recording of Cellular History SHIEKHATTAR, RAMIN UNIVERSITY OF MIAMI SCHOOL OF MEDICINE Enhancer RNA Therapy SINCLAIR, DAVID A HARVARD MEDICAL SCHOOL Uncovering the Human Secretome SONNENBURG, JUSTIN STANFORD UNIVERSITY Defining and Reconstructing the Human Ancestral Microbiome TYE, KAY MAXINE MASSACHUSETTS INSTITUTE OF TECHNOLOGY Neural Circuit Mechanisms of Social Homeostasis in Individuals and Supraorganismal Social Groups ZHANG, FENG BROAD INSTITUTE, INC. Exploration of Diverse Mobile Genetic Elements for Precision Genome Manipulation
2016 NIH Director's Pioneer Award (DP1)
RFA-RM-13-006
PI Name Institution Name Title BALDWIN, KRISTIN KAY SCRIPPS RESEARCH INSTITUTE Defining a Transcriptional Periodic Table of the Human Brain Using Reprogramming BERNSTEIN, BRADLEY EVAN MASSACHUSETTS GENERAL HOSPITAL Epigenetic Plasticity in Tumor Initiation and Evolution FISCHBACH, MICHAEL ANDREW UNIVERSITY OF CALIFORNIA, SAN FRANCISCO A Complete Map of the Top 100 Molecules from the Gut Microbiome HASSON, URI PRINCETON UNIVERSITY Speaker-Listener Coupling: A Novel Neural Approach for Assessing Communication IZPISUA BELMONTE, JUAN CARLOS SALK INSTITUTE FOR BIOLOGICAL STUDIES Generation of Functional Human Organs and Tissues Using Interspecific Blastocyst Complementation KANWISHER, NANCY MASSACHUSETTS INSTITUTE OF TECHNOLOGY How Does the Functional Organization of the Human Brain Arise in Development? LIBERLES, STEPHEN DANIEL HARVARD MEDICAL SCHOOL Sensory Receptors of the Vagus Nerve MAYR, CHRISTINE SLOAN-KETTERING INST CAN RESEARCH 3'UTR-Mediated Protein-Protein Interactions Determine Protein Functions RABINOWITZ, JOSHUA D PRINCETON UNIVERSITY Metabolism in Action: Quantitative Fluxes in Mammals WANG, MENG CARLA BAYLOR COLLEGE OF MEDICINE Decode the Chemical Language that Orchestrates Cellular and Organismal Homeostasis WAY, SING SING CINCINNATI CHILDRENS HOSP MED CTR Immunological Identity Redefined by Genetically Foreign Microchimeric Cells YUN, SEOK-HYUN ANDY MASSACHUSETTS GENERAL HOSPITAL Massive Wavelength-Division Multiplexing and Imaging with Laser Particles
2016 NIH Director's Pioneer Award (DP1) RFA-RM-13-006
PI Name Institution Name Title BALDWIN, KRISTIN KAY SCRIPPS RESEARCH INSTITUTE Defining a Transcriptional Periodic Table of the Human Brain Using Reprogramming BERNSTEIN, BRADLEY EVAN MASSACHUSETTS GENERAL HOSPITAL Epigenetic Plasticity in Tumor Initiation and Evolution FISCHBACH, MICHAEL ANDREW UNIVERSITY OF CALIFORNIA, SAN FRANCISCO A Complete Map of the Top 100 Molecules from the Gut Microbiome HASSON, URI PRINCETON UNIVERSITY Speaker-Listener Coupling: A Novel Neural Approach for Assessing Communication IZPISUA BELMONTE, JUAN CARLOS SALK INSTITUTE FOR BIOLOGICAL STUDIES Generation of Functional Human Organs and Tissues Using Interspecific Blastocyst Complementation KANWISHER, NANCY MASSACHUSETTS INSTITUTE OF TECHNOLOGY How Does the Functional Organization of the Human Brain Arise in Development? LIBERLES, STEPHEN DANIEL HARVARD MEDICAL SCHOOL Sensory Receptors of the Vagus Nerve MAYR, CHRISTINE SLOAN-KETTERING INST CAN RESEARCH 3'UTR-Mediated Protein-Protein Interactions Determine Protein Functions RABINOWITZ, JOSHUA D PRINCETON UNIVERSITY Metabolism in Action: Quantitative Fluxes in Mammals WANG, MENG CARLA BAYLOR COLLEGE OF MEDICINE Decode the Chemical Language that Orchestrates Cellular and Organismal Homeostasis WAY, SING SING CINCINNATI CHILDRENS HOSP MED CTR Immunological Identity Redefined by Genetically Foreign Microchimeric Cells YUN, SEOK-HYUN ANDY MASSACHUSETTS GENERAL HOSPITAL Massive Wavelength-Division Multiplexing and Imaging with Laser Particles
2015 NIH Director's Pioneer Award (DP1)
RFA-RM-13-006
PI Name Institution Name Title BOSCO, GIOVANNI DARTMOUTH COLLEGE Trans-Generational Effects of Social Learning? COX, JEFFERY S UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Host-Directed Strategies to Create Synergistic Antibacterial Therapies DISNEY, MATTHEW D SCRIPPS FLORIDA Using a Disease-Affected Cell to Synthesize Its Own Drug GITAI, ZEMER PRINCETON UNIVERSITY Mechano-Microbiology: How Physical Forces Control Bacterial-Host Interactions HOWARD, JONATHON YALE UNIVERSITY Cell Biological Limitations Constrain Dendritic Branching Morphology and Neuronal Function MONTELL, CRAIG UNIVERSITY OF CALIFORNIA SANTA BARBARA Creation of a New Generation of Transgenic Mosquitoes to Control Infectious Disease MURPHY, COLEEN TARA PRINCETON UNIVERSITY Toward the Tissue-ome: A Map of the C. elegans Cell-specific Transcriptome RANDOLPH, GWENDALYN J WASHINGTON UNIVERSITY Integrating Cell & Lipoprotein Trafficking with Vascular Biology in Human IBD SCHIFF, STEVEN J PENNSYLVANIA STATE UNIVERSITY Control of the Neonatal Septisome and Hydrocephalus in Sub-Saharan Africa WU, HAO CHILDREN'S HOSPITAL CORPORATION SMOCs: Novel Signal Transduction Complexes as New Targets for Drug Discovery WYSS-CORAY, TONY PALO ALTO VETERANS INSTIT FOR RESEARCH A Bioorthogonal Approach to Study Mammalian Aging YASUDA, RYOHEI MAX PLANCK FLORIDA CORPORATION Deciphering Biochemical Networks in Single Dendritic Spines ZHONG, SHENG UNIVERSITY OF CALIFORNIA SAN DIEGO Mapping RNA interactomes by Sequencing
2015 NIH Director's Pioneer Award (DP1) RFA-RM-13-006
PI Name Institution Name Title BOSCO, GIOVANNI DARTMOUTH COLLEGE Trans-Generational Effects of Social Learning? COX, JEFFERY S UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Host-Directed Strategies to Create Synergistic Antibacterial Therapies DISNEY, MATTHEW D SCRIPPS FLORIDA Using a Disease-Affected Cell to Synthesize Its Own Drug GITAI, ZEMER PRINCETON UNIVERSITY Mechano-Microbiology: How Physical Forces Control Bacterial-Host Interactions HOWARD, JONATHON YALE UNIVERSITY Cell Biological Limitations Constrain Dendritic Branching Morphology and Neuronal Function MONTELL, CRAIG UNIVERSITY OF CALIFORNIA SANTA BARBARA Creation of a New Generation of Transgenic Mosquitoes to Control Infectious Disease MURPHY, COLEEN TARA PRINCETON UNIVERSITY Toward the Tissue-ome: A Map of the C. elegans Cell-specific Transcriptome RANDOLPH, GWENDALYN J WASHINGTON UNIVERSITY Integrating Cell & Lipoprotein Trafficking with Vascular Biology in Human IBD SCHIFF, STEVEN J PENNSYLVANIA STATE UNIVERSITY Control of the Neonatal Septisome and Hydrocephalus in Sub-Saharan Africa WU, HAO CHILDREN'S HOSPITAL CORPORATION SMOCs: Novel Signal Transduction Complexes as New Targets for Drug Discovery WYSS-CORAY, TONY PALO ALTO VETERANS INSTIT FOR RESEARCH A Bioorthogonal Approach to Study Mammalian Aging YASUDA, RYOHEI MAX PLANCK FLORIDA CORPORATION Deciphering Biochemical Networks in Single Dendritic Spines ZHONG, SHENG UNIVERSITY OF CALIFORNIA SAN DIEGO Mapping RNA interactomes by Sequencing
2014 NIH Director's Pioneer Award (DP1)
RFA-RM-13-006
PI Name Institution Name Title AMBATI, JAYAKRISHNA UNIVERSITY OF KENTUCKY Form and Function of Our Janus Faced Genome GU, CHENGHUA HARVARD MEDICAL SCHOOL New Tools for Understanding the Blood Brain Barrier LAURENCIN, CATO T, MD, PHD UNIVERSITY OF CONNECTICUT HEALTH CENTER Regenerative Engineering of Complex Musculoskeletal Tissues and Joints MONTELL, DENISE J UNIVERSITY OF CALIFORNIA SANTA BARBARA Anastasis, a New Mechanism Driving Cell Survival and Evolution NOVINA, CARL D DANA-FARBER CANCER INSTITUTE Engineering Epigenetic Therapy for Sickle Cell Disease PALMER, AMY E UNIVERSITY OF COLORADO Regulation of Cell Signaling by Transition Metal Dynamics PE'ER, DANA COLUMBIA UNIV NEW YORK MORNINGSIDE Single Cell Mapping of Developmental Trajectories Underlying Health and Disease RANDO, OLIVER J UNIV OF MASSACHUSETTS MED SCH WORCESTER tRNA Fragments as Transgenerational Information Carriers SPIEGELMAN, DONNA L HARVARD SCHOOL OF PUBLIC HEALTH Comprehensive Translational Science Analytics Tools for the Global Health Agenda WU, SEAN M STANFORD UNIVERSITY Enabling Technologies for Human-Machine Hybrid Tissues
2014 NIH Director's Pioneer Award (DP1) RFA-RM-13-006
PI Name Institution Name Title AMBATI, JAYAKRISHNA UNIVERSITY OF KENTUCKY Form and Function of Our Janus Faced Genome GU, CHENGHUA HARVARD MEDICAL SCHOOL New Tools for Understanding the Blood Brain Barrier LAURENCIN, CATO T, MD, PHD UNIVERSITY OF CONNECTICUT HEALTH CENTER Regenerative Engineering of Complex Musculoskeletal Tissues and Joints MONTELL, DENISE J UNIVERSITY OF CALIFORNIA SANTA BARBARA Anastasis, a New Mechanism Driving Cell Survival and Evolution NOVINA, CARL D DANA-FARBER CANCER INSTITUTE Engineering Epigenetic Therapy for Sickle Cell Disease PALMER, AMY E UNIVERSITY OF COLORADO Regulation of Cell Signaling by Transition Metal Dynamics PE'ER, DANA COLUMBIA UNIV NEW YORK MORNINGSIDE Single Cell Mapping of Developmental Trajectories Underlying Health and Disease RANDO, OLIVER J UNIV OF MASSACHUSETTS MED SCH WORCESTER tRNA Fragments as Transgenerational Information Carriers SPIEGELMAN, DONNA L HARVARD SCHOOL OF PUBLIC HEALTH Comprehensive Translational Science Analytics Tools for the Global Health Agenda WU, SEAN M STANFORD UNIVERSITY Enabling Technologies for Human-Machine Hybrid Tissues
2013 NIH Director's Pioneer Award (DP1)
RFA-RM-12-015
PI Name Institution Name Title ARNSTEN, AMY F T YALE UNIVERSITY Highly Evolved Brain Circuits in Primates: Molecular Vulnerabilities for Disease BOYDEN, EDWARD S MASSACHUSETTS INSTITUTE OF TECHNOLOGY Millisecond-Timescale Whole-Brain Neural Activity Mapping in Health and Disease GLADYSHEV, VADIM N BRIGHAM AND WOMEN'S HOSPITAL Mechanisms of Lifespan Control KHAKH, BALJIT UNIVERSITY OF CALIFORNIA LOS ANGELES Astrocyte Branchlet Dysfunction as an Early Step in Brain Disorders LIN, MICHAEL Z STANFORD UNIVERSITY Optogenetics for All: A General Method for Optical Control of Protein Activity SHENDURE, JAY ASHOK UNIVERSITY OF WASHINGTON Interpreting Genetic Variants of Uncertain Significance TRAYANOVA, NATALIA A JOHNS HOPKINS UNIVERSITY Virtual Electrophysiology Laboratory WANG, FAN DUKE UNIVERSITY Toward Causal Neuroscience: Capture and Manipulate Emergent Neuronal Ensembles WEINBERGER, LEOR S J. DAVID GLADSTONE INSTITUTES Evolvable Resistance-Proof Therapies XIE, XIAOLIANG SUNNEY HARVARD UNIVERSITY Probing Dynamics of the Human Genome by Single Cell Sequencing YUSTE, RAFAEL M COLUMBIA UNIV NEW YORK MORNINGSIDE Functional Connectomics of the Neocortical Microcircuit ZYLKA, MARK J UNIV OF NORTH CAROLINA CHAPEL HILL The Elongation Hypothesis of Autism
2013 NIH Director's Pioneer Award (DP1) RFA-RM-12-015
PI Name Institution Name Title ARNSTEN, AMY F T YALE UNIVERSITY Highly Evolved Brain Circuits in Primates: Molecular Vulnerabilities for Disease BOYDEN, EDWARD S MASSACHUSETTS INSTITUTE OF TECHNOLOGY Millisecond-Timescale Whole-Brain Neural Activity Mapping in Health and Disease GLADYSHEV, VADIM N BRIGHAM AND WOMEN'S HOSPITAL Mechanisms of Lifespan Control KHAKH, BALJIT UNIVERSITY OF CALIFORNIA LOS ANGELES Astrocyte Branchlet Dysfunction as an Early Step in Brain Disorders LIN, MICHAEL Z STANFORD UNIVERSITY Optogenetics for All: A General Method for Optical Control of Protein Activity SHENDURE, JAY ASHOK UNIVERSITY OF WASHINGTON Interpreting Genetic Variants of Uncertain Significance TRAYANOVA, NATALIA A JOHNS HOPKINS UNIVERSITY Virtual Electrophysiology Laboratory WANG, FAN DUKE UNIVERSITY Toward Causal Neuroscience: Capture and Manipulate Emergent Neuronal Ensembles WEINBERGER, LEOR S J. DAVID GLADSTONE INSTITUTES Evolvable Resistance-Proof Therapies XIE, XIAOLIANG SUNNEY HARVARD UNIVERSITY Probing Dynamics of the Human Genome by Single Cell Sequencing YUSTE, RAFAEL M COLUMBIA UNIV NEW YORK MORNINGSIDE Functional Connectomics of the Neocortical Microcircuit ZYLKA, MARK J UNIV OF NORTH CAROLINA CHAPEL HILL The Elongation Hypothesis of Autism
2012 NIH Director's Pioneer Award (DP1)
RFA-RM-11-004
PI Name Institution Name Title BRUNET, ANNE STANFORD UNIVERSITY Transgenerational Epigenetic Inheritance of Longevity MARCOTTE, EDWARD M UNIVERSITY OF TEXAS AUSTIN Next-Generation Proteomics: Massively Parallel Single-Molecule Protein Identification & Quantification PLOEGH, HIDDE L WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH A New Strategy to Disrupt Protein-Protein Interactions in Eukaryotic Cells SMOLKE, CHRISTINA D STANFORD UNIVERSITY Synthetic Biology Platforms for Natural Product Discovery and Biosynthesis TANG, YI UNIVERSITY OF CALIFORNIA LOS ANGELES Rediscovering Natural Chemical Diversity TSAO, DORIS YING CALIFORNIA INSTITUTE OF TECHNOLOGY Understanding the Circuit for Topological Object Tracking WANG, LIHONG WASHINGTON UNIVERSITY IN ST. LOUIS Photon Tunneling: Shedding New Light on Biomedicine WU, CHAO-TING HARVARD UNIVERSITY The Inheritance of Position: It's Not Just Who You Are, It's Where You Are YELLEN, GARY I HARVARD UNIVERSITY Single Cell Analysis of Metabolism Using Genetically-Encoded Fluorescent Sensors ZHANG, FENG BROAD INSTITUTE, INC. Probing Neuropsychiatric Diseases Using Targeted Epigenome and Genome Engineering
2012 NIH Director's Pioneer Award (DP1) RFA-RM-11-004
PI Name Institution Name Title BRUNET, ANNE STANFORD UNIVERSITY Transgenerational Epigenetic Inheritance of Longevity MARCOTTE, EDWARD M UNIVERSITY OF TEXAS AUSTIN Next-Generation Proteomics: Massively Parallel Single-Molecule Protein Identification & Quantification PLOEGH, HIDDE L WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH A New Strategy to Disrupt Protein-Protein Interactions in Eukaryotic Cells SMOLKE, CHRISTINA D STANFORD UNIVERSITY Synthetic Biology Platforms for Natural Product Discovery and Biosynthesis TANG, YI UNIVERSITY OF CALIFORNIA LOS ANGELES Rediscovering Natural Chemical Diversity TSAO, DORIS YING CALIFORNIA INSTITUTE OF TECHNOLOGY Understanding the Circuit for Topological Object Tracking WANG, LIHONG WASHINGTON UNIVERSITY IN ST. LOUIS Photon Tunneling: Shedding New Light on Biomedicine WU, CHAO-TING HARVARD UNIVERSITY The Inheritance of Position: It's Not Just Who You Are, It's Where You Are YELLEN, GARY I HARVARD UNIVERSITY Single Cell Analysis of Metabolism Using Genetically-Encoded Fluorescent Sensors ZHANG, FENG BROAD INSTITUTE, INC. Probing Neuropsychiatric Diseases Using Targeted Epigenome and Genome Engineering
2011 NIH Director's Pioneer Award (DP1)
RFA-RM-10-008
PI Name Institution Name Title BANERJEE, UTPAL UNIVERSITY OF CALIFORNIA LOS ANGELES Developmental Control of Metabolism BASS, BRENDA L UNIVERSITY OF UTAH Cellular Double-Stranded RNA as a Signal of Stress, Immunity, and Aging BENNETT, JEAN UNIVERSITY OF PENNSYLVANIA Broad Spectrum Molecular Therapy for Blinding Retina Disorders CLEMONS, WILLIAM M CALIFORNIA INSTITUTE OF TECHNOLOGY NIH Pioneer Award ENGERT, FLORIAN HARVARD UNIVERSITY Watching a Vertebrate Brain Learn and Behave in a Virtual Environment FEINBERG, ANDREW P JOHNS HOPKINS UNIVERSITY A General Stochastic Epigenetic Model for Evolution, Development, and Disease HILDRETH, JAMES E K MEHARRY MEDICAL COLLEGE Role of Natural Pseudotyping with Other Viruses in HIV Transmission PAN, TAO UNIVERSITY OF CHICAGO Mis-Translation as a New Mechanism of Stress Response in Biology RAMANATHAN, SHARAD HARVARD UNIVERSITY A Road Map to the Neocortex SCHNEIDER, DAVID S STANFORD UNIVERSITY Mapping the Road to Recovery - Does the Way We Get Better Differ from the Way We Get Sick? SIAPAS, ATHANASSIOS G CALIFORNIA INSTITUTE OF TECHNOLOGY Nanoprobe Arrays for Massively Parallel 3-D Recordings of Brain Activity TOLIAS, ANDREAS SAVAS BAYLOR COLLEGE OF MEDICINE Dissecting the Fabric of the Cerebral Cortex YANIK, MEHMET FATIH MASSACHUSETTS INSTITUTE OF TECHNOLOGY Generating Transplantable Neurons by In Vivo Combinatorial Screening of Transcription Regulator RNAs
2011 NIH Director's Pioneer Award (DP1) RFA-RM-10-008
PI Name Institution Name Title BANERJEE, UTPAL UNIVERSITY OF CALIFORNIA LOS ANGELES Developmental Control of Metabolism BASS, BRENDA L UNIVERSITY OF UTAH Cellular Double-Stranded RNA as a Signal of Stress, Immunity, and Aging BENNETT, JEAN UNIVERSITY OF PENNSYLVANIA Broad Spectrum Molecular Therapy for Blinding Retina Disorders CLEMONS, WILLIAM M CALIFORNIA INSTITUTE OF TECHNOLOGY NIH Pioneer Award ENGERT, FLORIAN HARVARD UNIVERSITY Watching a Vertebrate Brain Learn and Behave in a Virtual Environment FEINBERG, ANDREW P JOHNS HOPKINS UNIVERSITY A General Stochastic Epigenetic Model for Evolution, Development, and Disease HILDRETH, JAMES E K MEHARRY MEDICAL COLLEGE Role of Natural Pseudotyping with Other Viruses in HIV Transmission PAN, TAO UNIVERSITY OF CHICAGO Mis-Translation as a New Mechanism of Stress Response in Biology RAMANATHAN, SHARAD HARVARD UNIVERSITY A Road Map to the Neocortex SCHNEIDER, DAVID S STANFORD UNIVERSITY Mapping the Road to Recovery - Does the Way We Get Better Differ from the Way We Get Sick? SIAPAS, ATHANASSIOS G CALIFORNIA INSTITUTE OF TECHNOLOGY Nanoprobe Arrays for Massively Parallel 3-D Recordings of Brain Activity TOLIAS, ANDREAS SAVAS BAYLOR COLLEGE OF MEDICINE Dissecting the Fabric of the Cerebral Cortex YANIK, MEHMET FATIH MASSACHUSETTS INSTITUTE OF TECHNOLOGY Generating Transplantable Neurons by In Vivo Combinatorial Screening of Transcription Regulator RNAs
2010 NIH Director's Pioneer Award (DP1)
RFA-RM-09-010
PI Name Institution Name Title BARBAS, CARLOS F SCRIPPS RESEARCH INSTITUTE Chemically Programmed Immunity BJORKMAN, PAMELA J CALIFORNIA INSTITUTE OF TECHNOLOGY Thwarting HIV Evasion of Antibody Avidity with Novel Antibody Architectures DRAGOI, VALENTIN UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON Examining Population Coding Underlying Complex Behavior in Freely Moving Primates FESIK, STEPHEN W VANDERBILT UNIVERSITY MEDICAL CENTER Expanding the Druggable Genome HORVATH, TAMAS L YALE UNIVERSITY Hypothalamic AgRP Neurons Are Determinants of Healthy Lifespan and Higher Brain Functions JOUNG, J KEITH MASSACHUSETTS GENERAL HOSPITAL Advancing Stem Cell Technologies Using Engineered Zinc Finger Proteins KLEINFELD, DAVID UNIVERSITY OF CALIFORNIA SAN DIEGO Defining the Logic of Neurovascular Signaling in the Brain LIN, HAIFAN YALE UNIVERSITY Toward a Central Question in Epigenetics: A Major Epigenetic Programming Mechanism Guided by piRNAs LIU, JUN O JOHNS HOPKINS UNIVERSITY Generation and Proteome-Wide Screening of Hybrid Combinatorial Libraries MARICQ, ANDRES VILLU UNIVERSITY OF UTAH Simultaneous In Vivo Studies of Synapses, Neurons, and Learning and Memory NADEAU, JOSEPH H CASE WESTERN RESERVE UNIVERSITY Lamarck Redux: Transgenerational Genetic Effects on Phenotypes and Disease NICOLELIS, MIGUEL A L DUKE UNIVERSITY A Virtual Reality Simulator to Study VLSBA and Test Brain-Actuating Technologies RAMAKRISHNAN, LALITA UNIVERSITY OF WASHINGTON Linking the Behavior of Individual Host Cells to Their Transcriptional Signatures ROLE, LORNA W THE RESEARCH FOUNDATION OF SUNY Unveiling the Role and Taking Control of Cholinergic Tone in Circuits of Attention, Memory and Fear ROUKES, MICHAEL L CALIFORNIA INSTITUTE OF TECHNOLOGY Nanoscale Tools to Push Biomedical Frontiers SAMUDRALA, RAM UNIVERSITY OF WASHINGTON Novel Paradigms for Drug Discovery: Computational Multitarget Screening YANKNER, BRUCE A PRESIDENT AND FELLOWS OF HARVARD COLLEGE Modeling the Aging Epigenome
2010 NIH Director's Pioneer Award (DP1) RFA-RM-09-010
PI Name Institution Name Title BARBAS, CARLOS F SCRIPPS RESEARCH INSTITUTE Chemically Programmed Immunity BJORKMAN, PAMELA J CALIFORNIA INSTITUTE OF TECHNOLOGY Thwarting HIV Evasion of Antibody Avidity with Novel Antibody Architectures DRAGOI, VALENTIN UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON Examining Population Coding Underlying Complex Behavior in Freely Moving Primates FESIK, STEPHEN W VANDERBILT UNIVERSITY MEDICAL CENTER Expanding the Druggable Genome HORVATH, TAMAS L YALE UNIVERSITY Hypothalamic AgRP Neurons Are Determinants of Healthy Lifespan and Higher Brain Functions JOUNG, J KEITH MASSACHUSETTS GENERAL HOSPITAL Advancing Stem Cell Technologies Using Engineered Zinc Finger Proteins KLEINFELD, DAVID UNIVERSITY OF CALIFORNIA SAN DIEGO Defining the Logic of Neurovascular Signaling in the Brain LIN, HAIFAN YALE UNIVERSITY Toward a Central Question in Epigenetics: A Major Epigenetic Programming Mechanism Guided by piRNAs LIU, JUN O JOHNS HOPKINS UNIVERSITY Generation and Proteome-Wide Screening of Hybrid Combinatorial Libraries MARICQ, ANDRES VILLU UNIVERSITY OF UTAH Simultaneous In Vivo Studies of Synapses, Neurons, and Learning and Memory NADEAU, JOSEPH H CASE WESTERN RESERVE UNIVERSITY Lamarck Redux: Transgenerational Genetic Effects on Phenotypes and Disease NICOLELIS, MIGUEL A L DUKE UNIVERSITY A Virtual Reality Simulator to Study VLSBA and Test Brain-Actuating Technologies RAMAKRISHNAN, LALITA UNIVERSITY OF WASHINGTON Linking the Behavior of Individual Host Cells to Their Transcriptional Signatures ROLE, LORNA W THE RESEARCH FOUNDATION OF SUNY Unveiling the Role and Taking Control of Cholinergic Tone in Circuits of Attention, Memory and Fear ROUKES, MICHAEL L CALIFORNIA INSTITUTE OF TECHNOLOGY Nanoscale Tools to Push Biomedical Frontiers SAMUDRALA, RAM UNIVERSITY OF WASHINGTON Novel Paradigms for Drug Discovery: Computational Multitarget Screening YANKNER, BRUCE A PRESIDENT AND FELLOWS OF HARVARD COLLEGE Modeling the Aging Epigenome
2009 NIH Director's Pioneer Award (DP1)
RFA-RM-09-001
PI Name Institution Name Title BENJAMIN, IVOR J UNIVERSITY OF UTAH Protein Misfolding Diseases and Oxido-Reductive Pathways CHAWLA, AJAY STANFORD UNIVERSITY Immune Triggers of Tissue Regeneration CHEN, CHANG-ZHENG STANFORD UNIVERSITY The Role of Pre-miRNA Loop in Target Regulation by microRNA Genes CHEROUTRE, HILDE MC LA JOLLA INST FOR ALLERGY & IMMUNOLGY Uncovering the Missing Link that Determines Susceptibility to Autoimmunity COVERT, MARKUS W STANFORD UNIVERSITY A Gene-Complete Computational Model of Yeast DESIMONE, JOSEPH M UNIV OF NORTH CAROLINA CHAPEL HILL Delivery of Biological Therapeutics: Using Engineered Particles and Novel Delivery Methods to Address Unmet Needs EVANS, SYLVIA M UNIVERSITY OF CALIFORNIA SAN DIEGO Approaches to Cardiac Regeneration FETCHO, JOSEPH R CORNELL UNIVERSITY Global Changes in Synaptic Strength and Excitability During Sleep and Wakefulness HOLY, TIMOTHY WASHINGTON UNIVERSITY Watching Action Potentials in Intact Neuronal Circuits REYA, TANNISHTHA DUKE UNIVERSITY Imaging Self-Renewal and Transformation in Hematopoietic Stem Cells ROBINSON, GENE E UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN Johnny Bee Good: Bees as Models to Study the Hijacking of the Reward System ROSENBERG, SUSAN M BAYLOR COLLEGE OF MEDICINE Forward Genomics of Damage Control: An Undiscovered Class of Cancer Genes SAMSON, LEONA D MASSACHUSETTS INSTITUTE OF TECHNOLOGY Developing Novel Methods to Measure DNA Repair Capacity in Human Populations SHAH, NIRAO MAHESH UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Dissecting the Neural Control of Social Attachment SHENOY, KRISHNA V STANFORD UNIVERSITY Toward an Animal Model of Freely Moving Human TISHKOFF, SARAH ANNE UNIVERSITY OF PENNSYLVANIA African Odyssey: An Integrative Genomics Analysis of Complex Physiologic Traits TRAVIS, ALEXANDER J CORNELL UNIVERSITY Nanoscale Energy Production for Implantable Medical Devices ZHANG, JIN JOHNS HOPKINS UNIVERSITY Creating a Genetically Encodable Nano-Compass to Navigate in Molecular Networks
2009 NIH Director's Pioneer Award (DP1) RFA-RM-09-001
PI Name Institution Name Title BENJAMIN, IVOR J UNIVERSITY OF UTAH Protein Misfolding Diseases and Oxido-Reductive Pathways CHAWLA, AJAY STANFORD UNIVERSITY Immune Triggers of Tissue Regeneration CHEN, CHANG-ZHENG STANFORD UNIVERSITY The Role of Pre-miRNA Loop in Target Regulation by microRNA Genes CHEROUTRE, HILDE MC LA JOLLA INST FOR ALLERGY & IMMUNOLGY Uncovering the Missing Link that Determines Susceptibility to Autoimmunity COVERT, MARKUS W STANFORD UNIVERSITY A Gene-Complete Computational Model of Yeast DESIMONE, JOSEPH M UNIV OF NORTH CAROLINA CHAPEL HILL Delivery of Biological Therapeutics: Using Engineered Particles and Novel Delivery Methods to Address Unmet Needs EVANS, SYLVIA M UNIVERSITY OF CALIFORNIA SAN DIEGO Approaches to Cardiac Regeneration FETCHO, JOSEPH R CORNELL UNIVERSITY Global Changes in Synaptic Strength and Excitability During Sleep and Wakefulness HOLY, TIMOTHY WASHINGTON UNIVERSITY Watching Action Potentials in Intact Neuronal Circuits REYA, TANNISHTHA DUKE UNIVERSITY Imaging Self-Renewal and Transformation in Hematopoietic Stem Cells ROBINSON, GENE E UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN Johnny Bee Good: Bees as Models to Study the Hijacking of the Reward System ROSENBERG, SUSAN M BAYLOR COLLEGE OF MEDICINE Forward Genomics of Damage Control: An Undiscovered Class of Cancer Genes SAMSON, LEONA D MASSACHUSETTS INSTITUTE OF TECHNOLOGY Developing Novel Methods to Measure DNA Repair Capacity in Human Populations SHAH, NIRAO MAHESH UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Dissecting the Neural Control of Social Attachment SHENOY, KRISHNA V STANFORD UNIVERSITY Toward an Animal Model of Freely Moving Human TISHKOFF, SARAH ANNE UNIVERSITY OF PENNSYLVANIA African Odyssey: An Integrative Genomics Analysis of Complex Physiologic Traits TRAVIS, ALEXANDER J CORNELL UNIVERSITY Nanoscale Energy Production for Implantable Medical Devices ZHANG, JIN JOHNS HOPKINS UNIVERSITY Creating a Genetically Encodable Nano-Compass to Navigate in Molecular Networks
2008 NIH Director's Pioneer Award (DP1)
RFA-RM-08-013
PI Name Institution Name Title CHEN, JAMES K STANFORD UNIVERSITY Chemical Embryology: Technologies for Manipulating and Visualizing Development DOLMETSCH, RICARDO E STANFORD UNIVERSITY Using Induced Pluripotent Stem Cells to Identify Cellular Phenotypes of Autism EBERWINE, JAMES H UNIVERSITY OF PENNSYLVANIA Cellular Logic of Phenotype EPSTEIN, JOSHUA M BROOKINGS INSTITUTION Behavioral Epidemiology: Applications of Agent-Based Modeling to Infectious Disease HAY, BRUCE A CALIFORNIA INSTITUTE OF TECHNOLOGY Engineering the Genetics of Wild Mosquito Populations to Fight Infectious Disease HOCHSCHILD, ANN HARVARD MEDICAL SCHOOL A New Genetic Approach for Studying Prions and Other Pathogenic Protein Aggregate LIEBER, CHARLES M HARVARD UNIVERSITY Nanowire Nanoelectronic/Cell Assemblies as Hybrid Functional Biomaterials LONDON, BARRY UNIVERSITY OF PITTSBURGH AT PITTSBURGH In-Vivo Electrophysiology ImagingMANIATIS, THOMAS P HARVARD UNIVERSITY Use of Induced Pluripotent Stem Cells to Study Mechanisms of Familial and Sporadic ALS ODOM, TERI WANG NORTHWESTERN UNIVERSITY Reconstructing Sub-cellular Structure Using Plasmonic Metamaterials PARK, HONGKUN HARVARD UNIVERSITY Nano- and Microelectronic Tools for Interrogating Neuronal Circuits and Networks REGEV, AVIV MASSACHUSETTS INSTITUTE OF TECHNOLOGY | BROAD INSTITUTE, INC. The Temporal Reconfiguration of Regulatory Networks: From Yeast to Cancer SAMUEL, ARAVINTHAN D HARVARD UNIVERSITY Biophysical Approaches to Complex Navigational Behaviors in Larval Drosophila melanogaster TAVAZOIE, SAEED F PRINCETON UNIVERSITY Towards a Cognitive Framework for Understanding Cellular Behavior TING, ALICE Y MASSACHUSETTS INSTITUTE OF TECHNOLOGY Enabling the Study of Endogenous Proteins in Live Cells VAN OUDENAARDEN, ALEXANDER MASSACHUSETTS INSTITUTE OF TECHNOLOGY Stochastic Gene Expression in Differentiation and Development
2008 NIH Director's Pioneer Award (DP1) RFA-RM-08-013
PI Name Institution Name Title CHEN, JAMES K STANFORD UNIVERSITY Chemical Embryology: Technologies for Manipulating and Visualizing Development DOLMETSCH, RICARDO E STANFORD UNIVERSITY Using Induced Pluripotent Stem Cells to Identify Cellular Phenotypes of Autism EBERWINE, JAMES H UNIVERSITY OF PENNSYLVANIA Cellular Logic of Phenotype EPSTEIN, JOSHUA M BROOKINGS INSTITUTION Behavioral Epidemiology: Applications of Agent-Based Modeling to Infectious Disease HAY, BRUCE A CALIFORNIA INSTITUTE OF TECHNOLOGY Engineering the Genetics of Wild Mosquito Populations to Fight Infectious Disease HOCHSCHILD, ANN HARVARD MEDICAL SCHOOL A New Genetic Approach for Studying Prions and Other Pathogenic Protein Aggregate LIEBER, CHARLES M HARVARD UNIVERSITY Nanowire Nanoelectronic/Cell Assemblies as Hybrid Functional Biomaterials LONDON, BARRY UNIVERSITY OF PITTSBURGH AT PITTSBURGH In-Vivo Electrophysiology ImagingMANIATIS, THOMAS P HARVARD UNIVERSITY Use of Induced Pluripotent Stem Cells to Study Mechanisms of Familial and Sporadic ALS ODOM, TERI WANG NORTHWESTERN UNIVERSITY Reconstructing Sub-cellular Structure Using Plasmonic Metamaterials PARK, HONGKUN HARVARD UNIVERSITY Nano- and Microelectronic Tools for Interrogating Neuronal Circuits and Networks REGEV, AVIV MASSACHUSETTS INSTITUTE OF TECHNOLOGY | BROAD INSTITUTE, INC. The Temporal Reconfiguration of Regulatory Networks: From Yeast to Cancer SAMUEL, ARAVINTHAN D HARVARD UNIVERSITY Biophysical Approaches to Complex Navigational Behaviors in Larval Drosophila melanogaster TAVAZOIE, SAEED F PRINCETON UNIVERSITY Towards a Cognitive Framework for Understanding Cellular Behavior TING, ALICE Y MASSACHUSETTS INSTITUTE OF TECHNOLOGY Enabling the Study of Endogenous Proteins in Live Cells VAN OUDENAARDEN, ALEXANDER MASSACHUSETTS INSTITUTE OF TECHNOLOGY Stochastic Gene Expression in Differentiation and Development
2007 NIH Director's Pioneer Award (DP1)
RFA-RM-07-005
PI Name Institution Name Title BARRETT, LISA FELDMAN BOSTON COLLEGE Emotions Are Emergent Events Constrained by Affective and Conceptual Processes BEARMAN, PETER SHAWN COLUMBIA UNIV NEW YORK MORNINGSIDE Social Determinants of the Autism Epidemic BROWN, EMERY N MASSACHUSETTS GENERAL HOSPITAL A Systems Neuroscience Approach for the Study of General Anesthesia CLANDININ, THOMAS ROBERT STANFORD UNIVERSITY Dissecting the Functional Anatomy of the Visual System: A New Way Forward COLLINS, JAMES J BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) A Network Biology Approach to Antibiotic Action and Bacterial Defense Mechanisms GARDEL, MARGARET LISE UNIVERSITY OF CHICAGO 2007 NIH Directors Pioneer Award Program (DP1) HENSCH, TAKAO K CHILDREN'S HOSPITAL CORPORATION Dissecting Non-Coding RNA Function in Critical Period Brain Development/ Disorder HORWITZ, MARSHALL S UNIVERSITY OF WASHINGTON NIH Directors Pioneer Award ISMAGILOV, RUSTEM F UNIVERSITY OF CHICAGO 2007 NIH Directors Pioneer Award Program (DP1) JENSEN, FRANCES E CHILDREN'S HOSPITAL CORPORATION Understanding the Cognitive Impact of Early Life Epilepsy SCHNITZER, MARK J STANFORD UNIVERSITY Massively Parallel Brain Imaging TURRIGIANO, GINA G BRANDEIS UNIVERSITY Probing the Structure of the Synapse Using Superresolution Light Microscopy
2007 NIH Director's Pioneer Award (DP1) RFA-RM-07-005
PI Name Institution Name Title BARRETT, LISA FELDMAN BOSTON COLLEGE Emotions Are Emergent Events Constrained by Affective and Conceptual Processes BEARMAN, PETER SHAWN COLUMBIA UNIV NEW YORK MORNINGSIDE Social Determinants of the Autism Epidemic BROWN, EMERY N MASSACHUSETTS GENERAL HOSPITAL A Systems Neuroscience Approach for the Study of General Anesthesia CLANDININ, THOMAS ROBERT STANFORD UNIVERSITY Dissecting the Functional Anatomy of the Visual System: A New Way Forward COLLINS, JAMES J BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) A Network Biology Approach to Antibiotic Action and Bacterial Defense Mechanisms GARDEL, MARGARET LISE UNIVERSITY OF CHICAGO 2007 NIH Directors Pioneer Award Program (DP1) HENSCH, TAKAO K CHILDREN'S HOSPITAL CORPORATION Dissecting Non-Coding RNA Function in Critical Period Brain Development/ Disorder HORWITZ, MARSHALL S UNIVERSITY OF WASHINGTON NIH Directors Pioneer Award ISMAGILOV, RUSTEM F UNIVERSITY OF CHICAGO 2007 NIH Directors Pioneer Award Program (DP1) JENSEN, FRANCES E CHILDREN'S HOSPITAL CORPORATION Understanding the Cognitive Impact of Early Life Epilepsy SCHNITZER, MARK J STANFORD UNIVERSITY Massively Parallel Brain Imaging TURRIGIANO, GINA G BRANDEIS UNIVERSITY Probing the Structure of the Synapse Using Superresolution Light Microscopy
2006 NIH Director's Pioneer Award (DP1)
RFA-RM-06-005
PI Name Institution Name Title BOAHEN, KWABENA STANFORD UNIVERSITY Neurogrid: Emulating a Million Neurons in the Cortex CHAKRABORTY, ARUP K MASSACHUSETTS INSTITUTE OF TECHNOLOGY Developing the Principles Governing T Lymphocyte-Mediated Autoimmunity Using an Approach at an Intersection of the Physical and Life Sciences GIERASCH, LILA M UNIVERSITY OF MASSACHUSETTS AMHERST NIH Director's Pioneer Award Application HEALD, REBECCA W UNIVERSITY OF CALIFORNIA BERKELEY NIH Director's Pioneer Award Application KIRKEGAARD, KARLA A STANFORD UNIVERSITY Dominant Drug Targets in RNA Viruses KODADEK, THOMAS UNIVERSITY OF TEXAS SW MED CTR/DALLAS Novel Chemistry to Monitor and Manipulate the Immune System LEE, CHENG C UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON Reversible Suspended Animation of Non-hibernating Mammals NUDLER, EVGENY NEW YORK UNIVERSITY SCHOOL OF MEDICINE New Approaches to Fight Infection PIELAK, GARY J UNIVERSITY OF NORTH CAROLINA CHAPEL HILL In-Cell NMR of Disease-Related Proteins RELMAN, DAVID A STANFORD UNIVERSITY NIH Director's Pioneer Award Application SEGAL, ROSALIND A DANA-FARBER CANCER INSTITUTE An Extended View of Self: Human Indigenous Microbial Communities in Health and Disease SHERLEY, JAMES L MASSACHUSETTS INSTITUTE OF TECHNOLOGY Pioneering Human Adult Stem Cell Discovery and Cellular Medicine XIA, YOUNAN UNIVERSITY OF WASHINGTON Put Nanostructures to Work for Reading and Controlling Cell Behavior
2006 NIH Director's Pioneer Award (DP1) RFA-RM-06-005
PI Name Institution Name Title BOAHEN, KWABENA STANFORD UNIVERSITY Neurogrid: Emulating a Million Neurons in the Cortex CHAKRABORTY, ARUP K MASSACHUSETTS INSTITUTE OF TECHNOLOGY Developing the Principles Governing T Lymphocyte-Mediated Autoimmunity Using an Approach at an Intersection of the Physical and Life Sciences GIERASCH, LILA M UNIVERSITY OF MASSACHUSETTS AMHERST NIH Director's Pioneer Award Application HEALD, REBECCA W UNIVERSITY OF CALIFORNIA BERKELEY NIH Director's Pioneer Award Application KIRKEGAARD, KARLA A STANFORD UNIVERSITY Dominant Drug Targets in RNA Viruses KODADEK, THOMAS UNIVERSITY OF TEXAS SW MED CTR/DALLAS Novel Chemistry to Monitor and Manipulate the Immune System LEE, CHENG C UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON Reversible Suspended Animation of Non-hibernating Mammals NUDLER, EVGENY NEW YORK UNIVERSITY SCHOOL OF MEDICINE New Approaches to Fight Infection PIELAK, GARY J UNIVERSITY OF NORTH CAROLINA CHAPEL HILL In-Cell NMR of Disease-Related Proteins RELMAN, DAVID A STANFORD UNIVERSITY NIH Director's Pioneer Award Application SEGAL, ROSALIND A DANA-FARBER CANCER INSTITUTE An Extended View of Self: Human Indigenous Microbial Communities in Health and Disease SHERLEY, JAMES L MASSACHUSETTS INSTITUTE OF TECHNOLOGY Pioneering Human Adult Stem Cell Discovery and Cellular Medicine XIA, YOUNAN UNIVERSITY OF WASHINGTON Put Nanostructures to Work for Reading and Controlling Cell Behavior
2005 NIH Director's Pioneer Award (DP1)
NOT-OD-05-021
PI Name Institution Name Title CHANDLER, VICKI L UNIVERSITY OF ARIZONA NIH Director's Pioneer Award CLINE, HOLLIS T COLD SPRING HARBOR LABORATORY NIH Director's Pioneer Award COSMIDES, LEDA UNIVERSITY OF CALIFORNIA SANTA BARBARA NIH Director's Pioneer Award DE LANGE, TITIA ROCKEFELLER UNIVERSITY NIH Director's Pioneer Award DEISSEROTH, KARL A STANFORD UNIVERSITY NIH Director's Pioneer Award HARBURY, PEHR A STANFORD UNIVERSITY SCHOOL OF MEDICINE NIH Director's Pioneer Award JARVIS, ERICH D DUKE UNIVERSITY MEDICAL CENTER NIH Director's Pioneer Award RANDO, THOMAS A STANFORD UNIVERSITY SCHOOL OF MEDICINE NIH Director's Pioneer Award SMITH, DEREK J UNIVERSITY OF CAMBRIDGE NIH Director's Pioneer Award TONONI, GIULIO UNIVERSITY OF WISCONSIN - MADISON MEDICAL SCHOOL NIH Director's Pioneer Award WATERMAN-STORER, CLARE M SCRIPPS RESEARCH INSTITUTE NIH Director's Pioneer Award WOLFE, NATHAN JOHNS HOPKINS UNIVERSITY NIH Director's Pioneer Award YUAN, JUNYING HARVARD MEDICAL SCHOOL NIH Director's Pioneer Award
2005 NIH Director's Pioneer Award (DP1) NOT-OD-05-021
PI Name Institution Name Title CHANDLER, VICKI L UNIVERSITY OF ARIZONA NIH Director's Pioneer Award CLINE, HOLLIS T COLD SPRING HARBOR LABORATORY NIH Director's Pioneer Award COSMIDES, LEDA UNIVERSITY OF CALIFORNIA SANTA BARBARA NIH Director's Pioneer Award DE LANGE, TITIA ROCKEFELLER UNIVERSITY NIH Director's Pioneer Award DEISSEROTH, KARL A STANFORD UNIVERSITY NIH Director's Pioneer Award HARBURY, PEHR A STANFORD UNIVERSITY SCHOOL OF MEDICINE NIH Director's Pioneer Award JARVIS, ERICH D DUKE UNIVERSITY MEDICAL CENTER NIH Director's Pioneer Award RANDO, THOMAS A STANFORD UNIVERSITY SCHOOL OF MEDICINE NIH Director's Pioneer Award SMITH, DEREK J UNIVERSITY OF CAMBRIDGE NIH Director's Pioneer Award TONONI, GIULIO UNIVERSITY OF WISCONSIN - MADISON MEDICAL SCHOOL NIH Director's Pioneer Award WATERMAN-STORER, CLARE M SCRIPPS RESEARCH INSTITUTE NIH Director's Pioneer Award WOLFE, NATHAN JOHNS HOPKINS UNIVERSITY NIH Director's Pioneer Award YUAN, JUNYING HARVARD MEDICAL SCHOOL NIH Director's Pioneer Award
2004 NIH Director's Pioneer Award (DP1)
RFA-RM-04-500
2004 NIH Director's Pioneer Award (DP1) RFA-RM-04-500
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